Modeling Focused Ultrasound Exposure for the Optimal Control of Thermal Dose Distribution

Preclinical studies indicate that focused ultrasound at exposure conditions close to the threshold for thermal damage can increase drug delivery at the focal region. Although these results are promising, the optimal control of temperature still remains a challenge. To address this issue, computer-simulated ultrasound treatments have been performed. When the treatments are delivered without taking into account the cooling effect exerted by the blood flow, the resulting thermal dose is highly variable with regions of thermal damage, regions of underdosage close to the vessels, and areas in between these two extremes. When the power deposition is adjusted so that the peak thermal dose remains close to the threshold for thermal damage, the thermal dose is more uniformly distributed but under-dosage is still visible around the thermally significant vessels. The results of these simulations suggest that, for focused ultrasound, as for other delivery methods, the only way to control temperature is to adjust the average energy deposition to compensate for the presence of thermally significant vessels in the target area. By doing this, we have shown that it is possible to reduce the temperature heterogeneity observed in focused ultrasound thermal treatments

Presencia de dos especies de garrapatas (Acari: Ixodidae) con importancia médica en la ciudad de Buenos Aires

SINFil: Cicuttin, Gabriel L.. Provincia de Buenos Aires. Ministerio de Salud. Instituto de Zoonosis Luis Pasteur; Argentina;Fil: Sassaroli, Juan C.. Provincia de Buenos Aires. Ministerio de Salud. Instituto de Zoonosis Luis Pasteur; Argentina;Fil: Ardiles, María I.. Provincia de Buenos Aires. Ministerio de Salud. Instituto de Zoonosis Luis Pasteur; Argentina;Fil: Zotter, Ana C.. Provincia de Buenos Aires. Ministerio de Salud. Instituto de Zoonosis Luis Pasteur; Argentina;Fil: Guglielmone, Alberto Alejandro. Instituto Nacional de Tecnología Agropecuaria. Centro Reguional Córdoba. Estación Experimental Regional Agropecuaria Rafaela; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina;Fil: Nava, Santiago. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Santa Fe. Estación Experimental Agropecuaria, Rafaela; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina

Desire thinking as a predictor of drinking status following treatment for alcohol use disorder: A prospective study

© 2019 Elsevier Ltd Research has indicated that craving is one of the strongest predictors of treatment outcome and relapse in Alcohol Use Disorders (AUD) but there is little consensus on the factors that may influence its activation and escalation. Research has also shown that desire thinking is an important cognitive process which may exacerbate craving in problem drinkers. The aim of present study was to explore, for the first time, the role of desire thinking in prospectively predicting relapse, craving and binge drinking in patients receiving treatment for AUD. One hundred and thirty-five patients admitted to two rehabilitation centres and two outpatient services for addiction and mental health problems were administered baseline, treatment completion and three months follow-up measures of anxiety and depression, AUD severity, binge drinking frequency, craving and desire thinking. Results indicated that the verbal perseveration component of desire thinking at treatment completion was the only significant predictor of relapse at follow-up over and above baseline AUD severity and binge drinking frequency. Furthermore, the imaginal prefiguration component of desire thinking and craving levels at treatment completion were found to predict craving levels at follow-up independently of AUD severity and binge drinking frequency at baseline. Finally, both the imaginal prefiguration and verbal perseveration components of desire thinking at treatment completion were found to be the only predictors of binge drinking frequency at follow-up independently of AUD severity and binge drinking frequency at baseline. Treatments for AUD should aim to reduce desire thinking in people to enhance clinical outcomes and reduce relapse risk

Production of photons by the parametric resonance in the dynamical Casimir effect

We calculate the number of photons produced by the parametric resonance in a cavity with vibrating walls. We consider the case that the frequency of vibrating wall is $n \omega_1 (n=1,2,3,...)$ which is a generalization of other works considering only $2 \omega_1$, where $\omega_1$ is the fundamental-mode frequency of the electromagnetic field in the cavity. For the calculation of time-evolution of quantum fields, we introduce a new method which is borrowed from the time-dependent perturbation theory of the usual quantum mechanics. This perturbation method makes it possible to calculate the photon number for any $n$ and to observe clearly the effect of the parametric resonance.Comment: 15 pages, RevTeX, no figure

Radiative Phase Transitions and Casmir Effect Instabilities

Molecular quantum electrodynamics leads to photon frequency shifts and thus to changes in condensed matter free energies often called the Casimir effect. Strong quantum electrodynamic coupling between radiation and molecular motions can lead to an instability beyond which one or more photon oscillators undergo a displacement phase transition. The phase boundary of the transition can be located by a Casimir free energy instability.Comment: ReVTeX4 format 1 *.eps figur

