A prospective randomized study: role of enalapril on oxidative stress in newly diagnosed type 2 diabetes mellitus and its correlation with glycaemic status

Background: Oxidative stress is demonstrated the pathological conditions such as Atherosclerosis and diabetes mellitus. It has been suggested to be involved in the pathogenesis of both macro and microvascular complications. This study was designed to evaluate the effect of Enalapril on oxidative stress markers in type 2 diabetic patients.Methods: A Prospective Randomized controlled study was conducted in 75 participants in which 25 healthy volunteers and 50 newly diagnosed DM2 patients who were divided into three groups of 25 in each. In Group II DM2 patients were treated with Metformin alone, in group III DM2 patients were treated with Enalapril and Metformin and 25 healthy volunteers were included in Group I (controls). Oxidative stress parameters, FBS, HbA1c were measured at the time of diagnosis and at 4,8,12 weeks.Results: There was a significant decrease in free radical production (p<0.05) and significant increase in antioxidant enzymes (p<0.001) in both the patient Groups and positive correlation between oxidative stress markers and FBS and HbA1c (p<0.01).Conclusions: Oxidative stress measured as LPO is strictly influenced by glycaemic control. Enalapril and Metformin combination in diabetic patients has more significant effect on decreasing the oxidative stress than Metformin alone

Effectiveness of ginger extract to reduce nausea, vomiting and regurgitation among pregnant mothers in selected community setting.

A study to asses the effectiveness of ginger Extracts to relieve nausea vomiting and regurgitation Among pregnant mothers. OBJECTIVES: To assess the health status of the antenatal mothers. To assess the effectiveness of the ginger tea in reduction of morning sickness among antenatal mothers. To find out the association between selected demographic variables and effectiveness of ginger extracts to relieve nausea, vomiting and regurgitation among antenatal mothers OPERATIONAL DEFINITIONS: Effectiveness Refers to the impact of ginger extract and the level of nausea vomiting and regurgitation among pregnant mothers assessed with Rhodes of nausea vomiting scales. Ginger extract: Refers to an ginger extract made from one gram of fresh ginger is sliced, grinded and filtered and the extract is added with 10ml of honey and made into 15ml of ginger extract and orally administered to the pregnant mother after breakfast for 5days. Nausea: Refers to the sensation of discomfort to vomiting in the gastrointestinal tract experienced by the pregnant mother during the early period of pregnancy Vomiting: It is the vigorous expulsion of gastric contents through the mouth and nose experienced by the pregnant mother throughout 24 hours and measured by Rhodes index of nausea vomiting regurgitation. Regurgitation: Refers to strong unproductive and involuntary effect to vomiting whereby the indigested gastric content felt in the pharynx by the pregnant mother. PREGNANT MOTHER: Refers to the pregnant mothers between 6 and 17 weeks of gestation who experienced nausea vomitingand regurgitation during pregnancy. VARIABLES: Independent Variable Ginger extract Dependent Variable Nausea, vomiting and regurgitation ASSUMPTION: There is a significant relationship between the demographic variables with the effectiveness of ginger extract to reduce nausea, vomiting and regurgitation among pregnant mothers. Ginger may have some effect on level of Nausea vomiting and regurgitation among pregnant mothers LIMITATIONS: 1. the study has been limited to a period of 4weeks of data collection 2. the study has been delimited to selected villages of Kanchipuram district PROJECTED OUTCOME: The nurse can use ginger as an alternative medicine to treat Nausea vomiting and regurgitation during pregnancy which will be a health promoting activity in maternal and child health services. Pregnant mothers will be relieved from the disorder of pregnancy and enhance better nutritional status during pregnancy

Influence of nitrogen application on direct seeded rice in old and new Cauvery Delta zone of Tamil Nadu, India

Direct seeded rice is a boon to farmers where the water release from the reservoir is delayed. Nitrogen fertiliser management is one of the strategies bto rectify the nutrient-related issue in Direct seeded rice. The present study aimed to optimize the nitrogen dose for direct-seeded rice in the new and old Cauvery delta zone of Tamil Nadu. Field experiments were conducted during kuruvai and samba seasons at Tamil Nadu Rice Research Institute, Aduthurai and Agricultural research station Thanjavur representing old and new Cauvery delta regions during 2019-20 and 2020-21. Totally from eight experiments, the results of four field experiments in each location revealed the highest grain yield in the treatment T6 -application of 150 kg Nha-1 (5596kg/ha) which was statistically on par with treatment T5 -125kg N/ha (5326 kg/ha) in old delta and new delta. The higher grain yield was recorded in the T6 (5140 kg/ha), statistically on par with T5 (4550 kg/ha). The higher available nitrogen content of 312 kg/ ha,292 kg/ha was recorded for N application @ 150kg/ha, which was statistically on par with  309 kg/ha and 289 kg/ha, respectively, both the kuruvai and samba seasons for N application of 125 kg/ha. In the new CDZ, the same trend was followed as that of the old delta. Based on economics, N applied @125 kg/ha recorded a higher BC ratio for direct-seeded rice. For the benefit of farmers of both deltaic regions, the nitrogen application of 125 kg ha-1 for direct-seeded rice is recommended

