1,847 research outputs found

    Bacterial and fungal infections in liver transplant recipients

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    Influence of Humidity on the NOβ‚‚ Sensing Properties of SrCoβ‚€.₁Tiβ‚€.₉O₃

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    Strontium Cobalt Titanate (SCT) was synthesized via solid state route. Phase formation was analyzed using X-ray diffraction (XRD) technique. Resistive sensors were made using screen printing technique and corresponding sensing properties were investigated in dry as well as humid environment (RH 50%). Experimental results demonstrated that sensors displayed least humidity interference at 400 Β°C. The operating temperature of the sensor was optimized for best responsiveness. These type of sensors can be effectively used in environmental monitoring of NO2 gas at low ppm

    Role of actin dependent nuclear deformation in regulating early gene expression

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    The nucleus of a living cell is constantly undergoing changes in shape and size as a result of various mechanical forces in physiology. These changes correlate with alterations in gene expression, however it is unclear whether nuclear deformation alone is sufficient to elicit these alterations. We used T-cell activation as a model system to test the coupling between nuclear deformation (elongation) and gene expression. NaΓ―ve T-cell activation with surrogate antigens resulted in actin dependent nuclear elongation. This was accompanied with Erk and NF-ΞΊB signaling to the nucleus to induce CD69 expression. Importantly, inhibiting actin polymerization abolished both nuclear elongation and CD69 expression, while inhibiting Erk, NF-ΞΊB or microtubule depolymerization only abolished expression but not elongation. Immobilization of antigen-coated beads, under conditions where actin polymerization was inhibited, rescued both nuclear elongation and CD69 expression. In addition, fibroblast cells plated on fibronectin micropatterns of different sizes showed correlation between nuclear shape index and tenascin C expression. Upon inhibiting the signaling intermediate Erk, tenascin C expression was down regulated although the nuclear shape index remained unaltered. Our results highlight the importance of specific signaling intermediates accompanied with nuclear deformation in the modulation of cellular genomic programs

    A Metamaterial Backed Dipole Antenna for High Gain Directional Communications

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    The enhanced radiation performance of a dipole antenna backed by the split ring resonator-continuous wire pair array working in the Hβ”΄ excitation scenario is presented in this paper.Β  The Hβ”΄ excitation scenario of the metamaterial is used to get zero reflection phase resulting in enhanced gain performance. The two layer meta-structure along with the dipole is fabricated on a low cost substrate of dielectric constant 4.4 and height 1mm. The reflection properties of the metamaterial structure and its effect on the radiation performance of the dipole antenna are presented in this paper

    НСйтронографичСскоС исслСдованиС структурного ΠΏΠ΅Ρ€Π΅Ρ…ΠΎΠ΄Π° ΠΊΡƒΠ±ΠΈΡ‡Π΅ΡΠΊΠ°Ρβ€“Ρ‚Π΅Ρ‚Ρ€Π°Π³ΠΎΠ½Π°Π»ΡŒΠ½Π°Ρ Ρ„Π°Π·Π° Π² монокристаллах Ρ‚Π²Π΅Ρ€Π΄Ρ‹Ρ… растворов оксида циркония с оксидом иттрия

