Physical and digital phantoms for validating tractography and assessing artifacts

Fiber tractography is widely used to non-invasively map white-matter bundles in vivo using diffusion-weighted magnetic resonance imaging (dMRI). As it is the case for all scientific methods, proper validation is a key prerequisite for the successful application of fiber tractography, be it in the area of basic neuroscience or in a clinical setting. It is well-known that the indirect estimation of the fiber tracts from the local diffusion signal is highly ambiguous and extremely challenging. Furthermore, the validation of fiber tractography methods is hampered by the lack of a real ground truth, which is caused by the extremely complex brain microstructure that is not directly observable non-invasively and that is the basis of the huge network of long-range fiber connections in the brain that are the actual target of fiber tractography methods. As a substitute for in vivo data with a real ground truth that could be used for validation, a widely and successfully employed approach is the use of synthetic phantoms. In this work, we are providing an overview of the state-of-the-art in the area of physical and digital phantoms, answering the following guiding questions: “What are dMRI phantoms and what are they good for?”, “What would the ideal phantom for validation fiber tractography look like?” and “What phantoms, phantom datasets and tools used for their creation are available to the research community?”. We will further discuss the limitations and opportunities that come with the use of dMRI phantoms, and what future direction this field of research might take

How Can International Institutions Be Improved to Ensure Accountability and Justice for Violations That Occur in Humanitarian and Counter-Terrorism Operations?

The thesis purports to assess the United Nations Security Council (UNSC) in maintaining international peace and security and the International Criminal Court (ICC) in prosecuting individuals who have committed severe violations of international humanitarian law (IHL) and international law, during humanitarian and counter-terrorism operations. The thesis endeavours to highlight the failures of both institutions, firstly, the UNSC being unable to fulfil its institutional mandate, which is mainly attributed to the abuse of veto privileges granted to the five permanent members (P5). This has effectively allowed individuals from the militaries of the P5 and their allies elude criminal liability, promoting a culture of impunity. The UNSC’s failure to prevent P5 members use of unauthorised military force in pursuing counter-terrorism operations and interpose expeditiously in humanitarian crises, have also contributed to the erosion of the institutions’ legitimacy, which is further perpetuated by the USA’s continued ‘War on Terror’ doctrine after the 9/11 terrorist attacks. Secondly, the ICC’s inability to prosecute individuals for crimes under the Rome Statute will also be highlighted as the principle of complementarity and the court’s inability to enforce arrest warrants are significant factors contributing to the institutions inability to administer international criminal justice. The thesis draws upon practical examples to substantiate the failures of both institutions by referring to the conflicts in: Afghanistan, Iraq, Palestine, Syria and Libya. Before concluding the UNSC and the ICC have become futile, the thesis will then make recommendations for reform and propose a novel solution to restore legitimacy back to both institutions

Phenotypes of Alpha 1 Antitrypsin in Karachi, Pakistan

Objective: To determine serum level of the protease inhibitor, to identify phenotypes and determine their frequencies. Study Design: A prospective study. Setting: PMRC Research Centre, JPMC and the Aga Khan University Hospital Karachi. Subjects: Healthy aduIts without history ol peptic ulcer disease and a normal endoscopy. Methodology: Quantitive measurement of serum alpha 1 AT was carried out by radial immunodiffusion. phenotyping by iso-electric focusing and confirmation of phenotypes by immunofixation and DNA analysis technique. Results:Serum alpha I AT was low in 13.4% of the subjects. Ni MM phenotype predominated followed by SZ SS, MZ and ZZ. DNA diagnosis accurately resolved the phenotypes as S and Z. Conclusion: Frequency by phenotype associated with total and intermediate deficiency is less in the populatio

Semiconductor Halogenation in Molecular Highly-Oriented Layered p–n (n–p) Junctions

Organic p–n junctions attract widespread interest in the field of molecular electronics because of their unique optoelectronic singularities. Importantly, the molecular donor/acceptor character is strongly correlated to the degree of substitution, e.g., the introduction of electron-withdrawing groups. Herein, by gradually increasing the degree of peripheral fluorination on planar, D4h−symmetric iron(II) phthalocyanato (FePc) complexes, the energy level alignment and molecular order is defined in a metal-supported bilayered Pc-based junction using photoemission orbital tomography. This non-destructive method selectively allows identifying molecular levels of the hetero-architectures. It demonstrates that, while the symmetric fluorination of FePc does not disrupt the long-range order and degree of metal-to-molecule charge transfer in the first molecular layer, it strongly impacts the energy alignment in both the interface and topmost layer in the bilayered structures. The p–n junction formed in the bilayer of perhydrogenated FePc and perfluorinated FeF16Pc may serve as an ideal model for understanding the basic charge-transport phenomena at the metal-supported organic–organic interfaces, with possible application in photovoltaic devices

