On the importance of being flexible: early interrelations between affective flexibility, executive functions and anxiety symptoms in preschoolers

When children are confronted with an emotional problem, affective flexibility mobilizes their cognitive and emotional resources to optimally address it. We investigated the contribution of executive functions to cognitive and affective flexibility in preschoolers. We assessed affective flexibility in 67 preschoolers (30 girls; Mmonths = 61.77, SD = 11.08 months) using an innovative measure – the Emotional Flexible Item Selection Task (EM-FIST), plus cool measures of executive functions (working memory, inhibition and cognitive flexibility), anxiety symptoms and intelligence. Findings revealed that affective flexibility improves during the preschool years. While individual differences in age and proactive inhibition predicted cognitive flexibility, a different constellation of predictors (maternal education, proactive inhibition, working memory and age) were significant for affective flexibility. Cognitive flexibility didn’t contribute to affective flexibility beyond the predictors mentioned above. Anxiety exerted a negative effect on affective flexibility in a high anxious subgroup of preschoolers, but only when processing negative, relative to happy faces, supporting the Attentional Control Theory which predicts valence-related executive impairmentsinfo:eu-repo/semantics/publishedVersio

Fertility preservation in ovarian tumours

A considerable number of patients with a cancer diagnosis are of childbearing age and have not satisfied their desire for a family. Despite ovarian cancer (OC) usually occurring in older patients, 3%–14% are diagnosed at a fertile age with the overall 5-year survival rate being 91.2% in women ≤44 years of age when it is found at 1A–B stage. In this scenario, testing the safety and the efficacy of fertility sparing strategies in OC patients is very important overall in terms of quality of life. Unfortunately, the lack of randomised trials to validate conservative approaches does not guarantee the safety of fertility preservation strategies. However, evidence-based data from descriptive series suggest that in selected cases, the preservation of the uterus and at least one part of the ovary does not lead to a high risk of relapse. This conservative surgery helps to maintain organ function, giving patients of childbearing age the possibility to preserve their fertility. We hereby analysed the main evidence from the international literature on this topic in order to highlight the selected criteria for conservative management of OC patients, including healthy BRCA mutations carriers

An improved method of supercharged transposed latissimus dorsi flap with the skin paddle for the management of a complicated lumbosacral defect

OBJECTIVE: Treatment of nonhealing wounds of lower back often poses a powerful challenge. We present one of the first report of treatment of a lumbosacral defect with a supercharged latissimus dorsi flap with the skin paddle. CASE REPORT: We report a case of a 59 yearold man with myeloma of the sacral spine who underwent radiotherapy and chemotherapy and subsequently, laminectomies and placement of hardware for ongoing paresis and spine instability. Then, he developed an open wound and osteomyelitis of the spine with culture positive tuberculous granulomas. After multiple surgical debridement, he presented to our service and was treated with a single stage debridement followed by the performance of a latissimus dorsi musculocutaneous flap based on paraspinal perforators and supercharged. RESULTS: This solution, allowed for augmentation of blood flow to the muscle with the inferior gluteal artery, provided coverage of the defect resistant to the pressure, and simplified post-operative management of the patient. CONCLUSIONS: Alternative treatment options, including free tissue transfer, posed difficulties in finding suitable recipient vessels near the defect, in inserting the flap so as to restore its original length without compromising blood flow, and in postoperative care of the patient. Treatment of a lumbosacral defect with a supercharged latissimus dorsi flap with the skin paddle may represent a milestone procedure for complicated lower spine wounds

Exploiting the network for securing personal devices

Personal devices (such as smartphones and laptops) often experience incoherent levels of security due to the different protection applications available on the various devices. This paper presents a novel approach that consists in offloading security applications from personal devices and relocating them inside the network; this will be achieved by enriching network devices with the appropriate computational capabilities to execute generic security applications. This approach is fostered by the Secured project, which will define the architecture, data and protocols needed to turn this vision into reality

Machine learning approach using MLP and SVM algorithms for the fault prediction of a centrifugal pump in the oil and gas industry

The demand for cost-effective, reliable and safe machinery operation requires accurate fault detection and classification to achieve an efficient maintenance strategy and increase performance. Furthermore, in strategic sectors such as the oil and gas industry, fault prediction plays a key role to extend component lifetime and reduce unplanned equipment thus preventing costly breakdowns and plant shutdowns. This paper presents the preliminary development of a simple and easy to implement machine learning (ML) model for early fault prediction of a centrifugal pump in the oil and gas industry. The data analysis is based on real-life historical data from process and equipment sensors mounted on the selected machinery. The raw sensor data, mainly from temperature, pressure and vibrations probes, are denoised, pre-processed and successively coded to train the model. To validate the learning capabilities of the ML model, two different algorithms-the Support Vector Machine (SVM) and the Multilayer Perceptron (MLP)-are implemented in KNIME platform. Based on these algorithms, potential faults are successfully recognized and classified ensuring good prediction accuracy. Indeed, results from this preliminary work show that the model allows us to properly detect the trends of system deviations from normal operation behavior and generate fault prediction alerts as a maintenance decision support system for operatives, aiming at avoiding possible incoming failures

Self-contained neuromusculoskeletal arm prostheses

We report the use of a bone-anchored, self-contained robotic arm with both sensory and motor components over 3 to 7 years in four patients after transhumeral amputation. The implant allowed for bidirectional communication between a prosthetic hand and electrodes implanted in the nerves and muscles of the upper arm and was anchored to the humerus through osseointegration, the process in which bone cells attach to an artificial surface without formation of fibrous tissue. Use of the device did not require formal training and depended on the intuitive intent of the user to activate movement and sensory feedback from the prosthesis. Daily use resulted in increasing sensory acuity and effectiveness in work and other activities of daily life