Laparoscopic management of ileal endometriosis: presented as sub-acute intestinal obstruction

Patients with bowel endometriosis will usually experience a long delay in getting diagnosed as the physician will always think of other medical conditions related to bowel before considering the possibility of endometriosis. Imaging studies are not sensitive enough for definite diagnosis. Bowel endometriosis can be treated by either hormone therapy or surgical therapy. Surgery should be considered in selected patients, who have severe stenosis of intestinal lumen resulting in obstruction. Small bowel endometriosis may not be accompanied by pelvic endometriosis. When the disease involves the jejunum or the ileum, it usually has a benign course, but in rare circumstances may present as an acute abdomen. Ileal endometriosis should be carefully considered in the differential diagnosis of Crohn’s disease, because bowel endometriosis frequently produces local inflammation, adhesions, stricture and angulation. A segmental bowel resection may be required to completely treat their disease. The role of postoperative administration of gonadotropin releasing hormone analogues (GnRH) to prevent disease recurrence or increase symptom free interval is not well established

Trends and risk factors for childhood diarrhea in sub-Saharan countries (1990 2013): assessing the neighborhood inequalities

BACKGROUND: Diarrheal diseases are a major cause of child mortality and one of the main causes of medical consultation for children in sub-Saharan countries. This paper attempts to determine the risk factors and neighborhood inequalities of diarrheal morbidity among under-5 children in selected countries in sub- Saharan Africa over the period 1990 2013. DESIGN: Data used come from the Demographic and Health Survey (DHS) waves conducted in Burkina Faso (1992 93, 1998 99, 2003, and 2010), Mali (1995, 2001, 2016, and 2012), Nigeria (1990, 1999, 2003, 2008, and 2013), and Niger (1992, 1998, 2006, and 2012). Bivariate analysis was performed to assess the association between the dependent variable and each of the independent variables. Multilevel logistic regression modelling was used to determine the fixed and random effects of the risk factors associated with diarrheal morbidity. RESULTS: The findings showed that the proportion of diarrheal morbidity among under-5 children varied considerably across the cohorts of birth from 10 to 35%. There were large variations in the proportion of diarrheal morbidity across countries. The proportions of diarrheal morbidity were higher in Niger compared with Burkina Faso, Mali, and Nigeria. The risk factors of diarrheal morbidity varied from one country to another, but the main factors included the child's age, size of the child at birth, the quality of the main floor material, mother's education and her occupation, type of toilet, and place of residence. The analysis shows an increasing trend of diarrheal inequalities according to DHS rounds. In Burkina Faso, the value of the intraclass correlation coefficient (ICC) was 0.04 for 1993 DHS and 0.09 in 2010 DHS; in Mali, the ICC increased from 0.04 in 1995 to 0.16 in 2012; in Nigeria, the ICC increased from 0.13 in 1990 to 0.19 in 2013; and in Niger, the ICC increased from 0.07 in 1992 to 0.11 in 2012.IS

IN VITRO AND IN VIVO PROTECTIVE EFFECTS OF AMBREX, A POLYHERBAL FORMULATION, AGAINST METHOTREXATE INDUCED DAMAGES IN HEPATIC CELLS