Riparian zone as a variable source area for the estimation of evapotranspiration through the analysis of daily fluctuations in streamflow

Evapotranspiration is a critical component of the water balance of a catchment, and riparian zones play a crucial role in the hydrological process. However, the influence of riparian zones on evapotranspiration, especially at a catchment scale, needs more investigation. Since evapotranspiration is negligible at night, the difference in recharge between day and night generates diurnal fluctuations in streamflows. A new method is developed to estimate riparian evapotranspiration by analysing the streamflow response to diurnal evapotranspiration. The potential evapotranspiration (PET) calculated by FAO-56 is used as a true reference for validation. The estimated evapotranspiration shows acceptable goodness of fit with the hourly PET calculated from FAO 56. However, the new approach estimates average evapotranspiration across the entire riparian area than a point observation and provides a better understanding of the impact of the riparian zone on streamflow patterns

Safety of medical device users : a study of physiotherapists' practices, procedures and risk perception

Aims: To study practices and procedures with respect to electrotherapy in physiotherapy departments and to study physiotherapists’ perception of health risk, health consequences and protection of health from different risks including electromagnetic field emissions from electrotherapy devices. Methods: This cross-sectional study was conducted in three phases from June 2002 to December 2003. The first phase was an audit of the practices and procedures regarding electrotherapy in National Health Service physiotherapy departments (N = 46 including 7 departments in pilot study) located in 12 counties in the southeast and southwest of England including Greater London. The second phase comprised one observational visit to each of the same physiotherapy departments to characterise their occupational environment. The third phase was a questionnaire survey of 584 physiotherapists working in these departments. Variables concerned perception of health risk, health consequences and protection of health associated with different risk factors. Results: In the first two phases, the recruitment rate of the departments was 80.7% (46 out of 57) and response rate of those recruited was 100% (n=46). The response rate for the last phase of the study was 66.8% (390 out of 584). Results of the practices and procedures audit show that ultrasound was the most common form of electrotherapy while microwave diathermy was neither available nor used in these departments. Pulsed shortwave diathermy was used 4-5 days per week while continuous shortwave diathermy was used rarely. Electrotherapy was provided to up to 50% of patients per week in the departments. The observational visits to the departments revealed that there were metallic objects within close proximity of diathermy equipment and wooden treatment couches for treatment with PSWD and CSWD were rare. The risk perception survey showed that physiotherapists generally perceived a moderate health risk and health consequences (harm) from exposure to EMF emissions from electrotherapy devices. Protection from EMFs in physiotherapy departments was generally perceived as ‘usually’ possible. Conclusions: Physiotherapy departments report safe electrotherapy practices. Use of diathermy devices that use RF EMFs is declining. The key predictors of physiotherapists’ perception of health risk were perception of health consequences and vice versa. Gender was a significant predictor of the perception of health risks and health consequences. The main predictor of perception of protection against risk was the knowledge of environmental and health issues. Latent dimensions of perceptions of health risk, health consequences and protection from risk were identified and confirmed and their predictors were determined.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

TMSA: participatory sensing based on mobile phones in urban space

A design for a novel mobile sensing system, called Temperature Measurement System Architecture (TMSA), that uses people as mobile sensing nodes in a network to capture spatiotemporal properties of pedestrians in urban environments is presented in this paper. In this dynamic, microservices approach, real-time data and an open-source IoT platform are combined to provide weather conditions based on information generated by a fleet of mobile sensing platforms. TMSA also offers several advantages over traditional methods using participatory sensing or more recently crowd-sourced data from mobile devices, as it provides a framework in which citizens can bring to light data relevant to urban planning services or learn human behaviour patterns, aiming to change users’ attitudes or behaviors through social influence. In this paper, we motivate the need for and demonstrate the potential of such a sensing paradigm, which supports a host of new research and application developments, and illustrate this with a practical urban sensing example.This work has been supported by FCT - Fundacao para a Ciencia e Tecnologia within the R&D Units Project Scope: UIDB/00319/2020. It has also been supported by na tional funds through FCT – Fundação para a Ciência e Tecnologia through project ˆ UIDB/04728/2020

ERYTHROCYTE INDICES IN NORMAL ONE-HUMPED CAMEL: EFFECTS OF SEX, AGE IN MALES AND LACTATION AND/OR PREGNANCY IN FEMALES

Seven erythrocyte indices were studied in 56 clinically healthy one-humped camels in summer. Twenty-eight of these were males divided into four groups of seven each: upto 4 years old, 5 to 6 years, 6 to 7 years, and above 7 years. The remaining 28 comprised heifers, not-pregnant dry, pregnant-dry, and not-pregnant lactating females with seven animals in each group. Irrespective of sex and age, these camels showed the following overall averages ± standard error: Analysis of variance revealed that sex affected none of the seven parameters studied and so was lactation and/or pregnancy. The values of PCV and Hb decreased as the age progressed