Interference phenomena in the photon production between two oscillating walls

We study the photon production in a 1D cavity whose left and right walls oscillate with the frequency $\Omega_{L}$ and $\Omega_{R}$, respectively. For $\Omega_{L} \neq \Omega_{R},$ the number of generated photons by the parametric resonance is the sum of the photon numbers produced when the left and the right wall oscillates separately. But for $\Omega_{L} = \Omega_{R}$, the interference term proportional to $\cos \phi$ is found additionally, where $\phi$ is the phase difference between two oscillations of the walls.Comment: 7 pages, RevTeX, no figures, a sign error correcte

Observability of the Bulk Casimir Effect: Can the Dynamical Casimir Effect be Relevant to Sonoluminescence?

The experimental observation of intense light emission by acoustically driven, periodically collapsing bubbles of air in water (sonoluminescence) has yet to receive an adequate explanation. One of the most intriguing ideas is that the conversion of acoustic energy into photons occurs quantum mechanically, through a dynamical version of the Casimir effect. We have argued elsewhere that in the adiabatic approximation, which should be reliable here, Casimir or zero-point energies cannot possibly be large enough to be relevant. (About 10 MeV of energy is released per collapse.) However, there are sufficient subtleties involved that others have come to opposite conclusions. In particular, it has been suggested that bulk energy, that is, simply the naive sum of ${1\over2}\hbar\omega$, which is proportional to the volume, could be relevant. We show that this cannot be the case, based on general principles as well as specific calculations. In the process we further illuminate some of the divergence difficulties that plague Casimir calculations, with an example relevant to the bag model of hadrons.Comment: 13 pages, REVTe

Casimir Energy for a Spherical Cavity in a Dielectric: Applications to Sonoluminescence

In the final few years of his life, Julian Schwinger proposed that the ``dynamical Casimir effect'' might provide the driving force behind the puzzling phenomenon of sonoluminescence. Motivated by that exciting suggestion, we have computed the static Casimir energy of a spherical cavity in an otherwise uniform material. As expected the result is divergent; yet a plausible finite answer is extracted, in the leading uniform asymptotic approximation. This result agrees with that found using zeta-function regularization. Numerically, we find far too small an energy to account for the large burst of photons seen in sonoluminescence. If the divergent result is retained, it is of the wrong sign to drive the effect. Dispersion does not resolve this contradiction. In the static approximation, the Fresnel drag term is zero; on the mother hand, electrostriction could be comparable to the Casimir term. It is argued that this adiabatic approximation to the dynamical Casimir effect should be quite accurate.Comment: 23 pages, no figures, REVTe

Trembling cavities in the canonical approach

We present a canonical formalism facilitating investigations of the dynamical Casimir effect by means of a response theory approach. We consider a massless scalar field confined inside of an arbitaray domain $G(t)$, which undergoes small displacements for a certain period of time. Under rather general conditions a formula for the number of created particles per mode is derived. The pertubative approach reveals the occurance of two generic processes contributing to the particle production: the squeezing of the vacuum by changing the shape and an acceleration effect due to motion af the boundaries. The method is applied to the configuration of moving mirror(s). Some properties as well as the relation to local Green function methods are discussed. PACS-numbers: 12.20; 42.50; 03.70.+k; 42.65.Vh Keywords: Dynamical Casimir effect; Moving mirrors; Cavity quantum field theory; Vibrating boundary

Theory of quantum radiation observed as sonoluminescence

Sonoluminescence is explained in terms of quantum radiation by moving interfaces between media of different polarizability. In a stationary dielectric the zero-point fluctuations of the electromagnetic field excite virtual two-photon states which become real under perturbation due to motion of the dielectric. The sonoluminescent bubble is modelled as an optically empty cavity in a homogeneous dielectric. The problem of the photon emission by a cavity of time-dependent radius is handled in a Hamiltonian formalism which is dealt with perturbatively up to first order in the velocity of the bubble surface over the speed of light. A parameter-dependence of the zero-order Hamiltonian in addition to the first-order perturbation calls for a new perturbative method combining standard perturbation theory with an adiabatic approximation. In this way the transition amplitude from the vacuum into a two-photon state is obtained, and expressions for the single-photon spectrum and the total energy radiated during one flash are given both in full and in the short-wavelengths approximation when the bubble is larger than the wavelengths of the emitted light. It is shown analytically that the spectral density has the same frequency-dependence as black-body radiation; this is purely an effect of correlated quantum fluctuations at zero temperature. The present theory clarifies a number of hitherto unsolved problems and suggests explanations for several more. Possible experiments that discriminate this from other theories of sonoluminescence are proposed.Comment: Latex file, 28 pages, postscript file with 3 figs. attache