The Dwarfs Beyond: The Stellar-to-Halo Mass Relation for a New Sample of Intermediate Redshift Low Mass Galaxies

A number of recent challenges to the standard Lambda-CDM paradigm relate to discrepancies that arise in comparing the abundance and kinematics of local dwarf galaxies with the predictions of numerical simulations. Such arguments rely heavily on the assumption that the local dwarf and satellite galaxies form a representative distribution in terms of their stellar-to-halo mass ratios. To address this question, we present new, deep spectroscopy using DEIMOS on Keck for 82 low mass (10^7-10^9 solar masses) star-forming galaxies at intermediate redshift (z=0.2-1). For 50 percent of these we are able to determine resolved rotation curves using nebular emission lines and thereby construct the stellar mass Tully-Fisher relation to masses as low as 10^7 solar masses. Using scaling relations determined from weak lensing data, we convert this to a stellar-to-halo mass (SHM) relation for comparison with abundance matching predictions. We find a discrepancy between the propagated predictions from simulations compared to our observations, and suggest possible reasons for this as well as future tests that will be more effective.Comment: 11 pages, 7 figures, submitted to ApJ, comments welcom

Molecular profiling of resident and infiltrating mononuclear phagocytes during rapid adult retinal degeneration using single-cell RNA sequencing.

Neuroinflammation commonly accompanies neurodegeneration, but the specific roles of resident and infiltrating immune cells during degeneration remains controversial. Much of the difficulty in assessing myeloid cell-specific functions during disease progression arises from the inability to clearly distinguish between activated microglia and bone marrow-derived monocytes and macrophages in various stages of differentiation and activation within the central nervous system. Using an inducible model of photoreceptor cell death, we investigated the prevalence of infiltrating monocytes and macrophage subpopulations after the initiation of degeneration in the mouse retina. In vivo retinal imaging revealed infiltration of CCR2+ leukocytes across retinal vessels and into the parenchyma within 48 hours of photoreceptor degeneration. Immunohistochemistry and flow cytometry confirmed and characterized these leukocytes as CD11b+CD45+ cells. Single-cell mRNA sequencing of the entire CD11b+CD45+ population revealed the presence of resting microglia, activated microglia, monocytes, and macrophages as well as 12 distinct subpopulations within these four major cell classes. Our results demonstrate a previously immeasurable degree of molecular heterogeneity in the innate immune response to cell-autonomous degeneration within the central nervous system and highlight the necessity of unbiased high-throughput and high-dimensional molecular techniques like scRNAseq to understand the complex and changing landscape of immune responders during disease progression

Who Are the “Journalism Kids?” Academic Predictors of Journalism Participation in Secondary Schools

Prior scholastic journalism research did not adequately address the possibility that journalism students perform better academically because of their backgrounds and inherent abilities. Using Education Longitudinal Study of 2002 data, this study shows that high school journalism attracts better students. Although for-credit and extracurricular programs differentiate journalism student characteristics, journalism students generally tend to have greater English self-efficacy, higher English grade point average, greater involvement in schools, be female and White, or have a higher socioeconomic background than those who do not participate in journalism. Future assessments of journalism’s contribution to academic achievement should account for students’ pre-journalism characteristics

Protective actions of des-acylated ghrelin on brain injury and blood-brain barrier disruption after stroke in mice

The major ghrelin forms, acylated ghrelin and des-acylated ghrelin, are novel gastrointestinal hormones. Moreover, emerging evidence indicates that these peptides may have other functions including neuro- and vaso-protection. Here, we investigated whether post-stroke treatment with acylated ghrelin or des-acylated ghrelin could improve functional and histological endpoints of stroke outcome in mice after transient middle cerebral artery occlusion (tMCAo). We found that des-acylated ghrelin (1 mg/kg) improved neurological and functional performance, reduced infarct and swelling, and decreased apoptosis. In addition, it reduced blood-brain barrier (BBB) disruption in vivo and attenuated the hyper-permeability of mouse cerebral microvascular endothelial cells after oxygen glucose deprivation and reoxygenation (OGD + RO). By contrast, acylated ghrelin (1 mg/kg or 5 mg/kg) had no significant effect on these endpoints of stroke outcome. Next we found that des-acylated ghrelin's vasoprotective actions were associated with increased expression of tight junction proteins (occludin and claudin-5), and decreased cell death. Moreover, it attenuated superoxide production, Nox activity and expression of 3-nitrotyrosine. Collectively, these results demonstrate that post-stroke treatment with des-acylated ghrelin, but not acylated ghrelin, protects against ischaemia/reperfusion-induced brain injury and swelling, and BBB disruption, by reducing oxidative and/or nitrosative damage

