Changes of Insulin Resistance and Adipokines Following Supplementation with Glycyrrhiza Glabra L. Extract in Combination with a Low-Calorie Diet in Overweight and Obese Subjects: a Randomized Double Blind Clinical Trial

Purpose: Adipose tissue is a highly active endocrine organ which plays a key role in energy homeostasis. The aim of this study was to determine the effects of dried licorice extract along with a calorie restricted diet on body composition, insulin resistance and adipokines in overweight and obese subjects. Methods: Sixty-four overweight and obese volunteers (27 men, 37 women) were recruited into this double-blind, placebo-controlled, randomized, clinical trial. Participants were randomly allocated to the Licorice (n=32) or the placebo group (n=32), and each group received a low-calorie diet with either 1.5 g/day of Licorice extract or placebo for 8 weeks. Biochemical parameters, anthropometric indices, body composition and dietary intake were measured at baseline and at the end of the study. Results: A total of 58 subjects completed the trial. No side effects were observed following licorice supplementation. At the end of the study, waist circumference, fat mass, serum levels of vaspin, zinc-α2 glycoprotein, insulin and HOMA-IR were significantly decreased in the intervention group, but only the reduction in serum vaspin levels in the licorice group was significant when compared to the placebo group (p<0.01). Conclusion: Supplementation with dried licorice extract plus a low-calorie diet can increase vaspin levels in obese subjects. However, the anti-obesity effects of the intervention were not stronger than a low-calorie diet alone in the management of obesity

<span style="font-size:15.0pt;mso-bidi-font-size:14.0pt;color:black;mso-bidi-font-weight: bold" lang="EN-US">Different types of <i>Mizaj</i> (temperament) in relation with body composition in overweight and obese women: Avicenna’s opinion </span>

240-243The aim of the present study was to determine different types of Mizaj and their association with body composition in overweight and obese women. In this cross-sectional study, 135 overweight and obese women aged 18-30 yrs old were recruited from April to June 2013 in Tabriz-Iran. Weight, height and body composition (fat mass (FM), fat free mass (FFM) and total body water (TBW)) were measured and body mass index (BMI) was calculated. Determination of Mizaj type (Safravi, Saudavi, Damavi, Balghami) was performed with face to face interview by traditional medicine specialist. Data analysis was performed using SPSS software version 16.0. P<0.05 was considered significant. Mean age and BMI of participants were 25.5±3 yrs and 33±4.3kg/m2, respectively. Frequencies of subjects with Safravi, Saudavi, Damavi and Balghami temperaments were 31, 14, 47.4 and 7.4%, respectively. Most participants had Mizaj of Dam. No significant differences were observed in body weight and BMI values among different types of Mizaj (p>0.05 in both variables), but comparison percentage of FM among women, indicated significant differences between %FM in women with Mizaj of Sauda and Dam (P<0.01). However, further studies are needed to clarify association between type of Mizaj with weight and body composition. </span

Diabetic retinopathy as the leading cause of blindness and early predictor of cascading complications — risks and mitigation

Proliferative diabetic retinopathy (PDR) the sequel of diabetic retinopathy (DR), a frequent complication of diabetes mellitus (DM), is the leading cause of blindness in the working-age population. The current screening process for the DR risk is not sufficiently effective such that often the disease is undetected until irreversible damage occurs. Diabetes-associated small vessel disease and neuroretinal changes create a vicious cycle resulting in the conversion of DR into PDR with characteristic ocular attributes including excessive mitochondrial and retinal cell damage, chronic inflammation, neovascularisation, and reduced visual field. PDR is considered an independent predictor of other severe diabetic complications such as ischemic stroke. A “domino effect” is highly characteristic for the cascading DM complications in which DR is an early indicator of impaired molecular and visual signaling. Mitochondrial health control is clinically relevant in DR management, and multi-omic tear fluid analysis can be instrumental for DR prognosis and PDR prediction. Altered metabolic pathways and bioenergetics, microvascular deficits and small vessel disease, chronic inflammation, and excessive tissue remodelling are in focus of this article as evidence-based targets for a predictive approach to develop diagnosis and treatment algorithms tailored to the individual for a cost-effective early prevention by implementing the paradigm shift from reactive medicine to predictive, preventive, and personalized medicine (PPPM) in primary and secondary DR care management.</p