408 research outputs found

    Hierarchical clustering and tree stability

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    Hierarchical clustering via neighbor joining, widely used in biology, can be quite sensitive to the addition or deletion of single taxa. In an earlier study it was found that neighbor joining trees on random data were commonly quite unstable in the sense that large re-arrangements of the tree occurred when the tree was reconstructed after the deletion of a single data point. In this study, we use an evolutionary algorithm to evolve extremely stable and unstable data sets for a standard neighbor-joining algorithm and then check the stability using a novel type of clustering called bubble clustering. Bubble clustering is an instance of associator clustering. The stability measure used is based on the size of the subtree containing each pair of taxa, a quantity that provides an objective measure of a given trees hypothesis about the relatedness of taxa. It is shown experimentally that even in data sets evolved to be stable for a standard neighbor joining algorithm, bubble clustering is a significantly more stable algorithm

    Location Independent Working In Academia: Enabling employees or supporting managerial control?

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    In this article, we consider the extent to which the practice of location independent working (LIW) enables academic employees to make choices and have agency in their life-work balance, and the extent to which it may support (or potentially be used as a form of resistance to) increased managerial control. Set within the context of an increasingly performance-led, managerialist public sector landscape, the impact and implications of these working practices are examined through the lens of labour process theory. Drawing on findings from an ongoing in-depth ethnographic study set in a post-1992 university business school in central England, we suggest that the practice of LIW is being used both to enable employees and to support managerial control

    Evaluation of an Innovative Student-Led Work Disability Prevention Program

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    A university-based, role-emerging fieldwork placement for occupational therapy students has been developed to provide work disability prevention services for university managers and workers. Over five years, 24 students have provided holistic interventions across 18 departments. The purpose of this project was to formally evaluate the perceptions of the program and the impact of services on managers and workers and to examine the experience of participating students. A utilization-focused evaluation approach was used as the guiding framework for this project. Methods included a retrospective review of reports and educational materials, a manager and worker survey, and a review of results from an existing student survey. The retrospective review of reports and educational materials demonstrated that students utilized a comprehensive and holistic lens that considered the interaction between the person, environment, and occupation. Workers and managers reported they were satisfied and found that services were beneficial. The majority reported changing their work setup or work habits after receiving student services to prevent workplace disability. Students reported overwhelmingly positive responses about the placement, with 96% (n=23) of students agreeing that they had an excellent experience and 100% (n=24) of students agreeing they were able to use their acquired knowledge. This paper describes the formal evaluation process and the outcomes of the project. Findings support the benefits of a partnership with human resources and occupational therapy in developing a role-emerging placement that benefits students, workers, and the organization and promotes the value of occupational therapy in workplace disability prevention and health promotion

    Does Cooperative Learning Increase Participation in the Classroom?

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    This Capstone Project analyzes literature and research to prove whether or not cooperative learning increases student participation in the classroom. The literature supports that cooperative learning does increase participation within the classroom. The literature also supports positive social interaction, academic achievement and instructional effectiveness. Research was then conducted in a 6th grade social studies classroom to determine whether or not the use of various classroom strategies were effective in increasing participation. This study found that each cooperative learning strategy has its own purpose, depending on the lesson it is used with. Overall, cooperative learning is an effective teaching strategy. Students need to be exposed to a variety of ways to learn, and these strategies allow teachers to meet the needs of all students

    Final Report: Tree Climbing Robot

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    The motivation for this project was to minimize the injury and fatality rate of loggers across the world due to inclement weather, structurally unsound tress, and bulky equipment used to trim trees by designing a robot with the ability to climb trees and trim branches. Due to budget and time constraints, the scope of the project was limited to autonomously climbing and descending a tree trunk while avoiding branches; however, the possibility of future modifications was considered in the design. Design criteria included maneuverability, reversibility, simplicity, vertical speed, the ability to climb a tree of fixed diameter, and the ability to carry extra weight. The final design was a “caterpillar”-style robot, and the major modular subsystems of the design included clamping, extension, rotation, and branch detection. The final design, construction, and testing of each of these subsystems is discussed, as well as the testing of the system as a whole. Ultimately, the design was deemed a success, with the exception of the failure of the rotation system

    Staff perceptions of the effectiveness of managerial communication during the COVID-19 pandemic: A cross-sectional study

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    Aims: This work aims to explore staff perceptions of (1) the effectiveness of organizational communication during the COVID-19 pandemic and (2) the impact of organizational communication on staff well-being and ability to progress their work and patient care. Background: Effective coordination and communication are essential in a pandemic management response. However, the effectiveness of communication strategies used during the COVID-19 pandemic is not well understood. Design: An exploratory cross-sectional research design was used. A 33-item survey tool was created for the study. Methods: The study was conducted at a tertiary teaching hospital in Western Australia. Convenience sampling was used to recruit participants from nursing, medical, allied health services, administrative and clerical, and personal support services (N = 325). Data were collected between December 2020 and May 2021. Results: Overall, all occupational groups found working during the COVID-19 pandemic stressful, and all groups wanted accessible and accurate communication from management and new policies, procedures, and protocols for future outbreaks. Conclusions: The use of occupational group-relevant strategies and COVID-19 protocols, as well as the on-going use of email, face-to-face meetings with debrief sessions, are needed to improve communication and support staff to fulfil their roles