The Assembly History of Disk Galaxies: II. Probing the Emerging Tully-Fisher Relation During 1<z<1.7

Through extended integrations using the recently-installed deep depletion CCD on the red arm of the Keck I Low Resolution Imaging Spectrograph, we present new measurements of the resolved spectra of 70 morphologically-selected star-forming galaxies with i_AB<24.1 in the redshift range 1<z<1.7. Using the formalism introduced in Paper I of this series and available HST ACS images, we successfully recover rotation curves using the extended emission line distribution of [O II] 3727 A to 2.2 times the disk scale radius for a sample of 42 galaxies. Combining these measures with stellar masses derived from HST and ground-based near-infrared photometry enables us to construct the stellar mass Tully-Fisher relation in the time interval between the well-constructed relation defined at z~1 in Paper I and the growing body of resolved dynamics probed with integral field unit spectrographs at z>2. Remarkably, we find a well-defined Tully-Fisher relation with up to 60% increase in scatter and stellar mass zero-point shift constraint of 0.02+/-0.02 dex since z~1.7, compared to the local relation. Although our sample is incomplete in terms of either a fixed stellar mass or star formation rate limit, we discuss the implications that typical star-forming disk galaxies evolve to arrive on a well-defined Tully-Fisher relation within a surprisingly short period of cosmic history.Comment: 13 pages, 8 figures, accepted for publication at Ap

Have Gender Gaps in Math Closed? Achievement, Teacher Perceptions, and Learning Behaviors Across Two ECLS-K Cohorts

Studies using data from the Early Childhood Longitudinal Study–Kindergarten Class of 1998–1999 (ECLS-K:1999) revealed gender gaps in mathematics achievement and teacher perceptions. However, recent evidence suggests that gender gaps have closed on state tests, raising the question of whether such gaps are absent in the ECLS-K:2011 cohort. Extending earlier analyses, this study compares the two ECLS-K cohorts, exploring gaps throughout the achievement distribution and examining whether learning behaviors might differentially explain gaps more at the bottom than the top of the distribution. Overall, this study reveals remarkable consistency across both ECLS-K cohorts, with the gender gap developing early among high achievers and spreading quickly throughout the distribution. Teachers consistently rate girls’ mathematical proficiency lower than that of boys with similar achievement and learning behaviors. Gender differences in learning approaches appear to be fairly consistent across the achievement distribution, but girls’ more studious approaches appear to have more payoff at the bottom of the distribution than at the top. Questions remain regarding why boys outperform girls at the top of the distribution, and several hypotheses are discussed. Overall, the persistent ECLS-K patterns make clear that girls’ early mathematics learning experiences merit further attention

The Potential Trajectory of Carbapenem-Resistant Enterobacteriaceae, an Emerging Threat to Health-Care Facilities, and the Impact of the Centers for Disease Control and Prevention Toolkit.

Carbapenem-resistant Enterobacteriaceae (CRE), a group of pathogens resistant to most antibiotics and associated with high mortality, are a rising emerging public health threat. Current approaches to infection control and prevention have not been adequate to prevent spread. An important but unproven approach is to have hospitals in a region coordinate surveillance and infection control measures. Using our Regional Healthcare Ecosystem Analyst (RHEA) simulation model and detailed Orange County, California, patient-level data on adult inpatient hospital and nursing home admissions (2011-2012), we simulated the spread of CRE throughout Orange County health-care facilities under 3 scenarios: no specific control measures, facility-level infection control efforts (uncoordinated control measures), and a coordinated regional effort. Aggressive uncoordinated and coordinated approaches were highly similar, averting 2,976 and 2,789 CRE transmission events, respectively (72.2% and 77.0% of transmission events), by year 5. With moderate control measures, coordinated regional control resulted in 21.3% more averted cases (n = 408) than did uncoordinated control at year 5. Our model suggests that without increased infection control approaches, CRE would become endemic in nearly all Orange County health-care facilities within 10 years. While implementing the interventions in the Centers for Disease Control and Prevention's CRE toolkit would not completely stop the spread of CRE, it would cut its spread substantially, by half

Sentinel Case of Candida auris in the Western United States Following Prolonged Occult Colonization in a Returned Traveler from India.

Candida auris is an emerging multidrug-resistant yeast with high mortality. We report the sentinel C. auris case on the United States West Coast in a patient who relocated from India. We identified close phylogenetic relatedness to the South Asia clade and ERG11 Y132F and FKS1 S639Y mutations potentially explaining antifungal resistance