Ozonation attenuates the steroidogenic disruptive effects of sediment free oil sands process water in the H295R cell line

There is concern regarding oil sands process water (OSPW) produced by the oil sands industry in Alberta, Canada. Little is known about the potential for OSPW, and naphthenic acids (NAs), which are the primary persistent and toxic constituents of OSPW, to affect endocrine systems. Although ozonation significantly reduces concentrations of NAs and OSPW toxicity, it was hypothesized that oxidation of OSPW might produce hydroxylated products with steroidogenic activity. Therefore, untreated and ozone treated OSPW were examined for effects on sex steroid production using the H295R Steroidogenesis Assay. Untreated OSPW significantly decreased testosterone (T) and increased 17 beta-estradiol (E2) concentrations at OSPW dilutions greater or equal to 10-fold. This effect was mainly due to decreased U metabolism. Analysis of CYP19A (aromatase) mRNA abundance and enzyme activity suggested that induction of this enzyme activity may have also contributed to these effects. Reduction of parent NA concentrations by 24% or 85% decreased the effect of OSPW on E2 production. Although T production remained significantly reduced in cells exposed to ozone treated OSPW, the effect was diminished. Aromatase mRNA abundance and enzyme activity were significantly greater in cells exposed to ozone treated OSPW. however the magnitude was less than in cells exposed to untreated OSPW. No change of U metabolism was observed in cells exposed to ozone treated OSPW, which may account for recovery of E2 levels. The results indicate that OSPW exposure can decrease E2 and T production, but zonation is an effective treatment to reduce NA concentrations in OSPW without increasing affects on steroidogenesis. (C) 2010 Elsevier Ltd. All rights reserved.Alberta Water Research Institute [C4288]; National Science and Engineering Research Council of Canada [326415-07]; Western Economic Diversification Canada [6578, 6807]; Canada Foundation for Infrastructur

Potential of the bioeconomy for transforming food systems

Se busca identificar, analizar y visibilizar el papel que puede desempeñar la bioeconomía en el fortalecimiento y la transformación de los sistemas alimentarios, particularmente en América Latina y el Caribe. Se analiza el concepto de la bioeconomía, sus impulsores, enfoques de desarrollo sostenible y aportes de la bioeconomía a los ODS de la Agenda 2030; además se hace énfasis en las potencialidades de la bioeconomía; finalmente se analizan los retos, desafíos y la agenda pendiente en materia bioeconómica.It seeks to identify, analyze and make visible the role that the bioeconomy can play in strengthening and transforming food systems, particularly in Latin America and the Caribbean. The concept of the bioeconomy, its drivers, sustainable development approaches and contributions of the bioeconomy to the SDGs of the 2030 Agenda are analyzed; In addition, emphasis is placed on the potentialities of the bioeconomy; Finally, the challenges, challenges and the pending agenda in bioeconomic matters are analyzed.Busca identificar, analisar e tornar visível o papel que a bioeconomia pode desempenhar no fortalecimento e transformação dos sistemas alimentares, particularmente na América Latina e no Caribe. Analisa-se o conceito de bioeconomia, seus direcionadores, abordagens de desenvolvimento sustentável e contribuições da bioeconomia para os ODS da Agenda 2030; Além disso, a ênfase é colocada nas potencialidades da bioeconomia; Por fim, são analisados ​​os desafios, desafios e a agenda pendente em questões bioeconômicas

Les Documents de travail du colloque = The forum papers /

Comprend une bibliogr. annotéeNotes (part. bibliogr.) au bas des p

L'accès et la participation à l'enseignement postsecondaire au Canada = Accessibility to and Participation in the Post-secondary Education System in Canada /

Titre de la couvNotes bibliogr. au bas des p

Notes pour une allocution de M. Maurice Strong lors du Colloque national sur l'enseignement postsecondaire, Saskatoon (Saskatchewan), Canada, le 25 octobre 1987

Titre de la cou