A Framework for Exploiting Emergent Behaviour to capture 'Best Practice' within a Programming Domain

Inspection is a formalised process for reviewing an artefact in software engineering. It is proven to significantly reduce defects, to ensure that what is delivered is what is required, and that the finished product is effective and robust. Peer code review is a less formal inspection of code, normally classified as inadequate or substandard Inspection. Although it has an increased risk of not locating defects, it has been shown to improve the knowledge and programming skills of its participants. This thesis examines the process of peer code review, comparing it to Inspection, and attempts to describe how an informal code review can improve the knowledge and skills of its participants by deploying an agent oriented approach. During a review the participants discuss defects, recommendations and solutions, or more generally their own experience. It is this instant adaptability to new 11 information that gives the review process the ability to improve knowledge. This observed behaviour can be described as the emergent behaviour of the group of programmers during the review. The wider distribution of knowledge is currently only performed by programmers attending other reviews. To maximise the benefits of peer code review, a mechanism is needed by which the findings from one team can be captured and propagated to other reviews / teams throughout an establishment. A prototype multi-agent system is developed with the aim of capturing the emergent properties of a team of programmers. As the interactions between the team members is unstructured and the information traded is dynamic, a distributed adaptive system is required to provide communication channels for the team and to provide a foundation for the knowledge shared. Software agents are capable of adaptivity and learning. Multi-agent systems are particularly effective at being deployed within distributed architectures and are believed to be able to capture emergent behaviour. The prototype system illustrates that the learning mechanism within the software agents provides a solid foundation upon which the ability to detect defects can be learnt. It also demonstrates that the multi-agent approach is apposite to provide the free flow communication of ideas between programmers, not only to achieve the sharing of defects and solutions but also at a high enough level to capture social information. It is assumed that this social information is a measure of one element of the review process's emergent behaviour. The system is capable of monitoring the team-perceived abilities of programmers, those who are influential on the programming style of others, and the issues upon III which programmers agree or disagree. If the disagreements are classified as unimportant or stylistic issues, can it not therefore be assumed that all agreements are concepts of "Best Practice"? The conclusion is reached that code review is not a substandard Inspection but is in fact complementary to the Inspection model, as the latter improves the process of locating and identifying bugs while the former improves the knowledge and skill of the programmers, and therefore the chance of bugs not being encoded to start with. The prototype system demonstrates that it is possible to capture best practice from a review team and that agents are well suited to the task. The performance criteria of such a system have also been captured. The prototype system has also shown that a reliable level of learning can be attained for a real world task. The innovative way of concurrently deploying multiple agents which use different approaches to achieve the same goal shows remarkable robustness when learning from small example sets. The novel way in which autonomy is promoted within the agents' design but constrained within the agent community allows the system to provide a sufficiently flexible communications structure to capture emergent social behaviour, whilst ensuring that the agents remain committed to their own goals

Parenting a second time around: The strengths and challenges of Indigenous grandparent caregivers

Background: There is a lack of knowledge and research of Indigenous grandparents rearing grandchildren. A burgeoning area of research, the literature only includes studies conducted from the year 2002 and onwards. In order to minimize the burdens that Indigenous grandparents encounter when assuming this role, a greater understanding of this population is crucial. This scoping review was undertaken in an attempt to gain insight into and generate awareness of this population, specifically concerning their needs and experiences. Methods: Sixteen databases were searched, including two medical databases and fourteen social science databases. A total of 92 titles and abstracts were independently reviewed. Of these, 36 full-text articles were retrieved; 31 articles met the inclusion criteria and were reviewed. Findings: Four major themes were identified: (1) The historical context of Indigenous peoples and how this has affected families; (2) The context of caregiving and government policies as they relate to Indigenous grandparents raising their grandchildren; (3) The physical and mental health of the grandparents; and (4) Informal social support

Life History of the Marine Isopod Cyathura polita in the Saint John River Estuary, New Brunswick: a Species at the Northern Extent of its Range

