A study on abuse of topical corticosteroids in patients who attended dermatology venerology leprosy outpatient department

Background: Topical corticosteroids (TCs) are widely used in the patients affected with dermatoses. Abuse of these agents may cause severe adverse effects. Aim of the study was to study the abuse of TCs in patient who attend Dermatology, Venereology, and Leprosy (DVL) outpatient department. Methods: This prospective observational study was conducted in department of DVL at Rajah Muthiah Medical college, Tamil Nadu during the period of six months from November 2018 to April 2019. The patients were enrolled for the study based on inclusion and exclusion criteria.Results: Totally 50 patients with adverse drug reactions (ADRs) by the abuse of TCs were enrolled for the study. It was found that TCs were abused in all ages and equally in both genders. Nearly 72% of the people used TCs for Tinea infection and 20% of the people used TCs for acne vulgaris. Very high potent TCs such as betamethasone and beclomethasone were abused by 55% of the patient. Tinea incognito (TI) was found as common ADRs by the abuse of TCs (74%). Nearly 88% of the people bought TCs from pharmacies without prescription. Sixteen brands were found as easily accessible and affordable for the patients. Medication adherence were increased by 60% after the patient counselling.Conclusion: This study concludes, TI was found as a common ADR in patients who abused TCs such as betamethasone, beclomethasone and clobetasol. High potent TCs should not be allowed to dispense without prescription. Withdrawal of TCs will reduce the risk of ADRs

Thermally Induced Disorder-Order Phase Transition of Gd 2 Hf 2 O 7 :Eu 3+ Nanoparticles and its Implication on Photo-and Radioluminescence

Crystal structure has a strong influence on the luminescence properties of lanthanide-doped materials. In this work, we have investigated the thermally induced structural transition in Gd 2 Hf 2 O 7 (GHO) using Eu 3+ ions as the spectroscopic probe. It was found that complete phase transition from the disordered fluorite phase (DFP) to the ordered pyrochlore phase (OPP) can be achieved in GHO with the increase of annealing temperature from 650 ? 1100 ? 1300 °C. OPP is the more stable structural form for the GHOE nanoparticles (NPs) annealed at a higher temperature based on the energy calculation by density functional theory (DFT). The asymmetry ratio of the GHOE-650 NPs was the highest, whereas the quantum yield, luminescence intensity, and lifetime values of the GHOE-1300 NPs were the highest. Emission intensity of Eu 3+ ions increases significantly with the phase transition from the DFP to OPP phase and is attributed to the higher radiative transition rate (281 s -1 ) of the 5 D 0 level of the Eu 3+ ion in the environment with relatively lower symmetry (C 2v ) because of the increase of crystal size. As the structure changes from DFP to OPP, radioluminescence showed tunable color change from red to orange. The Eu 3+ local structure obtained from DFT calculation confirmed the absence of inversion symmetry in the DFP structure, which is consistent with the experimental emission spectra and Stark components. We also elucidated the host to dopant optical energy transfer through density of states calculations. Overall, our current studies present important observations for the GHOE NPs: (i) thermally induced order-disorder phase transition, (ii) change of point group symmetry around Eu 3+ ions in the two phases, (iii) high thermal stability, and (iv) tunability of radioluminescent color. This work provides fundamental understanding of the relationship between the crystal structure and photophysical properties of lanthanide-doped materials and helps design a strategy for advanced optoelectronic materials

PMSG Based Variable-Speed Wind Turbine Generating Systems With Hybrid Energy Storage

Independent activity of a breeze turbine creating framework under fluctuating breeze and variable load conditions is a troublesome assignment. Also, high responsive power request makes it all the more difficult because of the constraint of receptive capacity of the breeze producing framework. A Remote Area Power Supply (RAPS) framework comprising of a Permanent Magnet Synchronous Generator (PMSG), a half breed vitality stockpiling, a dump stack and a mains stack is considered in this task. The cross breed vitality stockpiling comprises of a battery stockpiling and a supercapacitor where both are associated with the DC transport of the RAPS framework. A vitality administration calculation (EMA) is proposed for the half breed vitality stockpiling with a view to enhance the execution of the battery stockpiling. A synchronous condenser is utilized to give receptive power and inertial help to the RAPS framework. By utilizing svpwm system better smoothning and less contortion was seen in the wave shapes. An organized control approach is produced to deal with the dynamic and receptive power streams among the RAPS parts. In such manner, singular controllers for every rap part have been created for compelling administration of the RAPS segments. The proposed technique is fit for accomplishing: a) vigorous voltage and recurrence direction (as far as their adequate data transfer capacities), b) successful administration of the cross breed stockpiling framework, c) receptive power ability and inertial help by the synchronous condenser, and d) most extreme power extraction from wind. The outcomes will be helped out through Matlab/simulink R2009a condition

