Persistence of a Rouse polymer chain under transverse shear flow

We consider a single Rouse polymer chain in two dimensions in presence of a transverse shear flow along the $x$ direction and calculate the persistence probability $P_0(t)$ that the $x$ coordinate of a bead in the bulk of the chain does not return to its initial position up to time $t$. We show that the persistence decays at late times as a power law, $P_0(t)\sim t^{-\theta}$ with a nontrivial exponent $\theta$. The analytical estimate of $\theta=0.359...$ obtained using an independent interval approximation is in excellent agreement with the numerical value $\theta\approx 0.360\pm 0.001$.Comment: 6 page

Intent-Aware Contextual Recommendation System

Recommender systems take inputs from user history, use an internal ranking algorithm to generate results and possibly optimize this ranking based on feedback. However, often the recommender system is unaware of the actual intent of the user and simply provides recommendations dynamically without properly understanding the thought process of the user. An intelligent recommender system is not only useful for the user but also for businesses which want to learn the tendencies of their users. Finding out tendencies or intents of a user is a difficult problem to solve. Keeping this in mind, we sought out to create an intelligent system which will keep track of the user's activity on a web-application as well as determine the intent of the user in each session. We devised a way to encode the user's activity through the sessions. Then, we have represented the information seen by the user in a high dimensional format which is reduced to lower dimensions using tensor factorization techniques. The aspect of intent awareness (or scoring) is dealt with at this stage. Finally, combining the user activity data with the contextual information gives the recommendation score. The final recommendations are then ranked using filtering and collaborative recommendation techniques to show the top-k recommendations to the user. A provision for feedback is also envisioned in the current system which informs the model to update the various weights in the recommender system. Our overall model aims to combine both frequency-based and context-based recommendation systems and quantify the intent of a user to provide better recommendations. We ran experiments on real-world timestamped user activity data, in the setting of recommending reports to the users of a business analytics tool and the results are better than the baselines. We also tuned certain aspects of our model to arrive at optimized results.Comment: Presented at the 5th International Workshop on Data Science and Big Data Analytics (DSBDA), 17th IEEE International Conference on Data Mining (ICDM) 2017; 8 pages; 4 figures; Due to the limitation "The abstract field cannot be longer than 1,920 characters," the abstract appearing here is slightly shorter than the one in the PDF fil

Analiza strukturne funkcije nukleona

The square modulus of the wave function of the proton has been derived in the framework of the statistical model. The presence of antiquarks in the sea, which simulates the screening effect, has been explicitly taken into account. The resulting momentum space wavefunction has also been used to estimate the structure function for the free proton as well as the difference in structure function for the proton and neutron. The results obtained are in agreement with the corresponding experimental data and other theoretical estimates. The colour transparency effect has also been studied with interesting consequences.U okviru statističkog modela izveden je izraz za kvadrat modula valne funkcije. Eksplicitno je uzeta u obzir prisutnost antikvarkova iz pozadine koja simulira efekt zasjenjenja. Pomoću Fourierovog transformata valne funkcije određena je strukturna funkcija slobodnog protona i razlika strukturnih funkcija protona i neutrona. Dobiveni rezultati slažu se s odgovarajućim eksperimentalnim vrijednostima i rezultatima drugih teorijskih ocjena. Proučava se, takoder, efekt transparencije boje i izvedene su neke zanimljive posljedice

Analiza strukturne funkcije nukleona

The square modulus of the wave function of the proton has been derived in the framework of the statistical model. The presence of antiquarks in the sea, which simulates the screening effect, has been explicitly taken into account. The resulting momentum space wavefunction has also been used to estimate the structure function for the free proton as well as the difference in structure function for the proton and neutron. The results obtained are in agreement with the corresponding experimental data and other theoretical estimates. The colour transparency effect has also been studied with interesting consequences.U okviru statističkog modela izveden je izraz za kvadrat modula valne funkcije. Eksplicitno je uzeta u obzir prisutnost antikvarkova iz pozadine koja simulira efekt zasjenjenja. Pomoću Fourierovog transformata valne funkcije određena je strukturna funkcija slobodnog protona i razlika strukturnih funkcija protona i neutrona. Dobiveni rezultati slažu se s odgovarajućim eksperimentalnim vrijednostima i rezultatima drugih teorijskih ocjena. Proučava se, takoder, efekt transparencije boje i izvedene su neke zanimljive posljedice