The marine isopod, Cyathura polita, inhabits estuaries on the east coast of North America from the Gulf of Mexico to the Bay of Fundy, Canada. We studied C. polita in the Saint John estuary to test for potential differences in life history that might occur because of the northern location of the population. In the Saint John, based on our interpretation from a six-month sampling program (May-October), the population exhibits a three-year life cycle, one year longer than more southern populations, and stretching over four summers. Our study supported the occurrence of protogynic hermaphroditism. After two summers as juveniles, individuals matured as females during their third summer, then displayed sex reversal by becoming males that fall, and finally reproducing as males in their fourth summer of life before death. Mean length of C. polita from the Saint John was greater than individuals from more southern populations (females, 13.8 ± 2.14 mm; males, 16.3 ± 2.41 mm). Annual brood release occurred in late July-early August. Mean fecundity of females was 53.2 ± 18.9 embryos per brood, which was greater than found in southern populations. Cyathura polita is rare in Canada and is known only from the Saint John and along the northern shore of the Bay of Fundy to the border of the United States

Developing and testing accelerated partner therapy for partner notification for people with genital Chlamydia trachomatis diagnosed in primary care: a pilot randomised controlled trial

Background Accelerated partner therapy (APT) is a promising partner notification (PN) intervention in specialist sexual health clinic attenders. To address its applicability in primary care, we undertook a pilot randomised controlled trial (RCT) of two APT models in community settings. Methods Three-arm pilot RCT of two adjunct APT interventions: APTHotline (telephone assessment of partner(s) plus standard PN) and APTPharmacy (community pharmacist assessment of partner(s) plus routine PN), versus standard PN alone (patient referral). Index patients were women diagnosed with genital chlamydia in 12 general practices and three community contraception and sexual health (CASH) services in London and south coast of England, randomised between 1 September 2011 and 31 July 2013. Results 199 women described 339 male partners, of whom 313 were reported by the index as contactable. The proportions of contactable partners considered treated within 6 weeks of index diagnosis were APTHotline 39/111 (35%), APTPharmacy 46/100 (46%), standard patient referral 46/102 (45%). Among treated partners, 8/39 (21%) in APTHotline arm were treated via hotline and 14/46 (30%) in APTPharmacy arm were treated via pharmacy. Conclusions The two novel primary care APT models were acceptable, feasible, compliant with regulations and capable of achieving acceptable outcomes within a pilot RCT but intervention uptake was low. Although addition of these interventions to standard PN did not result in a difference between arms, overall PN uptake was higher than previously reported in similar settings, probably as a result of introducing a formal evaluation. Recruitment to an individually randomised trial proved challenging and full evaluation will likely require service-level randomisation

Incidence of ischaemic heart disease and stroke among people with psychiatric disorders:retrospective cohort study

Background: Psychiatric disorders are associated with increased risk of ischaemic heart disease (IHD) and stroke, but it is not known whether the associations or the role of sociodemographic factors have changed over time. Aims: To investigate the association between psychiatric disorders and IHD and stroke, by time period and sociodemographic factors. Method: We used Scottish population-based records from 1991 to 2015 to create retrospective cohorts with a hospital record for psychiatric disorders of interest (schizophrenia, bipolar disorder or depression) or no record of hospital admission for mental illness. We estimated incidence and relative risks of IHD and stroke in people with versus without psychiatric disorders by calendar year, age, gender and area-based deprivation level. Results: In all cohorts, incidence of IHD (645 393 events) and stroke (276 073 events) decreased over time, but relative risks decreased for depression only. In 2015, at the mean age at event onset, relative risks were 2- to 2.5-fold higher in people with versus without a psychiatric disorder. Age at incidence of outcome differed by cohort, gender and socioeconomic status. Relative but not absolute risks were generally higher in women than men. Increasing deprivation conveys a greater absolute risk of IHD for people with bipolar disorder or depression. Conclusions: Despite declines in absolute rates of IHD and stroke, relative risks remain high in those with versus without psychiatric disorders. Cardiovascular disease monitoring and prevention approaches may need to be tailored by psychiatric disorder and cardiovascular outcome, and be targeted, for example, by age and deprivation level

Severe mental illness and mortality and coronary revascularisation following a myocardial infarction:a retrospective cohort study