Roles of oxygen vacancies and pH induced size changes on photo- and radioluminescence of undoped and Eu3+-doped La2Zr2O7 nanoparticles

Defect, doping and particle size play important roles on the optical performance of nanophosphors. In this study, undoped La2Zr2O7 NPs (LZO) displayed multicolor emission under UV irradiation due to the presence of ionized oxygen vacancies in the band gap. In addition, we explored the effect of particle size of La2Zr2O7:Eu3+ (LZOE) NPs on their structure, surface area, photoluminescence, radioluminescence, lifetime and quantum yield. There is progressive decrease in luminescence output and quantum yield as the coprecipitation pH is raised to prepare the single-source precursors for the molten salt synthesis of the NPs. Under X-ray irradiation, the LZOE NPs emit red light highlighting their potential as X-ray scintillator. We explained the experimental observations based on surface defect analogy. The experimentally obtained emission in violet-blue and red optical regions is correlated to defect related emission. High asymmetry ratio suggested low symmetric environment of Eu3+ ions in the LZO host and the occupancy of Eu3+ ions is more favorable at LaO8 site compared to ZrO6 site. Emission spectra of the LZOE also showed favorable host to dopant (Eu3+) energy transfer. This work provides a clear picture of making highly efficient red phosphor and X-ray scintillator for applications in optoelectronics and X-ray induced theranostics

Human-ecodynamics and the intertidal zones of the Zanzibar Archipelago

The intertidal zone, covering the nearshore fringe of coasts and islands and extending from the high-water mark to areas that remain fully submerged, encompasses a range of habitats containing resources that are as important to modern populations as they were to humans in prehistory. Effectively bridging land and sea, intertidal environments are extremely dynamic, requiring complexity and variability in how people engaged with them in the past, much as they do in the present. Here we review and reconsider environmental, archaeological, and modern socio-ecological evidence from the Zanzibar Archipelago on eastern Africa’s Swahili coast, focusing on marine molluscs to gain insight into the trajectories of human engagement with nearshore habitats and resources. We highlight the potential drivers of change and/or stability in human-intertidal interactions through time and space, set against a backdrop of the significant socio-economic and socio-ecological changes apparent in the archipelago, and along the Swahili coast, during the late Holocene.1 Introduction 2 Background 2.1 Unguja and Pemba Islands, Zanzibar Archipelago 2.2 Archaeological and historical overview 2.3 Study site locations, descriptions and chronology 2.3.1 Northern Pemba: Pango la Watoro and Msuka Mjini 2.3.2 Southern Pemba: Ras Mkumbuu 2.3.3 Northern Unguja: Fukuchani and Mvuleni 2.3.4 Southern Unguja: Unguja Ukuu, Kuumbi Cave and Mifupani 2.4 Palaeoenvironmental context 3 Materials and methods 3.1 Identification and abundance 3.2 Richness, nestedness and taxonomic composition 3.3 Diversity indices 3.4 Molluscan zonation and benthic habitat attribution 4 Results 4.1 Assemblage characteristics 4.2 Richness and nestedness 4.3 Taxonomic composition 4.4 Assemblage diversity 4.5 Zonation and benthic habitat analysis 5 Discussion 6 Conclusio

User`s guide and documentation manual for ``BOAST-VHS for the PC``

The recent advancement of computer technology makes reservoir simulations feasible in a personal computer (PC) environment. This manual provides a guide for running BOAST-VHS, a black oil reservoir simulator for vertical/horizontal/slant wells, using a PC. In addition to detailed explanations of input data file preparation for simulation runs, special features of BOAST-VHS are described and three sample problems are presented. BOAST-VHS is a cost-effective and easy-to-use reservoir simulation tool for the study of oil production from primary depletion and waterflooding in a black oil reservoir. The well model in BOAST-VHS permits specification of any combination of horizontal, slanted, and vertical wells in the reservoir. BOAST-VHS was designed for an IBM PC/AT, PS-2, or compatible computer with 640 K bytes of memory. BOAST-VHS can be used to model a three-dimensional reservoir of up to 810 grid blocks with any combination of rows, columns, and layers, depending on the input data supplied. This dynamic redimensioning feature facilitates simulation work by avoiding the need to recompiling the simulator for different reservoir models. Therefore the program is only supplied as executable code without any source code