Guillain-Barré syndrome : causes, immunopathogenic mechanisms and treatment

Introduction: Guillain-Barr\ue9 syndrome is a rare disease representing the most frequent cause of acute flaccid symmetrical weakness of the limbs and areflexia usually reaching its peak within a month. The etiology and pathogenesis remain largely enigmatic and the syndrome results in death or severe disability in 9\u201317% of cases despite immunotherapy. Areas covered: In terms of etiology, Guillain-Barr\ue9 syndrome is linked to Campylobacter infection but less than 0.1% of infections result in the syndrome. In terms of pathogenesis, activated macrophages and T cells and serum antibodies against gangliosides are observed but their significance is unclear. Expert commentary: Guillain-Barr\ue9 syndrome is a heterogeneous condition with numerous subtypes and recent data point towards the role of ganglioside epitopes by immunohistochemical methods. Ultimately, the syndrome results from a permissive genetic background on which environmental factors, including infections, vaccination and the influence of aging, lead to disease

Sacroiliitis séptica por Escherichia coli en el puerperio tardío

Septic sacroiliitis is an unusual condition, and due to its non-specific symptoms, the diagnosis is often delayed. It should be suspected in cases in which inflammatory back pain and systemic inflammatory signs co-exist, especially in people with risk factors, such as postpartum. The case is presented of a woman, who in the late postpartum, presented with sacroiliitis and severe sepsis due to Escherichia coli. This is the second report of a case of septic sacroiliitis due to Escherichia coli associated with pregnancy. © 2016 Asociación Colombiana de Reumatología. Published by Elsevier España, S.L.U. All rights reserved

Sacroiliitis séptica por Escherichia coli en el puerperio tardío

Septic sacroiliitis is an unusual condition, and due to its non-specific symptoms, the diagnosis is often delayed. It should be suspected in cases in which inflammatory back pain and systemic inflammatory signs co-exist, especially in people with risk factors, such as postpartum. The case is presented of a woman, who in the late postpartum, presented with sacroiliitis and severe sepsis due to Escherichia coli. This is the second report of a case of septic sacroiliitis due to Escherichia coli associated with pregnancy. © 2016 Asociación Colombiana de Reumatología. Published by Elsevier España, S.L.U. All rights reserved

SAT0192 Abatacept subcutáneo en pacientes con artritis reumatoide: una experiencia de la vida real

Background Therapeutic guidelines draw heavily on evidence from randomised controlled trials undertaken in well-characterised, highly-selective populations and managed in tightly-controlled settings. As such, the extent to which therapeutic efficacy in real-life populations and routine care settings is often unclear

SAT0319 Severidad en pacientes con lupus eritematoso sistémico: un análisis de rasgos latentes

Background Systemic Lupus Erythematosus (SLE) is a complex disease which can potentially involve any organ and, therefore, has a wide range of clinical manifestations (i.e., subphenotypes

SAT0306 ¿Cómo afecta el tabaquismo el síndrome de Sjögren?

Background Cigarette smoking has been found to play a pathogenic role in several autoimmune diseases. However, data about its influence on Sjögren's syndrome (SS) is scarc

AB0354 Abatacept subcutáneo en pacientes con artritis reumatoide: una experiencia de la vida real

Background Therapeutic guidelines draw heavily on evidence from randomized controlled trials undertaken in well-characterized, highly-selective populations and managed in tightly-controlled settings. As such, the extent to which therapeutic efficacy in real-life populations and routine care settings is often unclea

SAT0015 Mutaciones nuevas y raras relacionadas con la poliautoinmunidad

Background Polyautoimmunity (i.e., the presence of two or more autoimmune diseases in a single patient) and familial autoimmunity (i.e., diverse autoimmune diseases in a nuclear family) represent extreme phenotypes ideal for identifying major genomic variants contributing to autoimmunity (1–3). Whole Exome Sequencing (WES) and linkage analysis are well suited for this purpose due to its strong resolution upon familial segregation patterns of functional protein coding and splice variant