135 research outputs found
A readily accessible porous organic polymer facilitates high-yielding Knoevenagel condensation at room temperature both in water and under solvent-free mechanochemical conditions
A novel nitrogen-rich amorphous porous organic polymer has been synthesized using a microwave-assisted process. Its high chemical stability, reusability and poor solubility enable the use of the porous polymer as a metal-free heterogeneous catalyst for CâC bond formation at ambient temperature under environmentally benign conditions
Dislocations and the enhancement of superconductivity in odd-parity superconductor SrRuO
We report observation of the enhancement of superconductivity near lattice
dislocations and the absence of the strengthening of vortex pinning in
odd-parity superconductor SrRuO, both surprising results in direct
contrast to the well known sensitivity of superconductivity in SrRuO to
disorder. The enhanced superconductivity appears to be related fundamentally to
the two-component nature of the superconducting order parameter, as revealed in
our phenomenological theory taking into account the effect of symmetry
reduction near a dislocation.Comment: 5 pages, 4 figures, submitted to Physical Review Letter
Novel Fusion of MYST/Esa1-Associated Factor 6 and PHF1 in Endometrial Stromal Sarcoma
Rearrangement of chromosome band 6p21 is recurrent in endometrial stromal sarcoma (ESS) and targets the PHF1 gene. So far, PHF1 was found to be the 3Ⲡpartner in the JAZF1-PHF1 and EPC1-PHF1 chimeras but since the 6p21 rearrangements involve also other chromosomal translocation partners, other PHF1-fusions seem likely. Here, we show that PHF1 is recombined with a novel fusion partner, MEAF6 from 1p34, in an ESS carrying a t(1;6)(p34;p21) translocation as the sole karyotypic anomaly. 5â˛-RACE, RT-PCR, and sequencing showed the presence of an MEAF6-PHF1 chimera in the tumor with exon 5 of MEAF6 being fused in-frame to exon 2 of PHF1 so that the entire PHF1 coding region becomes the 3Ⲡterminal part of the MEAF6-PHF1 fusion. The predicted fusion protein is composed of 750 amino acids and contains the histone acetyltransferase subunit NuA4 domain of MEAF6 and the tudor, PHD zinc finger, and MTF2 domains of PHF1. Although the specific functions of the MEAF6 and PHF1 proteins and why they are targeted by a neoplasia-specific gene fusion are not directly apparent, it seems that rearrangement of genes involved in acetylation (EPC1, MEAF6) and methylation (PHF1), resulting in aberrant gene expression, is a common theme in ESS pathogenesis
Van der Waals heterostructures
Research on graphene and other two-dimensional atomic crystals is intense and
likely to remain one of the hottest topics in condensed matter physics and
materials science for many years. Looking beyond this field, isolated atomic
planes can also be reassembled into designer heterostructures made layer by
layer in a precisely chosen sequence. The first - already remarkably complex -
such heterostructures (referred to as 'van der Waals') have recently been
fabricated and investigated revealing unusual properties and new phenomena.
Here we review this emerging research area and attempt to identify future
directions. With steady improvement in fabrication techniques, van der Waals
heterostructures promise a new gold rush, rather than a graphene aftershock
Hydrogeological typologies of the Indo-Gangetic basin alluvial aquifer, South Asia
The Indo-Gangetic aquifer is one of the worldâs most important transboundary water resources, and the most heavily exploited aquifer in the world. To better understand the aquifer system, typologies have been characterized for the aquifer, which integrate existing datasets across the Indo-Gangetic catchment basin at a transboundary scale for the first time, and provide an alternative conceptualization of this aquifer system. Traditionally considered and mapped as a single homogenous aquifer of comparable aquifer properties and groundwater resource at a transboundary scale, the typologies illuminate significant spatial differences in recharge, permeability, storage, and groundwater chemistry across the aquifer system at this transboundary scale. These changes are shown to be systematic, concurrent with large-scale changes in sedimentology of the Pleistocene and Holocene alluvial aquifer, climate, and recent irrigation practices. Seven typologies of the aquifer are presented, each having a distinct set of challenges and opportunities for groundwater development and a different resilience to abstraction and climate change. The seven typologies are: (1) the piedmont margin, (2) the Upper Indus and Upper-Mid Ganges, (3) the Lower Ganges and Mid Brahmaputra, (4) the fluvially influenced deltaic area of the Bengal Basin, (5) the Middle Indus and Upper Ganges, (6) the Lower Indus, and (7) the marine-influenced deltaic areas
Antimalarial drug targets in Plasmodium falciparum predicted by stage-specific metabolic network analysis
Viral, bacterial, and fungal infections of the oral mucosa:Types, incidence, predisposing factors, diagnostic algorithms, and management
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