Detour-impact index method and traffic gathering algorithm for assessing alternative paths of disrupted roads

Infrastructure plays a key role in society. Recent collapses of bridges have underlined their importance for road functionality, causing disruptions to commuters and emergency vehicles. Major issues arise on rural roads, where the lack of redundancy leads to the isolation of entire communities. Actual approaches to assess the resilience of countryside roads rely on the availability of specific datasets, limiting their practical application; this issue is typically related to traffic data. This research aims to propose innovative algorithms to assess the road network’s vulnerability in rural areas, including a novel traffic data collection process and its calibration. The aggregate metric is called Detour-Impact Index (DII) and compares user costs before and after a disruptive event. The method uses traditional network-impact metrics in combination with a new algorithm that allows us to gather quantitative traffic data starting from qualitative information. User travel time showed good agreement between the proposed procedure and traditional web-based methods. Furthermore, the paper provides user delay costs functions accounting for traffic composition, trip purposes, vehicle operative costs, nonlinear volume–capacity relation, and average daily traffic. A significant aspect is the adaptability of this framework, as it is designed to be coupled with existing approaches. The method is demonstrated on a case study in Tuscany (Italy).The first, third and sixth authors acknowledge that, this work was partly financed by FEDER funds through the Competitivity Factors Operational Programme - COMPETE and by national funds through FCT Foundation for Science and Technology within the scope of the project POCI-01-0145- FEDER-007633. This work was supported by the FCT Foundation for Science and Technology under Grant SFRH/ BD/145478/2019

Risk management for bridges: a case study of unforeseen failure mode

Risk management plays a crucial role in the stakeholders’ decision making because it is directly related to safety, serviceability and economy. There is now a growing concern about how to relocate known risks into an acceptance threshold: this implies the evaluation of several options obtained from hazard scenarios considering the related consequences. In parallel, practitioners usually rely on standard tools for risk assessment, and on structural codes to compute performances. Although this approach is currently widely implemented, this research shows that hazardous situations can arise in properly designed infrastructures, due to errors in management. This paper deals with such issue, also highlighting a gap in current codes that could contribute to losses caused by unforeseen failure modes. In this study, a preliminary FMEA assessment was performed to identify the failure modes that required a deeper quantitative analysis. In a second step, a quantitative analysis was implemented, using a modular methodology that combines reliability theory with a risk-based approach. The results evidenced that a wider analysis focused on the identification of vulnerable areas shall be considered in every stage of the asset management. Furthermore, the dynamic of this process is regulated by the established safety level concerning possible damages to people, production sites and commercial activities.This work was partly financed by FEDER funds through the Competitivity Factors Operational Programme - COMPETE and by national funds through FCT Foundation for Science and Technology within the scope of the project POCI01-0145-FEDER-007633. This work was supported by the FCT Foundation for Science and Technology under Grant SFRH/BD/145478/2019. This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 769255

Grip control and motor coordination with implanted and surface electrodes while grasping with an osseointegrated prosthetic hand

Background: Replacement of a lost limb by an artificial substitute is not yet ideal. Resolution and coordination of motor control approximating that of a biological limb could dramatically improve the functionality of prosthetic devices, and thus reduce the gap towards a suitable limb replacement. Methods: In this study, we investigated the control resolution and coordination exhibited by subjects with transhumeral amputation who were implanted with epimysial electrodes and an osseointegrated interface that provides bidirectional communication in addition to skeletal attachment (e-OPRA Implant System). We assessed control resolution and coordination in the context of routine and delicate grasping using the Pick and Lift and the Virtual Eggs Tests. Performance when utilizing implanted electrodes was compared with the standard-of-care technology for myoelectric prostheses, namely surface electrodes. Results: Results showed that implanted electrodes provide superior controllability over the prosthetic terminal device compared to conventional surface electrodes. Significant improvements were found in the control of the grip force and its reliability during object transfer. However, these improvements failed to increase motor coordination, and surprisingly decreased the temporal correlation between grip and load forces observed with surface electrodes. We found that despite being more functional and reliable, prosthetic control via implanted electrodes still depended highly on visual feedback. Conclusions: Our findings indicate that incidental sensory feedback (visual, auditory, and osseoperceptive in this case) is insufficient for restoring natural grasp behavior in amputees, and support the idea that supplemental tactile sensory feedback is needed to learn and maintain the motor tasks internal model, which could ultimately restore natural grasp behavior in subjects using prosthetic hands

An improved method of supercharged transposed latissimus dorsi flap with the skin paddle for the management of a complicated lumbosacral defect

OBJECTIVE: Treatment of non-healing wounds of lower back often poses a powerful challenge. We present one of the first report of treatment of a lumbosacral defect with a supercharged latissimus dorsi flap with the skin paddle. CASE REPORT: We report a case of a 59 year-old man with myeloma of the sacral spine who underwent radiotherapy and chemotherapy and subsequently, laminectomies and placement of hardware for ongoing paresis and spine instability. Then, he developed an open wound and osteomyelitis of the spine with culture positive tuberculous granulomas. After multiple surgical debridement, he presented to our service and was treated with a single stage debridement followed by the performance of a latissimus dorsi musculocutaneous flap based on paraspinal perforators and supercharged. RESULTS: This solution, allowed for augmentation of blood flow to the muscle with the inferior gluteal artery, provided coverage of the defect resistant to the pressure, and simplified post-operative management of the patient. CONCLUSIONS: Alternative treatment options, including free tissue transfer, posed difficulties in finding suitable recipient vessels near the defect, in inserting the flap so as to restore its original length without compromising blood flow, and in postoperative care of the patient. Treatment of a lumbosacral defect with a supercharged latissimus dorsi flap with the skin paddle may represent a milestone procedure for complicated lower spine wounds