Detection Limit for Optically Sensing Specific Protein Interactions in Free-solution

Optical molecular sensing techniques are often limited by the refractive index change associated with the probed interactions. In this work, we present a closed form analytical model to estimate the magnitude of optical refractive index change arising from protein-protein interactions. The model, based on the Maxwell Garnett effective medium theory and first order chemical kinetics serves as a general framework for estimating the detection limits of optical sensing of molecular interactions. The model is applicable to situations where one interacting species is immobilized to a surface, as commonly done, or to emerging techniques such as Back-Scattering Interferometry (BSI) where both interacting species are un-tethered. Our findings from this model point to the strong role of as yet unidentified factors in the origin of the BSI signal resulting in significant deviation from linear optical response.Comment: 7 Page Manuscript + 14 Page Supplementary Informatio

Data Classification for Achieving Security in Cloud Computing

AbstractData is the valuable asset and of great concerns when moving towards the cloud. Data privacy and security is the active area of research and experimentations in cloud computing. Data leakage and privacy protection is becoming crucial for many organizations moving on to cloud. Data can be of various types and degree of protection required for all the data is also varies. Here we are proposing a classification technique that defines various parameters. Parameters are defined based on various dimensions. Data security can be provided based on the level and the required protection. Corresponding security provisions at the storage can be applied based on data set classified as per the dimensions. The efficiency of the proposed classification scheme is analyzed with the sample dataset collected

MULTIPLE SCLEROSIS-AYURVEDIC MANAGEMENT AND PREVENTIVE ASPECTS

Multiple Sclerosis (MS) is a chronic progressive disease with a variety of cognitive, motor and sensory deficits. It is characterised by demyelination of axons of the brain and spinal cord where the patient presents with the complaints of blurred or double vision, lack of coordination, loss of balance, numbness and tremors throughout the body or extremities with weakness, muscle spasms etc. In Ayurveda, Multiple Sclerosis can be correlated to Snayusada or the aggravation of Vata in Snayu. Modern treatments like immunosuppressant, corticosteroids, stem cell therapy are highly expensive when compared to Ayurvedic management. The scope of Ayurvedic Management and preventive aspects mainly concentrates on improving the quality of life and decrease dependency of patients. The objective of this review is to evaluate the clinical utility of the Ayurvedic medicines for Multiple Sclerosis. Clinical trials by Ayurvedic experts suggest that Ayurvedic treatment processes and preventive measures (Life style management and recommended diet) may reduce the risk of Multiple Sclerosis. Here I briefly explain the current literature of Multiple Sclerosis, modern and Ayurvedic views, Ayurvedic medicines usually given in Multiple Sclerosis cases with a focus on designing prevention and treatment protocol

An Overview Study on Awareness of Global Warming Among the Graduate Teacher Trainees

Nowadays global warming is considered as a burning problem and it is being a challenge to the entire world and its scientific society. Global warming is a worldwide environmental problem by which there is an abnormal increase to the level of temperature, particularly in a natural environment. Global warming is not only affecting the nature, but it affects the life and homes of millions of people. The changes of global warming is visible from the highest mountains to deep in the oceans and it extinguished different parts of the earth and it's also creates rich bio-diversity. To identify the level of awareness global warming and to enhance the same among future secondary school teachers, the Authors decided to conduct the present research study of awareness on global warming among graduate Teacher trainees of college of education. Further, the study may also help the student teachers of secondary schools to create awareness on global warming among students studying in secondary schools in future. Keywords: global warming, climatic Change, green house effect, environmental refugees, and 3R

SYNTHESIS AND EVALUATION OF ANTI-INFLAMMATORY AND ANTIBACTERIAL ACTIVITIES OF SOME 1, 2-BENZISOXAZOLE DERIVATIVES

Objective: A series of 1, 2-Benzisoxazole derivatives were synthesized and characterized by various analytical techniques like Melting point, Rf, FTIR, and NMR spectra.Methods: Structures of the compounds were elucidated and evaluated for anti-inflammatory activity by HRBC membrane stabilization method, antibacterial activity against Escherichia coli and Staphylococcus aureus by cup plate method.Results: The compounds 4a and 4e showed good anti-inflammatory activity compared with standard drug Diclofenac sodium and compounds 4b and 4d showed good antibacterial activity on compared with standard drug Gentamycin.Conclusion: These compounds may serve as future leads for anti-inflammatory and antibacterial drug discovery

Effect of Information Processing Approach in Enhancing Achievement in Chemistry at Higher Secondary level

