1,895 research outputs found
Mean Field Theory for Sigmoid Belief Networks
We develop a mean field theory for sigmoid belief networks based on ideas
from statistical mechanics. Our mean field theory provides a tractable
approximation to the true probability distribution in these networks; it also
yields a lower bound on the likelihood of evidence. We demonstrate the utility
of this framework on a benchmark problem in statistical pattern
recognition---the classification of handwritten digits.Comment: See http://www.jair.org/ for any accompanying file
Finite-Size Scaling of the Domain Wall Entropy Distributions for the 2D Ising Spin Glass
The statistics of domain walls for ground states of the 2D Ising spin glass
with +1 and -1 bonds are studied for square lattices with , and = 0.5, where is the fraction of negative bonds, using periodic
and/or antiperiodic boundary conditions. When is even, almost all domain
walls have energy = 0 or 4. When is odd, most domain walls have
= 2. The probability distribution of the entropy, , is found
to depend strongly on . When , the probability distribution
of is approximately exponential. The variance of this distribution
is proportional to , in agreement with the results of Saul and Kardar. For
the distribution of is not symmetric about zero. In
these cases the variance still appears to be linear in , but the average of
grows faster than . This suggests a one-parameter scaling
form for the -dependence of the distributions of for .Comment: 13 page
Global alterations to the choroid plexus blood-CSF barrier in amyotrophic lateral sclerosis
© 2020 The Author(s). The choroid plexus (CP) is a highly vascularized structure located in the ventricles that forms the blood-CSF barrier (BCSFB) and separates the blood from the cerebrospinal fluid (CSF). In addition to its role as a physical barrier, the CP functions in CSF secretion, transport of nutrients into the central nervous system (CNS) and a gated point of entry of circulating immune cells into the CNS. Aging and neurodegeneration have been reported to affect CP morphology and function and increase protein leakage from blood to the CSF. Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease associated with both upper and lower motor neuron loss, as well as altered proteomic and metabolomic signatures in the CSF. The role of the BCSFB and the CP in ALS is unknown. Here we describe a transcriptomic and ultrastructural analysis of BCSFB and CP alterations in human postmortem tissues from ALS and non-neurologic disease controls. ALS-CP exhibited widespread disruptions in tight junctional components of the CP epithelial layer and vascular integrity. In addition, we detected loss of pericytes around ALS blood vessels, accompanied by activation of platelet aggregation markers vWF and Fibrinogen, reminiscent of vascular injury. To investigate the immune component of ALS-CP, we conducted a comprehensive analysis of cytokines and chemokine panels in CP lysates and found a significant down-regulation of M-CSF and V-CAM1 in ALS, as well as up-regulation of VEGF-A protein. This phenotype was accompanied by an infiltration of MERTK positive macrophages into the parenchyma of the ALS-CP when compared to controls. Taken together, we demonstrate widespread structural and functional disruptions of the BCSFB in human ALS increasing our understanding of the disease pathology and identifying potential new targets for ALS therapeutic development
Searching for spectroscopic binaries within transition disk objects
S.A. Kohn acknowledges the support of NSF REU grant AST-1004107 through Northern Arizona University and Lowell Observatory. J. Llama acknowledges support from NASA Origins of the Solar System grant No. NNX13AH79G and from STFC grant ST/M001296/1. This research made use of the SIMBAD database, operated at CDS, Strasbourg, France.Transition disks (TDs) are intermediate stage circumstellar disks characterized by an inner gap within the disk structure. To test whether these gaps may have been formed by closely orbiting, previously undetected stellar companions, we collected high-resolution optical spectra of 31 TD objects to search for spectroscopic binaries (SBs). Twenty-four of these objects are in Ophiuchus and seven are within the Coronet, Corona Australis, and Chameleon I star-forming regions. We measured radial velocities for multiple epochs, obtaining a median precision of 400 msâ1. We identified double-lined SB SSTc2d J163154.7â250324 in Ophiuchus, which we determined to be composed of a K7(±0.5) and a K9(±0.5) star, with orbital limits of a < 0.6 au and P < 150 days. This results in an SB fraction of in Ophiuchus, which is consistent with other spectroscopic surveys of non-TD objects in the region. This similarity suggests that TDs are not preferentially sculpted by the presence of close binaries and that planet formation around close binaries may take place over similar timescales to that around single stars.Publisher PDFPeer reviewe
What happens to ART-eligible patients who do not start ART? Drop out between screening and ART initiation: a cohort study in Karonga, Malawi
BACKGROUND: Routine ART programme statistics generally only provide information about individuals who start treatment. We aimed to investigate the outcome of those who are eligible but do not start ART in the Malawi programme, factors associated with this dropout, and reasons for not starting treatment, in a prospective cohort study.METHODS: Individuals having a first screening visit at the ART clinic at Karonga District Hospital, northern Malawi, between September 2005 and July 2006 were interviewed. Study follow-up to identify treatment outcomes was conducted at the clinic and in the community. Logistic regression models were used to identify factors associated with dropout before ART initiation among participants identified as clinically eligible for ART.RESULTS: 88 participants eligible for ART at their first screening visit (out of 633, 13.9%) defaulted before starting ART. Participants with less education, difficulties in dressing, a more delayed ART initiation appointment, and mid-upper arm circumference (MUAC) < 22 cm were significantly less likely to have visited the clinic subsequently. Thirty-five (58%) of the 60 participants who defaulted and were tracked at home had died, 21 before their ART initiation appointment.CONCLUSIONS: MUAC and reported difficulties in dressing may provide useful screening indicators to identify sicker ART-eligible individuals at high risk of dropping out of the programme who might benefit from being brought back quickly or admitted to hospital for observation. Individuals with less education may need adapted health information at screening. Deaths of ART-eligible individuals occurring prior to ART initiation are not included in routine programme statistics. Considering all those who are eligible for ART as a denominator for programme indicators would help to highlight this vulnerable group, in order to identify new opportunities for further improving ART programmes
