Beam Shape and Halo Monitor Study

The Beam Shape and Halo Monitor, designed by Masaki Hori, is the main diagnostic tool for the 3 MeV test stand scheduled in 2008. This detector will be able to measure the transverse halo generated in the RFQ and the Chopper-line and to detect and measure the longitudinal halo composed of the incompletely chopped bunches. Its principle of functioning is the following: H- ions hit a carbon foil and generate secondary electrons with the same spatial distribution than the incoming beam and a current depending on an emission coefficient given by the carbon foil. These electrons are accelerated towards a phosphor screen by an electric field applied between accelerating grids. Once the electrons reach the phosphor screen, they generate light which is transmitted to a CCD camera via optic fibers [1]. It is expected to give a time resolution of 1-2ns and a spatial resolution of 1mm. The first test of the BSHM done with a Laser has shown a spatial resolution bigger than 1cm and the time resolution bigger than 2ns[2]. The purpose of this study is to understand what are the processes which deteriorate the resolution and to show the benefits brought by adding a pre-accelerating grid in the detector

End-to end simulations of LINAC4

Linac4 is a new H- linear accelerator presently studied at CERN. This machine consists of normal-conducting structures operating at 352.2 MHz and 704.4 MHz re-using the RF equipment from the decommissioned LEP collider. It consists of a 95 keV H- source, a 352 MHz RFQ bringing the energy the energy to 3 MeV, a Chopper line, a 352 MHz Drift Tube Linac bringing the energy to 40 MeV, a 352 MHz Coupled Cavity Drift Tube Linac bringing the energy to 90 MeV and a 704 MHz Side Coupled Linac bringing the energy to 160 MeV. Each section is designed and optimized as stand-alone machines for a good transmission and minimum possible emittance growth. End-to-end simulations starting from the RFQ have been carried out in order to validate and compare the multiparticle simulation codes PATH Manager and TRACEWIN used for beam dynamics calculations as well as to perform a global optimization of the structures in the context of a complex machine

Calmodulin affects sensitization of Drosophila melanogaster odorant receptors

Flying insects have developed a remarkably sensitive olfactory system to detect faint and turbulent odor traces. This ability is linked to the olfactory receptors class of odorant receptors (ORs), occurring exclusively in winged insects. ORs form heteromeric complexes of an odorant specific receptor protein (OrX) and a highly conserved co-receptor protein (Orco). The ORs form ligand gated ion channels that are tuned by intracellular signaling systems. Repetitive subthreshold odor stimulation of olfactory sensory neurons sensitizes insect ORs. This OR sensitization process requires Orco activity. In the present study we first asked whether OR sensitization can be monitored with heterologously expressed OR proteins. Using electrophysiological and calcium imaging methods we demonstrate that D. melanogaster OR proteins expressed in CHO cells show sensitization upon repeated weak stimulation. This was found for OR channels formed by Orco as well as by Or22a or Or56a and Orco. Moreover, we show that inhibition of calmodulin (CaM) action on OR proteins, expressed in CHO cells, abolishes any sensitization. Finally, we investigated the sensitization phenomenon using an ex vivo preparation of olfactory sensory neurons (OSNs) expressing Or22a inside the fly's antenna. Using calcium imaging, we observed sensitization in the dendrites as well as in the soma. Inhibition of calmodulin with W7 disrupted the sensitization within the outer dendritic shaft, whereas the sensitization remained in the other OSN compartments. Taken together, our results suggest that CaM action is involved in sensitizing the OR complex and that this mechanisms accounts for the sensitization in the outer dendrites, whereas further mechanisms contribute to the sensitization observed in the other OSN compartments. The use of heterologously expressed OR proteins appears to be suitable for further investigations on the mechanistic basis of OR sensitization, while investigations on native neurons are required to study the presently unknown additional mechanisms involved in OSN sensitization

Measurements of energy spectra of relativistic electrons and gamma-rays from avalanches developed in the thunderous atmosphere with Aragats Solar Neutron Telescope

Aragats solar neutron telescope (ASNT) is a unique instrument allowing to measure the energy spectra of electrons accelerated and multiplied in the strong electric fields of the atmosphere. We describe the instrument setup, its operation condition, software, and hardware triggers. We present energy spectra of a very large thunderstorm ground enhancement (TGE) event observed on 6 October 2021. The detector response function, algorithm to recover energy spectra from the energy release histograms also are presented. The spectra recovery procedure is verified by simulation of the response function of the SEVAN detector, operating nearby ASNT. SEVAN is a stacked 3 layered detector, interlayered by lead filters registering both charged and neutral species of cosmic rays. The simulated and measured count rates of all 3 layers of the SEVAN detector show good agreement within 20%

Catalog of 2017 Thunderstorm Ground Enhancement (TGE) events observed on Aragats

The natural electron accelerator in the clouds above Aragats high-altitude research station in Armenia operates continuously in 2017 providing more than 100 Thunderstorm Ground enhancements (TGEs). Most important discovery based on analysis of 2017 data is observation and detailed description of the long-lasting TGEs. We present TGE catalog for 2 broad classes according to presence or absence of the high-energy particles. In the catalog was summarized several key parameters of the TGEs and related meteorological and atmospheric discharge observations. The statistical analysis of the data collected in tables reveals the months when TGEs are more frequent, the daytime when TGEs mostly occurred, the mean distance to lightning flash that terminates TGE and many other interesting relations. Separately was discussed the sharp count rate decline and following removal of high-energy particles from the TGE flux after a lightning flash. ADEI multivariate visualization and statistical analysis platform make analytical work on sophisticated problems rather easy; one can try and test many hypotheses very fast and come to a definite conclusion allowing crosscheck and validation