All Librarianship is Political: Educate Accordingly

After participating in a multi-year project considering the future directions for library and information science (LIS) education, the authors of this paper realized an essential aspect of the nature of libraries and librarianship was continually overlooked or sidestepped in the events and discussions. That is, libraries as institutions and many of the actions of library professionals are inherently political, yet LIS education has not traditionally prepared students for them. Confronting this aspect of LIS education and the profession in general and creating curriculum that emphasizes the politics of librarianship will better prepare students to serve their patrons, their communities, and their institutions. Such an educational approach would emphasize preparing future library professionals in areas such as leadership, education, activism and advocacy, community service and engagement, policy and law, rights and justice, and marketing and evaluation, resulting in the politically-savvy librarians ready to be activists for their institutions and communities. This paper explores the design of library education, criticism of library education, and the actual environment of contemporary librarians as the context for suggesting this significant change in the focus of library education. We live in a political world, and it’s time we prepare our students for this world

Comparing Platforms for C. elegans Mutant Identification Using High-Throughput Whole-Genome Sequencing

Whole-genome sequencing represents a promising approach to pinpoint chemically induced mutations in genetic model organisms, thereby short-cutting time-consuming genetic mapping efforts.We compare here the ability of two leading high-throughput platforms for paired-end deep sequencing, SOLiD (ABI) and Genome Analyzer (Illumina; "Solexa"), to achieve the goal of mutant detection. As a test case we used a mutant C. elegans strain that harbors a mutation in the lsy-12 locus which we compare to the reference wild-type genome sequence. We analyzed the accuracy, sensitivity, and depth-coverage characteristics of the two platforms. Both platforms were able to identify the mutation that causes the phenotype of the mutant C. elegans strain, lsy-12. Based on a 4 MB genomic region in which individual variants were validated by Sanger sequencing, we observe tradeoffs between rates of false positives and false negatives when using both platforms under similar coverage and mapping criteria.In conclusion, whole-genome sequencing conducted by either platform is a viable approach for the identification of single-nucleotide variations in the C. elegans genome

Mergers of double neutron stars with one high-spin component: brighter kilonovae and fallback accretion, weaker gravitational waves

Neutron star mergers where both stars have negligible spins are commonly considered as the most likely, "standard" case. But based on observed systems, we estimate that actually a non-negligible fraction of all double neutron star mergers ($\sim$ 5 %) may contain one millisecond component. We use the Lagrangian Numerical Relativity code SPHINCS_BSSN to simulate mergers where one star has no spin and the other has a dimensionless spin parameter of $\chi=0.5$. These mergers exhibit several distinct signatures compared to irrotational cases. Morphologically, they are similar to unequal mass mergers and they form in particular only one, very pronounced spiral arm. Compared to the non-spinning cases, they dynamically eject an order of magnitude more mass of unshocked material at the original low electron fraction of the neutron stars and therefore produce particularly bright, red kilonovae and brighter kilonova afterglows months after the merger. We also find that the spinning cases have significantly more fallback accretion, with implications for late-time X-ray flares and the duration of the associated gamma-ray burst. Overall, the spinning case collisions are substantially less violent and they emit smaller amounts of shock-generated semi-relativistic material and therefore produce less pronounced blue/UV kilonova precursor signals. Their post-merger gravitational wave signal is weaker and, during the simulated time, substantially smaller amounts of energy and angular momentum are emitted. Therefore the central remnant contains a larger angular momentum reservoir and could remain an "active engine" for a longer time.Comment: 17 pages, 15 figures, submitte

Disparate Osteogenic Response of Mandible and Iliac Crest Bone Marrow Stromal Cells to Pamidronate

OBJECTIVE Long-term administration of intravenous bisphosphonates like pamidronate is associated with jaw osteonecrosis but axial and appendicular bones are unaffected. Pathogenesis of bisphosphonate-associated jaw osteonecrosis may relate to skeletal-site specific effects of bisphosphonates on osteogenic differentiation of bone marrow stromal cells (BMSCs) of orofacial and axial/appendicular bones. This study evaluated and compared skeletal site-specific osteogenic response of mandible (orofacial bone) and iliac crest (axial bone) human BMSCs to pamidronate. MATERIALS AND METHODS Mandible and iliac crest BMSCs from six normal healthy volunteers were established in culture and tested with pamidronate to evaluate and compare cell survival, osteogenic marker alkaline phosphatase, osteoclast differentiation in co-cultures with CD34+ hematopoietic stem cells, gene expression of receptor activator of NFκB ligand (RANKL) and osteoprotegerin, and in vivo bone regeneration. BRESULTS Mandible BMSCs were more susceptible to pamidronate than iliac crest BMSCs based on decreased cell survival, lower alkaline phosphatase production and structurally less organized in vivo bone regeneration. Pamidronate promoted higher RANKL gene expression and osteoclast recruitment by mandible BMSCs. CONCLUSION Mandible and iliac crest BMSC survival and osteogenic differentiation are disparately affected by pamidronate to favor dysregulated mandible bone homeostasis

An exploratory examination of marijuana use, problem-gambling severity, and health correlates among adolescents

Abstract Background and aims Gambling is common in adolescents and at-risk and problem/pathological gambling (ARPG) is associated with adverse measures of health and functioning in this population. Although ARPG commonly co-occurs with marijuana use, little is known how marijuana use influences the relationship between problem-gambling severity and health- and gambling-related measures. Methods Survey data from 2,252 Connecticut high school students were analyzed using chi-square and logistic regression analyses. Results ARPG was found more frequently in adolescents with lifetime marijuana use than in adolescents denying marijuana use. Marijuana use was associated with more severe and a higher frequency of gambling-related behaviors and different motivations for gambling. Multiple health/functioning impairments were differentially associated with problem-gambling severity amongst adolescents with and without marijuana use. Significant marijuana-use-by-problem-gambling-severity-group interactions were observed for low-average grades (OR = 0.39, 95% CI = [0.20, 0.77]), cigarette smoking (OR = 0.38, 95% CI = [0.17, 0.83]), current alcohol use (OR = 0.36, 95% CI = [0.14, 0.91]), and gambling with friends (OR = 0.47, 95% CI = [0.28, 0.77]). In all cases, weaker associations between problem-gambling severity and health/functioning correlates were observed in the marijuana-use group as compared to the marijuana-non-use group. Conclusions Some academic, substance use, and social factors related to problem-gambling severity may be partially accounted for by a relationship with marijuana use. Identifying specific factors that underlie the relationships between specific attitudes and behaviors with gambling problems and marijuana use may help improve intervention strategies