Evaluating urban housing development patterns in developing countries: Case study of Worn-out Urban Fabrics in Iran

The restoration of Worn-out Urban Fabrics (WoUFs), i.e., the disfiguration of fabric components of the city from their main shape, and the implementation of the urban housing development plan have always been pivotal activities for designing livable cities – especially in developing countries. Prior research, however, did not identify an appropriate model of sustainable housing development for the recovery of WoUFs. To fill this gap, housing development patterns – i.e., supportive housing, Mehr housing, rental, and social housing – aimed at restoring the WoUF of the Hemmatabad district in Isfahan city (Iran) were studied. Expert opinions, on the criteria affecting the selection of housing development patterns, from 40 professionals in urban management and urban development models were collected and then analyzed by the Analytic Hierarchical Process and VIKOR method. It resulted that, in order to revive the WoUF of Hemmatabad, social housing is the more desirable pattern of housing development (Qi = 1) compared to supportive housing (Qi = 0.911), Mehr housing (Qi = 0.117) and rental housing (Qi = 0.004). Results help governments of developing countries in directing their effort in the decision of which housing development pattern for WoUFs to implement

Assessing the Barriers and Risks to Private Sector Participation in Infrastructure Construction Projects in Developing Countries of Middle East

In developing countries, governments are often unable to implement urban infrastructure construction projects (UICPs) on their own, mainly due to budget and financial resource limitations. The participation of the private sector, through public–private partnerships (PPPs), has been considered as an alternative effective method for increasing the efficiency and productivity of urban infrastructure development. However, in many developing countries such as those situated in the Middle East, attracting private sector investments for UICPs uncovers profound challenges that have not ever been comprehensively accounted for and prioritized. To fill this knowledge gap, this study seeks to determine and prioritize the major barriers and risks faced by governments and urban managers in attracting private sector investments through the PPP schemes launched by developing countries in the Middle East. Based on a Delphi study conducted in Iran as an example, the opinions of 60 UICPs experts in both the public and private sectors were collected and analyzed. Results show that technical and organizational barriers and risks were perceived as the most important to private sector participation, followed by economic and financial barriers and risks, and then political and legal barriers and risk

Long-Term Estrogen Receptor Beta Agonist Treatment Modifies the Hippocampal Transcriptome in Middle-Aged Ovariectomized Rats.

Estradiol (E2) robustly activates transcription of a broad array of genes in the hippocampal formation of middle-aged ovariectomized rats via estrogen receptors (ERalpha, ERbeta, and G protein-coupled ER). Selective ERbeta agonists also influence hippocampal functions, although their downstream molecular targets and mechanisms are not known. In this study, we explored the effects of long-term treatment with ERbeta agonist diarylpropionitrile (DPN, 0.05 mg/kg/day, sc.) on the hippocampal transcriptome in ovariectomized, middle-aged (13 month) rats. Isolated hippocampal formations were analyzed by Affymetrix oligonucleotide microarray and quantitative real-time PCR. Four hundred ninety-seven genes fulfilled the absolute fold change higher than 2 (FC > 2) selection criterion. Among them 370 genes were activated. Pathway analysis identified terms including glutamatergic and cholinergic synapse, RNA transport, endocytosis, thyroid hormone signaling, RNA degradation, retrograde endocannabinoid signaling, and mRNA surveillance. PCR studies showed transcriptional regulation of 58 genes encoding growth factors (Igf2, Igfb2, Igf1r, Fgf1, Mdk, Ntf3, Bdnf), transcription factors (Otx2, Msx1), potassium channels (Kcne2), neuropeptides (Cck, Pdyn), peptide receptors (Crhr2, Oprm1, Gnrhr, Galr2, Sstr1, Sstr3), neurotransmitter receptors (Htr1a, Htr2c, Htr2a, Gria2, Gria3, Grm5, Gabra1, Chrm5, Adrb1), and vesicular neurotransmitter transporters (Slc32a1, Slc17a7). Protein-protein interaction analysis revealed networking of clusters associated with the regulation of growth/troph factor signaling, transcription, translation, neurotransmitter and neurohormone signaling mechanisms and potassium channels. Collectively, the results reveal the contribution of ERbeta-mediated processes to the regulation of transcription, translation, neurogenesis, neuromodulation, and neuroprotection in the hippocampal formation of ovariectomized, middle-aged rats and elucidate regulatory channels responsible for DPN-altered functional patterns. These findings support the notion that selective activation of ERbeta may be a viable approach for treating the neural symptoms of E2 deficiency in menopause

Barriers to Attracting Private Sector Investment in Public Road Infrastructure Projects in the Developing Country of Iran

Abstract Private sector investment, the mainstream financing method for procuring public road transport development projects, has encountered several profound difficulties and risks during execution, particularly in developing countries. However, there needs to be more extensive investigations on the major barriers facing road transport infrastructure projects in these countries. In this vein, the present study aims to identify and assess the perceived barriers inhibiting private sector investment in delivering public road transport infrastructure projects in the developing country of Iran. The research method adopted is based on a descriptive survey with a three-round Delphi technique with 35 experts from both the private and public sector in Iran. According to the research study results, four main groups of legal and organizational, political, economic, and operational barriers have been found to significantly impact the attraction of private sector investment in such projects. The three most significant obstacles for public road transport infrastructure projects in developing countries include: (i) a lack of financial and investment safety; (ii) a lack of proficient managers and policies of public organizations in order to facilitate the process of privatization; and (iii) corruption in the privatization process. The survey findings can help the government and policymakers to eliminate or alleviate the potential barriers towards private sector participation in future public road infrastructure projects, particularly in those developing countries such as Iran

