SYNTHESIS AND BIOLOGICAL ACTIVITIES OF SOME INDOLE ANALOGUES CONTAINING TRIAZOLE-5-THIOL AND THIAZOLOTRIAZOLE SYSTEMS

Objective: The present study aims at the synthesis and evaluation of antimicrobial and antioxidant activities of indole analogues incorporated with triazole and thiazolotriazole moieties. Methods: The newly synthesized compounds were screened for their antimicrobial activity by cup-plate method. Antioxidant activity by three different methods viz.,1,1-diphenyl-2-picryl hydrazil (DPPH) radical scavenging activity (RSA), ferric ion (Fe3+) reducing power (FRAP) and ferrous (Fe2+) ion metal chelating activity were appraised by calorimetric method using UV-Visible spectrophotometer. Results: The structures of all the newly synthesized compounds have been established on the basis of their IR, 1HNMR, [13]CNMR and mass spectral studies and elemental analysis. Compound 4a showed good radical scavenging activity (RSA), 4b showed good ferric ion (Fe3+) reducing antioxidant power (FRAP) and compounds 3c and 4a exhibited good ferrous ion metal chelating activity. Whereas compound 3b showed good antibacterial activity against P. aeruginosa, 4a against S. aureus and 4c against E. coli. While for the antifungal activity compound 3a was good against A. oryzae, 3c against A. nizer and 4a against A. flavus. Conclusion: Antimicrobial and antioxidant activity results of the newly synthesized compounds indicate that some of the compounds showed better antimicrobial and antioxidant activities with reference to the standard drugs

Synthesis, antimicrobial and antioxidant activities of some indole analogues containing naphthyridine and pyrimidonaphthyridine systems

1593-1606  2-Amino-4-(2'-methoxynapthalen-6'-yl)-6-(4-subtituted phenyl)-pyridin-3-carbonitriles 2a-c have been prepared by cyclocondensation of substituted chalcones 1a-c with malanonitrile in the presence of ammonium acetate. The compounds 2a-c on cyclocondensation with (5'-substituted 2'-phenyl-1<i style="mso-bidi-font-style: normal">H-indol-3'-yl)-acrylonitriles 3a-c afford the key intermediates 4-amino-5-(2'-methoxynaphthalen-6'-yl)-7-aryl-2-(5'-substituted 2'-phenyl-1H-indol-3'-yl)-1,8-naphthyridin-5-carbonitriles 4a-i. Compounds <b style="mso-bidi-font-weight: normal">4a-i when subjected to annulations using simple and inexpensive reagents such as formic acid, carbon disulfide and formamide afford title compounds 5a-i, <b style="mso-bidi-font-weight: normal">6a-i and 7a-i, respectively. The structures of all these previously unknown compounds have been established on the basis of spectral and analytical data. All synthesized compounds have been screened for their antimicrobial and antioxidant activities. Compounds 2b, 5d and <b style="mso-bidi-font-weight: normal">6a exhibit maximum zone of inhibition against the microorganisms E. coli, <i style="mso-bidi-font-style: normal">A. flavus and A. terrus whereas compound 7c shows maximum zone of inhibition against microbes E. coli, S. aureus, A. oryzae and<i style="mso-bidi-font-style: normal"> A. niger. Compounds 4h, 5g, <b style="mso-bidi-font-weight: normal">5h, 6g and 6h exhibit good radical scavenging activity as compared to the standards

Synthesis antimicrobial and antioxidant activities of some new 3-indolyl pyra­zolo[2,3-<i style="">c</i>]pyran and its derivatives^†

380-387Some new 6-amino-4-(2′,5′-disubstituted 1H-indol-3′-yl)-3-methyl-N1-isonicotinyl-1,4-dihydropyrano[2,3-c]pyrazoles have been synthesized and characterized by spectroscopic techniques (1H NMR, IR and MS) and elemental analysis. These compounds exhibit good antimicrobial and antioxidant activities on screening

Synthesis, antimicrobial and antioxidant activities of 2-oxo-6-phenyl-2-yl-4-(2′-phenyl-5′-substituted 1H-indol-3′-yl)-1,2-dihydro pyridin-3-carbonitriles and their derivatives