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    Objectives. The determination of the phase relations, crystallographic characteristics, microstructure features, and atomic crystal structure of zirconium oxide crystals that are partially and completely stabilized by yttrium oxide additives, and the identification of the crystallographic and crystal-chemical correlations with the physicochemical properties of single crystals.Methods. The neutron structure of the crystals was studied using the neutron time-of-flight and constant wavelength methods using a high-resolution Fourier diffractometer on the IBR-2 pulsed fast reactor and a four-circle neutron diffractometer β€œSyntex.” Single crystals were grown by directed crystallization from the melts of mixtures (1 βˆ’ Ρ…)ZrO2 βˆ™Ρ…Y2O3 , Ρ… = 0.03 and Ρ… = 0.12 with different growth rates (10 and 40 mm/h).Results. It was observed that when growing single crystals with x = 0.03–0.05, the crystal was stratified into cubic and tetragonal phases, and the ratio between the phases depended on the growth rate. At a growth rate of 40 mm/h, the content of the cubic phase was insignificant. In the crystals of partially stabilized zirconium dioxide (ZrO2) with the additions of 3 mol % Y2O3, the coherent coexistence of cubic and tetragonal phases was established, and the twin law for a tetragonal component (rotation of unit cell axis by 90Β° around the a (b) axis) that was observed during the phase transition from high-temperature cubic phase to tetragonal phase was determined. For the fully stabilized zirconium oxide of the cubic symmetry (with 12 mol % Y2O3), the 0.3 Γ… displacements of oxygen atoms from their partial structural positions in the directions [100] and [111] were determined. These displacements correlated with the directions of the ion transport.Conclusions. Previous studies have shown that the ratio between the cubic and tetragonal phases of the single crystals of the ZrO2 –Y2O3 system depends on the growth rate of the single crystals. The content of Y2O3 in the cubic and tetragonal phases of a single crystal was determined using the non-destructive neutronography method on the same volume sample of a solid solution of this system. Moreover, the displacements of oxygen atoms from the main position of the crystal were determined.Π¦Π΅Π»ΠΈ. ΠžΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ Ρ„Π°Π·ΠΎΠ²Ρ‹Ρ… ΡΠΎΠΎΡ‚Π½ΠΎΡˆΠ΅Π½ΠΈΠΉ, кристаллографичСских характСристик, особСнностСй микроструктуры ΠΈ Π°Ρ‚ΠΎΠΌΠ½ΠΎ-кристалличСской структуры кристаллов оксида циркония, частично ΠΈ ΠΏΠΎΠ»Π½ΠΎΡΡ‚ΡŒΡŽ стабилизированных Π΄ΠΎΠ±Π°Π²ΠΊΠ°ΠΌΠΈ оксида иттрия, выявлСниС кристаллографичСских ΠΈ кристаллохимичСских коррСляций с Ρ„ΠΈΠ·ΠΈΠΊΠΎ-химичСскими свойствами монокристаллов.