ヒト陰茎扁平上皮癌培養細胞株TSUS-1の樹立とその性状

37歳男性の電撃型陰茎癌患者の転移を認めた心嚢液よりヒト陰茎扁平上皮癌培養細胞株TSUS-1を樹立した.継代培養は60代におよび2年5ヵ月を経過した現在なお増殖を続けており, ヌードマウス皮下移植率は100%であった.継代培養40代の染色体分析でモード75の低四倍体で, マーカー染色体を7個認めた.ヌードマウス移植腫瘍は皮膚に浸潤し, 角化傾向も著明で, 原発巣の陰茎癌類似の肉眼的所見を示し, 組織学的には癌真珠を含む角化傾向を散見する扁平上皮癌で, 原発陰茎癌に類似していたWe established a cell line ( TSUS -1) derived from a relatively well-differentiated squamous cell carcinoma of the penis. The cells had been subcultured 60 times during two years and five months. The average doubling time of this cell line was 38 hours. Chromosomal analysis indicated that the modal chromosome number was 75; seven marker chromosomes and a male karyotype were present. The cultured cells were easily transplantable into BALB/c nude mice and the histological picture of the inoculated tumor was similar to that of the original tumor

Increase of S-100 protein-positive stellate cells in the anterior pituitary of chronic alcoholic patients with fatty liver or fatty cirrhosis.

Healthy subjects 40 years old were used as controls in a study of stellate cells (S-100 protein-containing cells, or S-100 cells) in subjects with chronic alcoholism and fatty liver or fatty cirrhosis. S-100 cells were sparsely found in the adenohypophysis of control subjects, and these cells sometimes formed small clusters. However, in chronic alcoholics with fatty liver or fatty cirrhosis, the number of stellate cells in the anterior pituitary tended to be 17 times higher than it was in the control group. No increase in the number of S-100 positive cells that constitute the large and small follicles in the intermediate pituitary. The physiological function of the S-100 protein has not yet been identified. The fact that an increase in prolactin-secreting and growth hormone-secreting cells, as well as a decrease in gonadotrophs were observed in the hypophysis of alcoholics suggests that the function of stellate cells may be closely related to these phenomena. Our results also imply that the stellate cells found in the anterior and intermediate pituitary differ in function although they both produce S-100 proteins.</p

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RELATION BETWEEN RELEASE PARAMETERS AND THROWING DISTANCE OF THE JAVELIN THROW

The present study was clarified a three-dimensional examination of the relation between the release parameters and throwing distances, in order to understand the initial flight characteristics of javelins. The subjects were 57 right-handed javelin throwers. The measured throwing distances ranged from 45.25 m to 87.17 m. The elite throwers had tendency to significant positive correlation between theoretical distance and initial velocity of javelin release. Throwers who achieved throwing distances of over 70m were observed to have throwing distances that were shorter than their theoretical distances, while those whose throwing distances were under 70 m group had throwing distances that were longer than their theoretical distances. When the data were applied to initial velocity of javelin release, it was equivalent to 26 m/s

Continuous Transition between Antiferromagnetic Insulator and Paramagnetic Metal in the Pyrochlore Iridate Eu2Ir2O7

Our single crystal study of the magneto-thermal and transport properties of the pyrochlore iridate Eu2Ir2O7 reveals a continuous phase transition from a paramagnetic metal to an antiferromagnetic insulator for a sample with stoichiometry within ~1% resolution. The insulating phase has strong proximity to an antiferromagnetic semimetal, which is stabilized by several % level of the off-stoichiometry. Our observations suggest that in addition to electronic correlation and spin-orbit coupling the magnetic order is essential for opening the charge gap.Comment: 6 pages, 6 figure

Role of adenohypophyseal mixed cell-follicles in age estimation.

In this study we used paraffin-embedded human pituitary obtained from 248 autopsy cases and identified mixed cell follicles by the immunohistochemical method. We examined the number and size of the mixed cell follicles, and the ratio of each component cell of these follicles, in the anterior pituitary at various age groups. The number of follicles increased with age, and the size of the follicles also tended to enlarge with age. Statistical analysis showed that a high correlation existed between age and the number or the size of the mixed cell-follicles formed by various adenohypophyseal cells. In addition, when the proportions of the different cell types that formed the follicles were examined, sex differences were observed with aging for the GH cells, the PRL cells, and the gonadotroph (GTH) cells, while no changes were observed with aging in both men and women for the ACTH cells and TSH cells. These results indicate that the number, size, and ratio of each component cell of follicles in the anterior pituitary are adequately applicable for the purpose of age estimation in routine forensic medicine.</p