    Flexural fatigue behavior of rocking bioreactor films

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    The fields of biopharmaceutical processing and cell therapy are adopting single-use, closed systems throughout their workflows to enhance sterility, minimize waste wash effluent and enable manufacturing flexibility compared to traditional stainless steel bioreactors. One of the key single-use technologies in use is the rocking bioreactor, comprising a polymer film bag (outfitted with ports and sensors) mounted to a tray capable of mixing the contents of the bag and a control system (controlling temperature, agitation, and potentially media perfusion). One of the challenges encountered in rocking bioreactor bags is the fact that upon inflation/filling with media, the originally flat bioreactor bags often develop folds and dimples due to their inflated geometry. These deformations tend to be inconsequential at small volumes and low agitation rates/times, but can lead to flex fatigue failures such as whitening, delamination and through-cracking under more extreme conditions. In practice, these failures are dependent on a number of factors including bag material and volume, mounting geometry, rocking angle and rate, and the duration of culture, making a systematic study of the material properties controlling this behavior difficult and time-consuming. Several flex fatigue testing systems exist in the literature, including Gelbo and Sonntag-Universal, but none of these effectively model the unique geometry and stresses of the rocking bioreactor geometry. To this end, we have developed accelerated test methods to analyze the flexural fatigue behavior of multilayer rocking bioreactor films. These methods enable quality control testing of film lots, and have the potential to compare different film compositions with a rapid and reproducible test, thereby facilitating development of new films. Our test method models the local geometry surrounding the fold/dimple in a rocking bioreactor in a small sample of film, and cycles the sample to accelerate flexural fatigue at the dimple site. Initial results indicate the ability to accelerate film failure from tens of days on a rocking bioreactor platform (using a full bioreactor bag) to tens of hours using less than ten square inches of film. We will discuss the effects of various experimental parameters on film failure, optimization of test procedures and correlation with rocking bioreactor testing in the field

    How do people with diabetes describe their experiences in primary care? Evidence from 85,760 patients with self-reported diabetes from the English General Practice Patient Survey.

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    OBJECTIVE: Developing primary care is an important current health policy goal in the U.S. and England. Information on patients' experience can help to improve the care of people with diabetes. We describe the experiences of people with diabetes in primary care and examine how these experiences vary with increasing comorbidity. RESEARCH DESIGN AND METHODS: Using data from 906,578 responders to the 2012 General Practice Patient Survey (England), including 85,760 with self-reported diabetes, we used logistic regressions controlling for age, sex, ethnicity, and socioeconomic status to analyze patient experience using seven items covering three domains of primary care: access, continuity, and communication. RESULTS: People with diabetes were significantly more likely to report better experience on six out of seven primary care items than people without diabetes after adjusting for age, sex, ethnicity, and socioeconomic status (adjusted differences 0.88-3.20%; odds ratios [ORs] 1.07-1.18; P < 0.001). Those with diabetes and additional comorbid long-term conditions were more likely to report worse experiences, particularly for access to primary care appointments (patients with diabetes alone compared with patients without diabetes: OR 1.22 [95% CI 1.17-1.28] and patients with diabetes plus three or more conditions compared with patients without diabetes: OR 0.87 [95% CI 0.83-0.91]). CONCLUSIONS: People with diabetes in England report primary care experiences that are at least as good as those without diabetes for most domains of care. However, improvements in primary care are needed for diabetes patients with comorbid long-term conditions, including better access to appointments and improved communication.Diabetes UKThis is the author accepted manuscript. The final version is available from the American Diabetes Association via http://dx.doi.org/10.2337/dc14-109

    Association between Prenatal Care and Gestational Weight Gain: Cross-Sectional Study in a Low-Income Area of Rio de Janeiro

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    Objetivo: Verificar a associação entre a adequação da assistência pré-natal e o ganho de peso gestacional (GPG) em puérperas brasileiras de baixa renda. Métodos: Estudo transversal no município de Mesquita-RJ, incluindo 281 mulheres no pós-parto imediato. O GPG foi classificado como adequado, insuficiente e excessivo de acordo com as recomendações do Institute of Medicine (IOM). O número de consultas do pré-natal foi categorizado (1: nenhuma consulta; 2: 1-3 consultas; 3: 4-6 consultas; 4: 7 ou mais consultas) e o início do pré-natal, segundo as semanas gestacionais (SG), foi utilizado como variável contínua. A assistência pré-natal (AP) avaliou as duas dimensões agrupadas do Índice de Kotelchuck: adequado (adequado + mais adequado) ou inadequado (intermediário e inadequado). Modelos de regressão logística multinomial foram utilizados para estimar as associações entre assistência pré-natal inadequada e GPG. Resultados: AP foi iniciada em média com 12,6 (± 6,9) SG; 8,2% das mulheres (n = 23) fizeram ≤ 4 consultas de pré-natal e 38,4% (n = 108) foram classificadas com AP inadequada. Em média, o GPG foi de 12,9 kg (± 6,2) e 36,5%, 31,0% e 32,5% das mulheres apresentaram GPG adequado, insuficiente e excessivo, respectivamente. Após o ajuste, a inadequação da AP (OR = 2,01; IC 95% = 1,03-3,90) foi associada a uma maior probabilidade de GPG abaixo das recomendações do IOM. Conclusão: Observou-se uma associação significativa entre a inadequação da assistência pré-natal e o GPG insuficiente, o que reforça a relevância da adequada AP para monitorar o adequado GPG e intervir precocemente na gestação
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