Teaching is considered both an art and a science.  Successful and effective teaching requires two basic things.  The teacher should be competent to teach the subject allotted to him/her at the same time he/she should follow new techniques of teaching to make the learning fruitful and interesting. The traditional methods of technology have failed to generate the required behavioural outcomes, abilities and skills needed to facilitate the learning of curricular subjects. Knowledge of the recent development will help the teacher in making his/her teaching more effective and increase his/her efficiency for class room functioning.  Such a background will solve classroom problems, enable him/her to organize teaching activities and select instructional design and teaching models and innovative techniques appropriate for his/her classroom situation.  All innovative strategies and techniques, it should give enough scope for developing learning environment among students. Processing information is the main concern of any teacher.  If the information is processed effectively, learning techniques should be right and they should meet the individual needs of all learners and so the teachers should adopt a model of teaching which would be flexible and interactive.  The information processing approach technique in teaching chemistry was effective in Higher Secondary School classes. Implementation of this approach provided a great opportunity, to students to take an active part in the process of learning.  Through the information processing approach the achievement of student was enhanced to a great extent.Keywords: Information, Processing, Model, Chemistry

In Vitro Antioxidant and Cytotoxic Analysis of Boerhaavia diffusa Linn.

The present study was carried out to evaluate the antioxidant and cytotoxic activity of unexploited plant, Boerhaavia diffusa indigenous to India. Different concentrations of the ethanolic whole-plant extracts (1000, 500, 250, 125, 50, 25, 12.5 μg/ml) were subjected to 1,1-diphenyl -2-picryl hydrazyl (DPPH) radical scavenging, reducing power activity and cytotoxic study against vero cell lines. The maximum DPPH radical scavenging potential was found to be 93% at 1000 μg/ml with IC50 (Inhibitory Concentration) value being 49.95±1.15 μg/ml. The maximum reducing power of the extract at 700nm was found to be 0.997±0.081 at 1000 μg/ml. The inhibition percentage with regard to cytotoxicity was found to be 89 % at 1000 μg/ml with IC50 value of 50+0.03 μg/ml

A study of efficiacy of chemical and surgical management of fissure in ano

AIMS OF THE STUDY: 1) To find the age and the sex incidence of fissure in ano. 2) To study the various modes of clinical presentation of fissure in ano and the various types of fissure in ano. 3) To evaluate the effectiveness of topical 0.2% Glyceryl trinitrate in the symptomatic relief and healing of anal fissures. 4) To compare the effectiveness of lateral anal sphincterotomy and chemical sphincterotomy in fissure in ano. 5) To establish the role of glyceryl trinitrate as the first line treatment for both acte and chronic fissures. MATERIALS AND METHODS: SETTING: Study was a prospective comparative study done in Government Kilpauk Medical College Hospital from January 2015 to June 2015. The Study Population was divided into two groups.The Patients were of age group 18 to 60 years. 100 cases were studied. STUDY POPULATION: The study population was divided into two groups of 50 patients each. One study group was treated with topical application of 0.2% Glyceryl trinitrate along with sitz bath. Oral antibiotics such as Cap Amoxycillin 500 mg BD and Tab. Metronidazole 400 mg TDS for the first 1 week along with topical 0.2% Glyceryl trinitrate application about the size of a pea, over the anal verge thrice daily for a period of 4 weeks and observed. Another study group was admitted in the ward and taken up for lateral anal sphincterotomy under antibiotic over and a preoperative plain water enema. The results were analyzed and published. RESULT: In the end of the study we found that the surgical procedure for fissure in ano has better cure rate than medical management. CONCLUSION: The fissure in ano has a slight female preponderance.The sex incidence ratio is 1.2:1 in favour of females. • The fissure is ano occurs more commonly in 3rd decade (ie) young adults. • The most common clinical presentation of fissure in ano is painful defecation,which occurs is 90 out of 100 patients studied. • The incidence of both acute and chronic fissures were almost the same. • The most common location of fissure is posterior midline.86 out of 100 patients showed fissure in the posterior midline .Only 14 patients had anterior midline fissure . Of these all were females. • Surgery in the form of open or closed lateral anal sphincterotomy forms the definitive treatment , healing fissure in almost all patients with very few postoperative complications. • Chemical sphincterotomy (ie) topical application of 0.2% Glyceryltrinitrate healed 33 out of 50 patients (i.e) 64% efficacy rate. • The most promment side effect of topical application of 0.2% Glyceryltrinitrate, (ie) headache was present in 24% and was tolerable and relieved by simple analgesics. • Hence topical application of 0.2% Glyceryltrinitrate can be established as the first line treatment of acute and chronic and fissures