การศึกษาน้ำมันหอมระเหยจากขิง ไพล และขมิ้นอ้อยในแง่การเป็นสารเพิ่มการดูดซึมผ่านผิวหนัง

Thailand Research Fund (TRF

Investigation of enhancing effect of glucam® P-20 on the in vitro skin permeation of diclofenac sodium microemulsions

The aim of this work was to investigate the potential of Glucam® P-20 as a skin penetration enhancer for diclofenac sodium microemulsions across excised newborn pig skin. Glucam® P-20 (GP-20) or PPG-20-methyl glucose ether is generally used as a humectant, emollient and fragrance fixative. The w/o microemulsions composed of Tween 80, Eutanol G and water were formulated. The concentration of diclofenac sodium was 1 % w/w while the amounts of GP-20 were varied from 0-20 % w/w, ME-1 (0 %), ME-2 (5 %), ME-3 (10 %) and ME-4 (20 %). All microemulsions were transparent with Newtonian flow behaviour. The mean droplet sizes of the microemulsions were about 200 nm. The FTIR spectra of the microemulsions containing GP-20 were not markedly different from those of the microemulsion without GP- 20, ME-1. The in vitro release and skin permeation studies of diclofenac sodium loaded microemulsions were investigated using modified Franz diffusion cell. For the in vitro release across synthetic membrane, the rank order of the release rate was ME-4 > ME-3 > ME-2 > ME-1. For the in vitro skin permeation experiments, GP-20 at 10 % and 20 % could markedly enhance the percutaneous absorption of the drug. The optimum concentration of GP-20 was 10 %. GP-20 is proposed as a potential skin penetration enhancer for percutaneous absorption of diclofenac sodium.Colegio de Farmacéuticos de la Provincia de Buenos Aire

An overview of skin penetration enhancers: penetration enhancing activity, skin irritation potential and mechanism of action

Transdermal drug delivery has attracted considerable attention over the past 2-3 decades in regard of its many potentialadvantages. However, the role of the skin as a protective barrier renders skin absorption of most drugs problematic. Therefore,skin penetration enhancers are frequently used in the field of transdermal drug delivery in order to reversibly reduce thebarrier function of the stratum corneum, the outermost layer of the skin. To date, a wide range of chemical compounds havebeen shown to enhance the skin penetration of therapeutic drugs. This review presents a critical account of the most commonlyused chemical penetration enhancers (fatty acids and surfactants), and some newer classes of chemical enhancers (terpenes,polymers, monoolein, oxazolidinones), with emphasis on their efficacy, mechanism of action, and skin irritation potential. Thisreview also discusses the traditional and more recently developed methods for the screening and evaluation of chemical penetration enhancers, and addresses the continuing problems in the rational selection of a chemical penetration enhancer for a specific drug to be delivered via the transdermal route

Physicochemical and permeation of NSAIDs and H2-antagonist binary system

Prince of Songkla Universit

รายงานการวิจัยฉบับสมบูรณ์เรื่องการศึกษาสารเชิงซ้อนของ เบต้า-ไซโคลเด็กซ์ตรินกับน้ำมันตะไคร้หอมเพื่อไล่ยุง

Prince of Songkla University Faculty of Pharmaceutical Scienc

รายงานวิจัยฉบับสมบูรณ์การเตรียมสารสกัดเปล้าน้อยในรูปไมโคร/นาโนอิมัลชัน เพื่อรักษาผิวหนังอักเสบ

Thailand Research Fun

วิธีการใหม่ของการนำส่งยา Propranolol ผ่านทางผิวหนังโดยการใช้ระบบควบคุมการปลดปล่อยที่เลือกเฉพาะอิแนนทิโอเมอร์ : รายงานฉบับสมบูรณ์

Prince of Songkla Universit

FORMULATION AND INVESTIGATION OF ANTIOXIDANT POTENTIAL OF O/W LOTIONS CONTAINING Tamarindus indica L. FRUIT PULP EXTRACT

The fruit pulp extracts of Tamarindus indica have been reported to possess several biological activities, especially antioxidant property which is suitable for cosmetic application. Therefore, the aims of this study were to formulate the tamarind fruit pulp extract loaded lotions (o/w emulsions), and to assess the antioxidant activity of tamarind fruit pulp extract loaded lotions. Initially, tamarind fruit pulp extracts were prepared by a solvent extraction method. The solvents used were water or a mixture of water and ethanol (water: ethanol= 1:1). Afterwards, the obtained tamarind fruit pulp extracts were subjected to lyophilization process. The tamarind fruit pulp extracts were tested for antioxidant activity by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) assay to determine suitable concentrations of the extracts to be incorporated into the lotions, which were 2 and 4%w/w in the current study. Apart from the basic ingredients of the oil phase and water phase, ViscOptima SE (2%w/w) was selected as an emulsifier and a thickener of the formulations. The tamarind fruit pulp extract loaded lotions were characterized for physicochemical property and antioxidant potential. The freshly prepared tamarind fruit pulp extract loaded lotions were light brown with homogeneity and no phase separation was observed after centrifugation at 3,000 rpm for 30 min. They had weak acidic pH (4.4-5.1), considered acceptable for skin application. The loaded formulations (F1, 2%w/w) and F2, 4%w/w)) exhibited significantly higher conductivity values than that of the unloaded formulation (F0) (p<0.05). The formulations behaved as pseudoplastic flows with low viscosity. The DPPH measurement revealed that the formulations F1 and F2 had potential antioxidant activity. In conclusion, topical o/w lotions containing tamarind fruit pulp extract were successfully prepared. They had substantial antioxidant activities. As a result, tamarind fruit pulp extract loaded lotions displayed a potential use in cosmetic formulations, especially antiaging products