Objective: To evaluate the hepatoprotective effect of Ambrex, a poly herbal formulation against methotrexate (MTX) induced hepatotoxicity in Swiss albino mice as well as in Chang liver cell lines.Methods: Ambrex was exposed to MTX intoxicated chang liver cells and cells were harvested for studying the gene expressions of Dihydrofolate reductase (DHFR), B-cell lymphoma 2 (BCL2) and Bcl-2-associated X protein (BAX). In in vivo study, Ambrex was administered orally for a period of 7 days at two dose levels (250 and 500 mg/kg b. wt) and MTX (20 mg/kg b. wt, i. p) was injected one hour after the last test drug administration. Protective effect of Ambrex was evaluated by measuring aspartate transaminase (SGOT), alanine transaminase (SGPT), alkaline phosphatase (ALP), γ–glutamyl transferase (γGT) and total bilirubin. Its effect on superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH) and lipid peroxide (LPO) was also determined.Results: Data revealed that Ambrex was able to restore the levels of antioxidants such as SOD, Catalase, and Glutathione to near normal and reduced the elevated plasma levels of SGOT, SGPT, ALP, γ–GT and total bilirubin. It also inhibited the formation of hepatic malondialdehyde induced by MTX. In vitro studies revealed that Ambrex protected MTX induced hepatotoxicity at the dose of 50 and 500ng/ml. Further, mRNA expression also illustrated that Ambrex inhibited the over expression of BAX and suppressed BCL2 and DHRF expressions.Conclusion: Results suggest that Ambrex has potent hepatoprotective effect which was evident from both in vivo and in vitro results.Â

Estimation of soil carbon pools under major cropping systems of Mayiladuthurai district of Cauvery Delta Zone, Tamil Nadu, India

Soil organic carbon (SOC) is a potential indicator of soil quality and ecosystem sustainability. The present study aimed to evaluate SOC pools under major cropping systems of Mayiladuthurai district of Tamil Nadu. The composite samples were collected from two depths (0-15 and 15-30 cm) by stratified random sampling and were analysed for pH, EC (Electrical conductivity), C fractions, inorganic carbon and permanganate oxidisable carbon by standard procedures. The SOC content under different land use was in the order of Forestry &gt; Rice – pulses &gt; Rice – cotton &gt; Sugarcane &gt; Uncultivated. The mean SOC content of the study area was 12.58 Mg ha-1, where the majority of the area falls under low to medium rating of SOC. Hence, cultivation practices should incorporate activities that increase SOC to maintain soil quality. SOC was positively correlated with fractions of carbon – CVL (r = 0.37**), CL (r = 0.65**) and CLL (r = 0.58**), indicating changes in land use would affect the carbon dynamics of the ecosystem. The root biomass, aeration status, microbial activity, nutrient reserves and inherent soil characteristics influenced SOC to decrease with depth. The PCA analysis revealed that the variation in carbon dynamics of the study area was influenced by SOC, CLC, CLL and non-labile carbon due to differences in land management practices. Therefore, such soil management practices will be a powerful tool to sequester carbon, which supplements climate change mitigation

Study of changes in non-stress test following antenatal corticosteroid therapy in preterm pregnancy

Background: Preterm birth is the largest unsolved problem in obstetrics and the single most significant cause of neonatal morbidity and mortality. Preterm labour constitutes 5-10% of pregnancies and is the leading cause of neonatal morbidity and mortality worldwide. It is a major public health problem in terms of loss of life, long term disability (cerebral palsy, blindness, deafness, chronic lung disease). The objectives of this study were to determine whether antenatal corticosteroid administration affects the non-stress test. To evaluate the effect of antenatal steroid on foetal movements. To assess the incidence of respiratory distress syndrome and neonatal mortality after antenatal corticosteroid administration.Methods: All antenatal cases between 28-32 weeks of gestation judged to be at risk for preterm delivery attending the outpatient department or admitted in a tertiary care hospital, Tamil Nadu during the study period of 3 years.Results: The present study was undertaken to evaluate the NST for a period of 3 days following antenatal corticosteroid administration and to study the immediate changes in the mother and the foetus. We found out that there was a statistically significant change (p <0.01) in non-stress test when compared with the pre-betamethasone assay.Conclusions: Corticosteroids can cause metabolic alterations in mother, short- and long-term effect in the foetus

EFFECT OF CHICORY LEAF EXTRACT SEED HARDENING CUM FOLIAR SPRAY TO IMPROVE RESULTANT SEED QULAITY IN SESAME (Sesamum indicum L.) cv. TMV 3 UNDER RAINFED CONDITION.

An evaluation was carried out to study the effect pre sowing seed treatment and foliar spay with chicory leaf extract on resultant seed quality characters of sesame cv TMV 3. The bulk seeds were graded for uniformity using appropriate round perforated metal sieves of sizes of 5/64" size sieve and were imposed various concentration of chicory leaf extract presowing treatment coupled with foliar spray at different concentration under drought condition. After harvest the resultant seeds were evaluated for its seed qualities. The results revealed that the that the Chicory @ 20 % Pre sowing seed treatment + Chicory foliar spray @ 30 %&nbsp; during pod filling stage&nbsp; significantly increased the resultant seed quality characters of the sesame, when compared to other concentration and control