ΠœΠ΅Ρ‚ΠΎΠ΄Ρ‹. НСйтроноструктурныС исслСдования кристаллов ΠΏΡ€ΠΎΠ²Π΅Π΄Π΅Π½Ρ‹ ΠΌΠ΅Ρ‚ΠΎΠ΄Π°ΠΌΠΈ Π²Ρ€Π΅ΠΌΠ΅Π½ΠΈ ΠΏΡ€ΠΎΠ»Π΅Ρ‚Π° Π½Π΅ΠΉΡ‚Ρ€ΠΎΠ½ΠΎΠ² ΠΈ постоянной Π΄Π»ΠΈΠ½Ρ‹ Π²ΠΎΠ»Π½Ρ‹ с использованиСм Π€ΡƒΡ€ΡŒΠ΅ Π΄ΠΈΡ„Ρ€Π°ΠΊΡ‚ΠΎΠΌΠ΅Ρ‚Ρ€Π° высокого Ρ€Π°Π·Ρ€Π΅ΡˆΠ΅Π½ΠΈΡ Π½Π° ΠΈΠΌΠΏΡƒΠ»ΡŒΡΠ½ΠΎΠΌ быстром Ρ€Π΅Π°ΠΊΡ‚ΠΎΡ€Π΅ Π˜Π‘Π -2 ΠΈ Ρ‡Π΅Ρ‚Ρ‹Ρ€Π΅Ρ…ΠΊΡ€ΡƒΠΆΠ½ΠΎΠ³ΠΎ Π½Π΅ΠΉΡ‚Ρ€ΠΎΠ½Π½ΠΎΠ³ΠΎ Π΄ΠΈΡ„Ρ€Π°ΠΊΡ‚ΠΎΠΌΠ΅Ρ‚Ρ€Π° «БинтСкс». ΠœΠΎΠ½ΠΎΠΊΡ€ΠΈΡΡ‚Π°Π»Π»Ρ‹ Π±Ρ‹Π»ΠΈ Π²Ρ‹Ρ€Π°Ρ‰Π΅Π½Ρ‹ Π½Π°ΠΏΡ€Π°Π²Π»Π΅Π½Π½ΠΎΠΉ кристаллизациСй ΠΈΠ· расплавов смСсСй (1 – Ρ…)ZrO2 βˆ™Ρ…Y2O3 , Ρ… = 0.03 ΠΈ 0.12 с Ρ€Π°Π·Π½Ρ‹ΠΌΠΈ скоростями роста (10 ΠΈ 40 ΠΌΠΌ/Ρ‡).Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹. УстановлСно, Ρ‡Ρ‚ΠΎ ΠΏΡ€ΠΈ Π²Ρ‹Ρ€Π°Ρ‰ΠΈΠ²Π°Π½ΠΈΠΈ монокристаллов с Ρ… = 0.03–0.05 происходит расслоСниС кристалла Π½Π° ΠΊΡƒΠ±ΠΈΡ‡Π΅ΡΠΊΡƒΡŽ ΠΈ Ρ‚Π΅Ρ‚Ρ€Π°Π³ΠΎΠ½Π°Π»ΡŒΠ½ΡƒΡŽ Ρ„Π°Π·Ρ‹, ΡΠΎΠΎΡ‚Π½ΠΎΡˆΠ΅Π½ΠΈΠ΅ ΠΌΠ΅ΠΆΠ΄Ρƒ ΠΊΠΎΡ‚ΠΎΡ€Ρ‹ΠΌΠΈ зависит ΠΎΡ‚ скорости выращивания. ΠŸΡ€ΠΈ скорости роста 40 ΠΌΠΌ/Ρ‡ содСрТаниС кубичСской Ρ„Π°Π·Ρ‹ Π½Π΅Π·Π½Π°Ρ‡ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎ. Π’ кристаллах частично стабилизированного диоксида циркония ZrO2 (c Π΄ΠΎΠ±Π°Π²ΠΊΠ°ΠΌΠΈ 3 mol % Y2O3) установлСно ΠΊΠΎΠ³Π΅Ρ€Π΅Π½Ρ‚Π½ΠΎΠ΅ сосущСствованиС кубичСской ΠΈ Ρ‚Π΅Ρ‚Ρ€Π°Π³ΠΎΠ½Π°Π»ΡŒΠ½ΠΎΠΉ Ρ„Π°Π· ΠΈ ΠΎΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½ Π·Π°ΠΊΠΎΠ½ двойникования для Ρ‚Π΅Ρ‚Ρ€Π°Π³ΠΎΠ½Π°Π»ΡŒΠ½ΠΎΠΉ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½Ρ‚Ρ‹ (Π²Ρ€Π°Ρ‰Π΅Π½ΠΈΠ΅ осСй элСмСнтарной ячСйки Π½Π° 90Β° Π²ΠΎΠΊΡ€ΡƒΠ³ осСй a (b)), Π²ΠΎΠ·Π½ΠΈΠΊΠ°ΡŽΡ‰Π΅Π³ΠΎ ΠΏΡ€ΠΈ Ρ„Π°Π·ΠΎΠ²ΠΎΠΌ ΠΏΠ΅Ρ€Π΅Ρ…ΠΎΠ΄Π΅ ΠΈΠ· высокотСмпСратурной кубичСской Ρ„Π°Π·Ρ‹ Π² Ρ‚Π΅Ρ‚Ρ€Π°Π³ΠΎΠ½Π°Π»ΡŒΠ½ΡƒΡŽ. Для ΠΏΠΎΠ»Π½ΠΎΡΡ‚ΡŒΡŽ стабилизированного диоксида циркония кубичСской симмСтрии (с 12 mol % Y2O3) ΠΎΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½Ρ‹ смСщСния Π°Ρ‚ΠΎΠΌΠΎΠ² кислорода Π½Π° 0.3 Γ… ΠΈΠ· ΠΈΡ… частных структурных ΠΏΠΎΠ·ΠΈΡ†ΠΈΠΉ Π² направлСниях [100] ΠΈ [111]. Π­Ρ‚ΠΈ смСщСния ΠΊΠΎΡ€Ρ€Π΅Π»ΠΈΡ€ΡƒΠ΅Ρ‚ с направлСниями ΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ транспорта.Π’Ρ‹Π²ΠΎΠ΄Ρ‹. ИсслСдования ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΈ, Ρ‡Ρ‚ΠΎ ΡΠΎΠΎΡ‚Π½ΠΎΡˆΠ΅Π½ΠΈΠ΅ ΠΌΠ΅ΠΆΠ΄Ρƒ кубичСской Ρ„Π°Π·ΠΎΠΉ ΠΈ Ρ‚Π΅Ρ‚Ρ€Π°Π³ΠΎΠ½Π°Π»ΡŒΠ½ΠΎΠΉ Ρ„Π°Π·ΠΎΠΉ монокристаллов систСмы ZrO2 –Y2O3 зависит ΠΎΡ‚ скорости выращивания монокристаллов. На ΠΎΠ΄Π½ΠΎΠΌ ΠΈ Ρ‚ΠΎΠΌ ΠΆΠ΅ объСмном ΠΎΠ±Ρ€Π°Π·Ρ†Π΅ Ρ‚Π²Π΅Ρ€Π΄ΠΎΠ³ΠΎ раствора этой систСмы Π½Π΅Ρ€Π°Π·Ρ€ΡƒΡˆΠ°ΡŽΡ‰ΠΈΠΌ ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠΌ Π½Π΅ΠΉΡ‚Ρ€ΠΎΠ½ΠΎΠ³Ρ€Π°Ρ„ΠΈΠΈ ΠΎΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½ΠΎ содСрТаниС Y2O3 ΠΈ Π² кубичСской, ΠΈ Π² Ρ‚Π΅Ρ‚Ρ€Π°Π³ΠΎΠ½Π°Π»ΡŒΠ½ΠΎΠΉ Ρ„Π°Π·Π΅ монокристалла. ΠžΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½Ρ‹ смСщСния Π°Ρ‚ΠΎΠΌΠΎΠ² кислорода ΠΈΠ· основной ΠΏΠΎΠ·ΠΈΡ†ΠΈΠΈ кристалла