Ward based goal directed fluid therapy (GDFT) in acute pancreatitis (GAP) trial: A feasibility randomised controlled trial

Background: Goal-directed fluid therapy (GDFT) reduces complications in patients undergoing major general surgery. There are no reports of cardiac output evaluation being used to optimise the fluid administration for patients with acute pancreatitis (AP) in a general surgery ward. / Method: 50 patients with AP were randomised to either ward-based GDFT (n = 25) with intravenous (IV) fluids administered based on stroke volume optimisation protocol or standard care (SC) (n = 25), but with blinded cardiac output evaluation, for 48-h following hospital admission. Primary outcome was feasibility. / Results: 50 of 116 eligible patients (43.1%) were recruited over 20 months demonstrating feasibility. 36 (72%) completed the 48-h of GDFT; 10 (20%) discharged within 48-h and 4 withdrawals (3 GDFT, 1 SC). Baseline characteristics were similar with only 3 participants having severe disease (6%, 1 GDFT, 2 SC). Similar volumes of IV fluids were administered in both groups (GDFT 5465 (1839) ml, SC 5211 (1745) ml). GDFT group had a lower heart rate, blood pressure and respiratory rate and improved oxygen saturations. GDFT was not associated with any harms. There was no evidence of difference in complications of AP (GDFT 24%, SC 32%) or in the duration of stay in intensive care (GDFT 0 (0), SC 0.7 (3) days). Length of hospital stay was 5 (2.9) days in GDFT and 6.3 (7.6) in SC groups. / Conclusion: Ward-based GDFT is feasible and shows a signal of possible efficacy in AP in this early-stage study. A larger multi-site RCT is required to confirm clinical and cost effectiveness

Random Convex Hulls and Extreme Value Statistics

In this paper we study the statistical properties of convex hulls of $N$ random points in a plane chosen according to a given distribution. The points may be chosen independently or they may be correlated. After a non-exhaustive survey of the somewhat sporadic literature and diverse methods used in the random convex hull problem, we present a unifying approach, based on the notion of support function of a closed curve and the associated Cauchy's formulae, that allows us to compute exactly the mean perimeter and the mean area enclosed by the convex polygon both in case of independent as well as correlated points. Our method demonstrates a beautiful link between the random convex hull problem and the subject of extreme value statistics. As an example of correlated points, we study here in detail the case when the points represent the vertices of $n$ independent random walks. In the continuum time limit this reduces to $n$ independent planar Brownian trajectories for which we compute exactly, for all $n$, the mean perimeter and the mean area of their global convex hull. Our results have relevant applications in ecology in estimating the home range of a herd of animals. Some of these results were announced recently in a short communication [Phys. Rev. Lett. {\bf 103}, 140602 (2009)].Comment: 61 pages (pedagogical review); invited contribution to the special issue of J. Stat. Phys. celebrating the 50 years of Yeshiba/Rutgers meeting

Systemic chemotherapy with or without cetuximab in patients with resectable colorectal liver metastasis (New EPOC): long-term results of a multicentre, randomised, controlled, phase 3 trial.