Perceptions of Safety Climate in Construction Projects between Workers and Managers/Supervisors in the Developing Country of Iran

What are the different perceptions on safety climate (SC) by workers and managers/supervisors engaged in the construction industry of developing countries? Reconciling these two differing views is pivotal for mitigating and avoiding both the injured and fatal accidents in the construction industry, especially in those developing countries where safety conditions are poor and unpredictable, and safety measures are inadequate in most cases. To answer this research question, the collective perceptions of 118 construction workers and 123 managers/supervisors on the SC in construction projects in Iran were gleaned and investigated. In particular, these perceptions were initially collected by two different empirical surveys validated by a sample of university professors and construction managers and then analyzed through the Kaiser-Meyer-Olkin (KMO) test and Bartlett’s test of sphericity under factor analysis, together with a one-sample t-test. Results indicated that “workers’ attitudes and perceptions”, “safety knowledge and training”, “working relationships and roles of colleagues”, and “workers’ risk perceptions” are important categories of SC factors perceived by construction workers, whereas “safety rules and management practices” is the essential category of SC factors discerned by managers/supervisors. The difference in perceptions between workers and managers/supervisors is considered to be beneficial for an overall understanding of SC in general and for developing countries in particular. Moreover, a series of effective suggestions for improving SC in the construction industry of developing countries are provided with reference to each category. The views of SC factors are reinforced as a social process combining the synergies of workers and managers/supervisors, as well as proper safety training to be pushed forward as an essential activity that should be incorporated in human resources development of construction organizations so as to improve the existing level of SC, leading to fewer accidents at the industry level

Epigenetics in Prostate Cancer

Prostate cancer (PC) is the most commonly diagnosed nonskin malignancy and the second most common cause of cancer death among men in the United States. Epigenetics is the study of heritable changes in gene expression caused by mechanisms other than changes in the underlying DNA sequences. Two common epigenetic mechanisms, DNA methylation and histone modification, have demonstrated critical roles in prostate cancer growth and metastasis. DNA hypermethylation of cytosine-guanine (CpG) rich sequence islands within gene promoter regions is widespread during neoplastic transformation of prostate cells, suggesting that treatment-induced restoration of a “normal” epigenome could be clinically beneficial. Histone modification leads to altered tumor gene function by changing chromosome structure and the level of gene transcription. The reversibility of epigenetic aberrations and restoration of tumor suppression gene function have made them attractive targets for prostate cancer treatment with modulators that demethylate DNA and inhibit histone deacetylases

A Global Survey of Infection Control and Mitigation Measures for Combating the Transmission of COVID-19 Pandemic in Buildings Under Facilities Management Services

Facilities management along with health care are two important aspects in controlling the spread of infectious diseases with regard to controlling the outbreak of global COVID-19 pandemic. Hence, with the increasing outbreak of COVID-19 pandemic, the importance of examining the relationship between the built environment and the outbreak of infectious diseases has become more significant. The aim of the research described in this article is to develop effective infection control and mitigation measures to prevent the transmission of COVID-19 pandemic in the built environment. This study seeks to answer the question of how the facilities management industry can help reduce the transmission of coronavirus. For this purpose, an online survey questionnaire was distributed internationally from 8 April to 25 July, 2020 to collect data from various key stakeholders. The collected data were analyzed by SPSS software. Various methods for the prevention and control of infectious diseases transmission are evaluated through this questionnaire-based survey with regard to their effectiveness for the healthy and safe built environment. These methods were categorized into three groups, including training protocols, operation and maintenance, and design and construction. The results show that all suggested methods have a positive effect on all types of buildings. These methods have an equal effect on low-risk buildings, while for high and very high-risk buildings, training protocols and design and construction measures have the greatest impact. In addition, training protocols and the measures in operation and maintenance will have the greatest effect on medium-risk buildings. The results can help in more rational decision making in relation to controlling the outbreak of COVID-19 pandemic in all types of buildings

Managerial opportunities in application of business intelligence in construction companies

In construction projects, managers make multiple decisions every day. Most of these decisions are relatively unimportant; some of them are critical and could lead to the success or failure of a construction project. To ensure construction companies make effective managerial decisions, decision making requires performing an initial technical and economic analysis, comparing different decision-making solutions, using a planning system, and ensuring project implementation based on the provided plans. Therefore, the use of powerful systems such as business intelligence (BI), which play a central role in management and decision-making, is essential in project-based companies. The current study aims to determine and evaluate the main managerial opportunities in the application of BI in project-based construction companies using a descriptive survey approach. An empirical research questionnaire consisting of 60 factors and 7 categories was adopted. The questionnaire, after confirming its validity and reliability, was distributed to 100 experts engaged in 5 active project-based construction companies who were familiar with BI topics. To analyse the data, a one-sample t-test and the Friedman test were performed using the SPSS software. The findings indicated that the importance of the identified opportunities for the use of BI in project-based construction companies is above average and that, in the case of using BI in such companies, these opportunities can be used to improve project performance. The results of the current study can help managers and other stakeholders as an effective decision-making tool to better implement BI in project-based companies