    Bacteriophage Infection of the Marine Bacterium Shewanella glacialimarina Induces Dynamic Changes in tRNA Modifications

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    Viruses are obligate intracellular parasites that, throughout evolution, have adapted numerous strategies to control the translation machinery, including the modulation of post-transcriptional modifications (PTMs) on transfer RNA (tRNA). PTMs are critical translation regulators used to further host immune responses as well as the expression of viral proteins. Yet, we lack critical insight into the temporal dynamics of infection-induced changes to the tRNA modification landscape (i.e., β€˜modificome’). In this study, we provide the first comprehensive quantitative characterization of the tRNA modificome in the marine bacterium Shewanella glacialimarina during Shewanella phage 1/4 infection. Specifically, we show that PTMs can be grouped into distinct categories based on modification level changes at various infection stages. Furthermore, we observe a preference for the UAC codon in viral transcripts expressed at the late stage of infection, which coincides with an increase in queuosine modification. Queuosine appears exclusively on tRNAs with GUN anticodons, suggesting a correlation between phage codon usage and PTM modification. Importantly, this work provides the basis for further studies into RNA-based regulatory mechanisms employed by bacteriophages to control the prokaryotic translation machinery

    Measuring the nuclear equation of state with neutron star-black hole mergers

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    Gravitational-wave (GW) observations of neutron star-black hole (NSBH) mergers are sensitive to the nuclear equation of state (EOS). Using realistic simulations of NSBH mergers, incorporating both GW and electromagnetic (EM) selection to ensure sample purity, we find that a GW detector network operating at O5-sensitivities will constrain the radius of a 1.4Β MβŠ™1.4~M_{\odot} NS and the maximum NS mass with 1.6%1.6\% and 13%13\% precision, respectively. The results demonstrate strong potential for insights into the nuclear EOS, provided NSBH systems are robustly identified.Comment: 9 pages, 4 Figures. Submitted. Comments welcome

    Silicon Pad Detectors for the PHOBOS Experiment at RHIC

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    The PHOBOS experiment is well positioned to obtain crucial information about relativistic heavy ion collisions at RHIC, combining a multiplicity counter with a multi-particle spectrometer. The multiplicity arrays will measure the charged particle multiplicity over the full solid angle. The spectrometer will be able to identify particles at mid-rapidity. The experiment is constructed almost exclusively of silicon pad detectors. Detectors of nine different types are configured in the multiplicity and vertex detector (22,000 channels) and two multi-particle spectrometers (120,000 channels). The overall layout of the experiment, testing of the silicon sensors and the performance of the detectors during the engineering run at RHIC in 1999 are discussed.Comment: 7 pages, 7 figures, 1 table, Late

    A Metamaterial Backed Dipole Antenna for High Gain Directional Communications

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    The enhanced radiation performance of a dipole antenna backed by the split ring resonator-continuous wire pair array working in the Hβ”΄ excitation scenario is presented in this paper.  The Hβ”΄ excitation scenario of the metamaterial is used to get zero reflection phase resulting in enhanced gain performance. The two layer meta-structure along with the dipole is fabricated on a low cost substrate of dielectric constant 4.4 and height 1mm. The reflection properties of the metamaterial structure and its effect on the radiation performance of the dipole antenna are presented in this paper
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