Background: Severe mental illness (SMI), comprising schizophrenia, bipolar disorder and major depression, is associated with higher myocardial infarction (MI) mortality but lower coronary revascularisation rates. Previous studies have largely focused on schizophrenia, with limited information on bipolar disorder and major depression, long-term mortality or the effects of either sociodemographic factors or year of MI. We investigated the associations between SMI and MI prognosis and how these differed by age at MI, sex and year of MI. Methods: We conducted a national retrospective cohort study, including adults with a hospitalised MI in Scotland between 1991 and 2014. We ascertained previous history of schizophrenia, bipolar disorder and major depression from psychiatric and general hospital admission records. We used logistic regression to obtain odds ratios adjusted for sociodemographic factors for 30-day, 1-year and 5-year mortality, comparing people with each SMI to a comparison group without a prior hospital record for any mental health condition. We used Cox regression to analyse coronary revascularisation within 30 days, risk of further MI and further vascular events (MI or stroke). We investigated associations for interaction with age at MI, sex and year of MI. Results: Among 235,310 people with MI, 923 (0.4%) had schizophrenia, 642 (0.3%) had bipolar disorder and 6239 (2.7%) had major depression. SMI was associated with higher 30-day, 1-year and 5-year mortality and risk of further MI and stroke. Thirty-day mortality was higher for schizophrenia (OR 1.95, 95% CI 1.64–2.30), bipolar disorder (OR 1.53, 95% CI 1.26–1.86) and major depression (OR 1.31, 95% CI 1.23–1.40). Odds ratios for 1-year and 5-year mortality were larger for all three conditions. Revascularisation rates were lower in schizophrenia (HR 0.57, 95% CI 0.48–0.67), bipolar disorder (HR 0.69, 95% CI 0.56–0.85) and major depression (HR 0.78, 95% CI 0.73–0.83). Mortality and revascularisation disparities persisted from 1991 to 2014, with absolute mortality disparities more apparent for MIs that occurred around 70 years of age, the overall mean age of MI. Women with major depression had a greater reduction in revascularisation than men with major depression. Conclusions: There are sustained SMI disparities in MI intervention and prognosis. There is an urgent need to understand and tackle the reasons for these disparities

Communication in Undergraduate Science - What are we doing?

BACKGROUND Communication is a ubiquitous graduate attribute and learning outcome for undergraduate science degrees across the world and an invaluable tool for students to demonstrate their learning. Most vocation-focussed science degrees, such as engineering and health professions, articulate clear, highly specific communication outcomes for students that are informed by feedback from industry groups. These outcomes combined with best practice within the profession help to guide the design and implementation of student learning activities. General science degrees, such as a Bachelor of Science, have neither clear, specific goals nor feedback from specific industry groups. A valuable start has been made to guide good practice in educating undergraduate science students in the TLO4: Communication (Colthorpe, Rowland & Leach, 2013). However, there is little evidence available as to what aspects of communication are currently taught in a science context, and detailed discussions have not yet been had as to what elements of communication are most relevant for modern undergraduate science students to learn. This presentation will bring these two topics into focus by reporting on preliminary research findings to help stimulate and garner momentum for clarity and change around the education of undergraduate science students in communication. AIMS 1. Quantify the proportion and types of communication-style assessment tasks in the Bachelor of Science program (across all majors) at research-intensive universities. 2. Review and critique existing literature on what constitutes effective science communication. DESIGN AND METHODS 1. Data for 1500 units of study (e.g., courses) assessment tasks were collected from profiles publicly available on university websites from five research-intensive Go8 in 2012/2013. Assessment tasks were categorised as “exam”, “communication” or “other”. “Communication” assessment tasks across 8 majors were categorised according to audience, medium and purpose. 2. Over 25 relevant published articles, mostly peer-reviewed, from the disciplines of science, communication and science communication were reviewed and critiqued according to research methodology and relevance to undergraduate education. RESULTS Communication style assessment tasks constituted about 20-30% of assessment in BSc programs, with the exception of mathematics

Is chlamydia screening and testing in Britain reaching young adults at risk of infection? Findings from the third National Survey of Sexual Attitudes and Lifestyles (Natsal-3).