Implementing an apparent-horizon finder in three dimensions
Locating apparent horizons is not only important for a complete understanding
of numerically generated spacetimes, but it may also be a crucial component of
the technique for evolving black-hole spacetimes accurately. A scheme proposed
by Libson et al., based on expanding the location of the apparent horizon in
terms of symmetric trace-free tensors, seems very promising for use with
three-dimensional numerical data sets. In this paper, we generalize this scheme
and perform a number of code tests to fully calibrate its behavior in
black-hole spacetimes similar to those we expect to encounter in solving the
binary black-hole coalescence problem. An important aspect of the
generalization is that we can compute the symmetric trace-free tensor expansion
to any order. This enables us to determine how far we must carry the expansion
to achieve results of a desired accuracy. To accomplish this generalization, we
describe a new and very convenient set of recurrence relations which apply to
symmetric trace-free tensors.Comment: 14 pages (RevTeX 3.0 with 3 figures
A Scalable Kernel-Based Semisupervised Metric Learning Algorithm with Out-of-Sample Generalization Ability
A Ca2+-activated potassium channel (BKCa) in Leydig cells is involved in testosterone production
Previously, we found that human steroid-producing ovarian granulosa cells express all major types of Ca2+-activated potassium channels (KCa), including BKCa, IK and SKs (Traut et al., RB&E, 2009), and that modulation of the activity of these channels resulted in alteration of steroid production. In the male gonad Leydig cells produce androgens, but whether these cells are endowed with KCas is not known. We addressed these points and focussed on BKCa, which is Ca2+-activated and the underlying channel for a prominent current. It can be manipulated, e.g. by a specific blocker, the red scorpion toxin iberiotoxin (IbTx), which binds to the outer face with high affinity and selectively inhibits the current by decreasing both the probability of opening and the open time of the channel.Fil: Siebert, S. Ludwig Maximilians UniversitĂ€t MĂŒnchen. ; AlemaniaFil: Spinnler, K. Ludwig Maximilians UniversitĂ€t MĂŒnchen. ; AlemaniaFil: Matzkin, Maria Eugenia. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Instituto de BiologĂa y Medicina Experimental. FundaciĂłn de Instituto de BiologĂa y Medicina Experimental. Instituto de BiologĂa y Medicina Experimental; ArgentinaFil: Kunz, L. Ludwig Maximilians UniversitĂ€t MĂŒnchen. ; AlemaniaFil: Calandra, Ricardo Saul. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Instituto de BiologĂa y Medicina Experimental. FundaciĂłn de Instituto de BiologĂa y Medicina Experimental. Instituto de BiologĂa y Medicina Experimental; ArgentinaFil: Frungieri, Monica Beatriz. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Instituto de BiologĂa y Medicina Experimental. FundaciĂłn de Instituto de BiologĂa y Medicina Experimental. Instituto de BiologĂa y Medicina Experimental; ArgentinaFil: Mayerhofer, A. Ludwig Maximilians UniversitĂ€t MĂŒnchen. ; Alemania22. Jahrestagung der Deutschen Gesellschaft fĂŒr Andrologie e VHamburgoAlemaniaDeutsche Gesellschaft fĂŒr AndrologieConventus Congressmanagement und Marketing Gmb
Finite-Size Scaling in the Energy-Entropy Plane for the 2D +- J Ising Spin Glass
For square lattices with the 2D Ising spin glass with
+1 and -1 bonds is found to have a strong correlation between the energy and
the entropy of its ground states. A fit to the data gives the result that each
additional broken bond in the ground state of a particular sample of random
bonds increases the ground state degeneracy by approximately a factor of 10/3.
For (where is the fraction of negative bonds), over this range of
, the characteristic entropy defined by the energy-entropy correlation
scales with size as . Anomalous scaling is not found for the
characteristic energy, which essentially scales as . When , a
crossover to scaling of the entropy is seen near . The results
found here suggest a natural mechanism for the unusual behavior of the low
temperature specific heat of this model, and illustrate the dangers of
extrapolating from small .Comment: 9 pages, two-column format; to appear in J. Statistical Physic
Generating droplets in two-dimensional Ising spin glasses by using matching algorithms
We study the behavior of droplets for two dimensional Ising spin glasses with
Gaussian interactions. We use an exact matching algorithm which enables study
of systems with linear dimension L up to 240, which is larger than is possible
with other approaches. But the method only allows certain classes of droplets
to be generated. We study single-bond, cross and a category of fixed volume
droplets as well as first excitations. By comparison with similar or equivalent
droplets generated in previous works, the advantages but also the limitations
of this approach are revealed. In particular we have studied the scaling
behavior of the droplet energies and droplet sizes. In most cases, a crossover
of the data can be observed such that for large sizes the behavior is
compatible with the one-exponent scenario of the droplet theory. Only for the
case of first excitations, no clear conclusion can be reached, probably because
even with the matching approach the accessible system sizes are still too
small.Comment: 11 pages, 16 figures, revte
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