2-Oxo-4-(2′-phenyl-5′-substituted 1H-indol-3′-yl)-6-phenylpyridin-3-carbnitriles (2a–c) and its derivatives containing 1,2,4-triazole (4a–c), thiazolo[3,2-b][1,2,4]triazole (5a–c), hydrazide (6a–c), pyrazolones (7a–c) and (8a–c) were synthesized. Structures of all these previously unknown compounds were confirmed by their spectral studies and elemental analysis. The compounds were screened for their antioxidant and antimicrobial activities

Synthesis, Antioxidant, Antimicrobial, Antimycobacterial, and Cytotoxic Activities of Azetidinone and Thiazolidinone Moieties Linked to Indole Nucleus

2-N-(2-Phenyl-1H-indol-3-yl)imino-4-arylthiazoles (3a–c) were used as key synthons for the preparation of (4-arylthiazol-2-yl)-4-(2-phenyl-1H-indol-3-yl)azetidin-2-ones (4a–c) and 3-(4-arylthiazol-2-yl)-2-(2-phenyl-1H-indol-3-yl)thiazolidin-4-ones (5a–c). These newly synthesized compounds have been characterized with the help of IR, 1H NMR, 13C NMR, and mass spectral studies. All compounds were screened for their antioxidant, antimicrobial, antimycobacterial, and cytotoxic activities. Some of the compounds displayed excellent activity

Synthesis Antioxidant and Antimicrobial Activities of N-[(5′-Substituted 2′-phenyl-1H-indol-3′-yl)methylene]-5-(pyridin-4-yl)-1,3,4-oxadiazol-2-amines

The main aim of the present study was to develop antimicrobial and antioxidant compounds. As a part of systematic investigation, several new compounds 3a–c, 4a–c, and 5a–f were synthesized and screened for their biological activities. Compound 5f showed good zone of inhibition versus E. coli, S. aureus, and K. pneumoniae, whereas the compound 3a showed promising radical scavenging activity, ferric ions (Fe3+) reducing antioxidant power, and ferrous ions (Fe2+) metal chelating activity

SYNTHESIS, ANTIMICROBIAL AND ANTIOXIDANT ACTIVITIES OF SOME NEW 1&apos;-(10-SUBSTITUTED 5H, 6H, 7H-INDOLO[2,3-c]ISOQUINOLIN-5YLTHIO)FORMYL- 3&apos;,5&apos;-DISUBSTITUTED PYRAZOLES, -3&apos;-METHYLPYRAZOL-5&apos;-ONES AND -1&apos;,3&apos;,4&apos; OXIDIAZOL-2&apos;-THIONES #

Abstract The precursor ethyl(10-substituted 7H-indolo[2,3-c]isoquinolin-5-ylthio)formates (2a-c) were synthesized by reacting compounds (1a-c) with ethyl chloroformate. Compounds (2a-c) on treatment with hydrazine hydrate afforded (10-substituted 7H-indolo [2,3-c]isoquinolin-5-ylthio)carbohydrazides (3a-c). These hydrazides on cyclocodensation with acetyl acetone, dibenzoyl methane, ethyl acetoacetate and carbon disulphide afforded (10-substituted 7H-indolo[2,3-c]isoquinolin-5-ylthio)formyl-, -3&apos;,5&apos;-dimethyl/phenylpyrozoles (4a-f), -3&apos;-methylpyrozol-5&apos;-ones (5a-c) and 5&apos;-(10-substituted 7H-indolo [2,3-c]isoquinolin-5-ylthio) -1&apos;,3&apos;,4&apos;-oxidiazol-2&apos;-thiones (6a-c), respectively. The structures of these newly synthesized compounds were confirmed by their spectral studies and elemental analysis. These compounds were screened for their antimicrobial and antioxidant activities. Compounds 2a, 3a, 4a, 3e, 4b, 5c, 6b and 6c showed good antibacterial activity, whereas compounds 2c, 3a, 4a, 4c, 4e, 4f, 5a, 5b, 6a, 6b and 6c exhibited maximum zone of inhibition in case of antifungal activity. Compounds 2a, 3a, 3c, 4a, 4c, 4d, 4e, 5a, 5c, 6a and 6c showed good radical scavenging activity. Compounds 2a, 3c, 4a and 5a exhibited good reducing power activity, whereas the compounds 2a, 3a, 4a, 4c, 4f, 5a and 5b showed promising metal chelating activity when compared with standards