BACKGROUND: In the context of widespread opportunistic chlamydia screening among young adults, we aimed to quantify chlamydia testing and diagnosis among 16-24 year olds in Britain in relation to risk factors for prevalent chlamydia infection. METHODS: Using data from sexually experienced (≥1 lifetime sexual partner) 16-year-old to 24-year-old participants in Britain's third National Survey of Sexual Attitudes and Lifestyles (conducted 2010-2012), we explored socio-demographic and behavioural factors associated with prevalent chlamydia infection (detected in urine; n=1832), self-reported testing and self-reported diagnosis in the last year (both n=3115). RESULTS: Chlamydia prevalence was 3.1% (95% CI 2.2% to 4.3%) in women and 2.3% (1.5% to 3.4%) in men. A total of 12.3% of women and 5.3% men had a previous chlamydia diagnosis. Factors associated with prevalent infection were also associated with testing and diagnosis (eg, increasing numbers of sexual partners), with some exceptions. For example, chlamydia prevalence was higher in women living in more deprived areas, whereas testing was not. In men, prevalence was higher in 20-24 than 16-19 year olds but testing was lower. Thirty per cent of women and 53.7% of men with ≥2 new sexual partners in the last year had not recently tested. CONCLUSIONS: In 2010-2012 in Britain, the proportion of young adults reporting chlamydia testing was generally higher in those reporting factors associated with chlamydia. However, many of those with risk factors had not been recently tested, leaving potential for undiagnosed infections. Greater screening and prevention efforts among individuals in deprived areas and those reporting risk factors for chlamydia may reduce undiagnosed prevalence and transmission

Incidence of type 2 diabetes in people with a history of hospitalisation for major mental illness in Scotland 2001-2015: a retrospective cohort study

Objective: To determine the incidence of type 2 diabetes in people with a history of hospitalization for major mental illness versus no mental illness in Scotland by time period and sociodemographics. Research Design and Methods: We used national Scottish population-based records to create cohorts with a hospital record of schizophrenia, bipolar disorder, or depression or no mental illness and to ascertain diabetes incidence. We used quasi-Poisson regression models including age, sex, time period, and area-based deprivation to estimate incidence and relative risks (RRs) of diabetes by mental illness status. Estimates are illustrated for people aged 60 years and in the middle deprivation quintile in 2015. Results: We identified 254,136 diabetes cases during 2001–2015. Diabetes incidence in 2015 was 1.5- to 2.5-fold higher in people with versus without a major mental disorder, with the gap having slightly increased over time. RRs of diabetes incidence were greater among women than men for schizophrenia (RR 2.40 [95% CI 2.01, 2.85] and 1.63 [1.38, 1.94]), respectively) and depression (RR 2.10 [1.86, 2.36] and 1.62 [1.43, 1.82]) but similar for bipolar disorder (RR 1.65 [1.35, 2.02] and 1.50 [1.22, 1.84]). Absolute and relative differences in diabetes incidence associated with mental illness increased with increasing deprivation. Conclusions: Disparities in diabetes incidence between people with and without major mental illness appear to be widening. Major mental illness has a greater effect on diabetes risk in women and people living in more deprived areas, which has implications for intervention strategies to reduce diabetes risk in this vulnerable population

Epidemiology of Mycoplasma genitalium in British men and women aged 16–44 years: evidence from the third National Survey of Sexual Attitudes and Lifestyles (Natsal-3).

BACKGROUND: There are currently no large general population epidemiological studies of Mycoplasma genitalium (MG), which include prevalence, risk factors, symptoms and co-infection in men and women across a broad age range. METHODS: In 2010-–12, we conducted the third National Survey of Sexual Attitudes and Lifestyles (Natsal-3), a probability sample survey in Britain. Urine from 4507 sexually-experienced participants, aged 16–44 years, was tested for MG. RESULTS: MG prevalence was 1.2% [95% confidence interval (CI): 0.7–1.8%] in men and 1.3% (0.9–1.9%) in women. There were no positive MG tests in men aged 16–19, and prevalence peaked at 2.1% (1.2–3.7%) in men aged 25–34 years. In women, prevalence was highest in 16–19 year olds, at 2.4% (1.2–4.8%), and decreased with age. Men of Black ethnicity were more likely to test positive for MG [adjusted odds ratio (AOR) 12.1; 95% CI: 3.7–39.4). For both men and women, MG was strongly associated with reporting sexual risk behaviours (increasing number of total and new partners, and unsafe sex, in the past year). Women with MG were more likely to report post-coital bleeding (AOR 5.8; 95%CI 1.4–23.3). However, the majority of men (94.4%), and over half of women (56.2%) with MG did not report any sexually transmitted infection (STI) symptoms. Men with MG were more likely to report previously diagnosed gonorrhoea, syphilis or non-specific urethritis, and women previous trichomoniasis. CONCLUSIONS: This study strengthens evidence that MG is an STI. MG was identified in over 1% of the population, including in men with high-risk behaviours in older age groups that are often not included in STI prevention measures