BACKGROUND: The interim analysis of the multicentre New EPOC trial in patients with resectable colorectal liver metastasis showed a significant reduction in progression-free survival in patients allocated to cetuximab plus chemotherapy compared with those given chemotherapy alone. The focus of the present analysis was to assess the effect on overall survival. METHODS: New EPOC was a multicentre, open-label, randomised, controlled, phase 3 trial. Adult patients (aged ≥18 years) with KRAS wild-type (codons 12, 13, and 61) resectable or suboptimally resectable colorectal liver metastases and a WHO performance status of 0-2 were randomly assigned (1:1) to receive chemotherapy with or without cetuximab before and after liver resection. Randomisation was done centrally with minimisation factors of surgical centre, poor prognosis cancer, and previous adjuvant treatment with oxaliplatin. Chemotherapy consisted of oxaliplatin 85 mg/m2 administered intravenously over 2 h, l-folinic acid (175 mg flat dose administered intravenously over 2 h) or d,l-folinic acid (350 mg flat dose administered intravenously over 2 h), and fluorouracil bolus 400 mg/m2 administered intravenously over 5 min, followed by a 46 h infusion of fluorouracil 2400 mg/m2 repeated every 2 weeks (regimen one), or oxaliplatin 130 mg/m2 administered intravenously over 2 h and oral capecitabine 1000 mg/m2 twice daily on days 1-14 repeated every 3 weeks (regimen two). Patients who had received adjuvant oxaliplatin could receive irinotecan 180 mg/m2 intravenously over 30 min with fluorouracil instead of oxaliplatin (regimen three). Cetuximab was given intravenously, 500 mg/m2 every 2 weeks with regimen one and three or a loading dose of 400 mg/m2 followed by a weekly infusion of 250 mg/m2 with regimen two. The primary endpoint of progression-free survival was published previously. Secondary endpoints were overall survival, preoperative response, pathological resection status, and safety. Trial recruitment was halted prematurely on the advice of the Trial Steering Committee on Nov 1, 2012. All analyses (except safety) were done on the intention-to-treat population. Safety analyses included all randomly assigned patients. This trial is registered with ISRCTN, number 22944367. FINDINGS: Between Feb 26, 2007, and Oct 12, 2012, 257 eligible patients were randomly assigned to chemotherapy with cetuximab (n=129) or without cetuximab (n=128). This analysis was carried out 5 years after the last patient was recruited, as defined in the protocol, at a median follow-up of 66·7 months (IQR 58·0-77·5). Median progression-free survival was 22·2 months (95% CI 18·3-26·8) in the chemotherapy alone group and 15·5 months (13·8-19·0) in the chemotherapy plus cetuximab group (hazard ratio [HR] 1·17, 95% CI 0·87-1·56; p=0·304). Median overall survival was 81·0 months (59·6 to not reached) in the chemotherapy alone group and 55·4 months (43·5-71·5) in the chemotherapy plus cetuximab group (HR 1·45, 1·02-2·05; p=0·036). There was no significant difference in the secondary outcomes of preoperative response or pathological resection status between groups. Five deaths might have been treatment-related (one in the chemotherapy alone group and four in the chemotherapy plus cetuximab group). The most common grade 3-4 adverse events reported were: neutrophil count decreased (26 [19%] of 134 in the chemotherapy alone group vs 21 [15%] of 137 in the chemotherapy plus cetuximab group), diarrhoea (13 [10%] vs 14 [10%]), skin rash (one [1%] vs 22 [16%]), thromboembolic events (ten [7%] vs 11 [8%]), lethargy (ten [7%] vs nine [7%]), oral mucositis (three [2%] vs 14 [10%]), vomiting (seven [5%] vs seven [5%]), peripheral neuropathy (eight [6%] vs five [4%]), and pain (six [4%] vs six [4%]). INTERPRETATION: Although the addition of cetuximab to chemotherapy improves the overall survival in some studies in patients with advanced, inoperable metastatic disease, its use in the perioperative setting in patients with operable disease confers a significant disadvantage in terms of overall survival. Cetuximab should not be used in this setting. FUNDING: Cancer Research UK

Advent of Industrial Mass Production: Three Stages of Economic Development

This paper develops a human-capital-based endogenous growth scenario in which an economy initially produces the agricultural good, characterized by diminishing returns to scale, then produces `traditional manufacturing' under constant-returns and finally produces `modern manufacturing' under increasing-returns. Transition dates are endogenous and depend on the non-essentiality of the industrial goods in preferences and fixed costs in the technology of the modern manufacturing. Each transition is followed by a jump in the long-run growth rate of real income. The theoretical model is calibrated to U.S. historical data. It `predicts' the first transition to occur around 1820s and the second transition to happen around 1900.