Silika İle Güçlendirilmiş Maksillofasiyal Silikon Elastomerlerin Fiziksel Özelliklerinin Değerlendirilmesi

Amaç: Yüz protezi uygulamalarında kullanılan silikon elastomerlerde karşılaşılan en büyük problemlerden biri özellikle protez kenarlarda meydana gelen yırtılmalar ve bu sebeple protezin yenilenme ihtiyacıdır. Çalışmanın amacı silikon elastomerleri güçlendirmede kullanılan silikanın farklı oranlarda ilavesinin fiziksel özelliklere etkisini değerlendirmektir.     Gereç ve Yöntem: Çalışmada, silikon elastomerlere %10, 20 ve 30 oranında silika ilave edildi. Daha sonra çekme direnci, uzama yüzdesi, yırtılma direnci ve sertlik değerleri ölçüldü. Çalışma verileri değerlendirilirken niceliksel verilerin karşılaştırılmasında tekrarlayan ölçümlerde varyans analizi ve anlamlılığa neden olan ölçümün tespitinde Post-Hoc Bonferroni Test kullanıldı. Anlamlılık p<0.05 düzeyinde değerlendirildi.     Bulgular: Çekme direnci en yüksek olarak %20 oranında silika ilave edildiğinde gözlendi. Uzama oranı ise en fazla saf silikonda ve bunu takiben %10’luk silika ilavesinde görüldü. Yırtılma direnci en fazla %30 silika ilaveli silikonda gözlendi. Bununla beraber sertlik de en fazla bu oranda izlendi.                Sonuç: Silikon elastomerlerine %20’lik silika ilavesi malzemenin mukavemetini pozitif yönde etkilemektedir. Bunun üzerindeki oranlarda yapılan ilavenin yapıyı bozduğu görülmüştür. &nbsp

Impact of Electrical Stimulation on Rehabilitation Process in Peripheral Facial Paralysis

Aim: The purpose of this study is to discuss the efficiency of electrical stimulation in the treatment of facial paralysis, and its contribution to the rehabilitation process and, its impact on recovery. Material and methods: 18 cases were enrolled into the study who were diagnosed with ficial paralysis and consulted within the first month, and have been receiving medical treatment. Home exercise program was given to all patients. The first group was followed-up with hospital rehabilitation program that included electrical stimulation, while the second group was organized to recieve only home exercise program. Functional response to treatment was assessed by the House-Brackmann scale grading system. Results: House-Brackmann scale scores of rehabilitation program and electrical stimulation patient group, were compared pre-and post-treatment, clinical improvement was observed more significantly in the 6th week. There. was no significant difference between House-Brackmann scale scores in pre-treatment and the 69 week visits of the patients in home exercise program group (p = 0.16). However, the Houser-Brackmann scale scores were detected to be statistically significantly different between pre-and 6 months after the treatment in both of the treatment groups (p = 0.005). Conclusion: As a result, the recovery time is faster in the patients treated with the rehabilitation group that includes electrical stimulation. Therefore electrical stimulation therapy is an acceptable effective method for the treatment of facial paralysis, nonetheless this should be investigated in larger patient groups, in future

Osteoprotegerin, leptin and IL-6: Association with silent myocardial ischemia in type 2 diabetes mellitus

Background: Diabetic patients often exhibit severe, asymptomatic coronary artery disease (CAD). The relationship between osteoprotegerin (OPG), inflammatory markers and silent myocardial ischemia remains to be elucidated. Methods: We recruited 45 type 2 diabetic patients and 33 healthy controls and assessed them for silent myocardial ischemia (SMI) by myocardial perfusion imaging. Patient blood was tested for OPG, IL-6 and leptin concentrations. Results: OPG, leptin and IL-6 levels were found significantly elevated in diabetic patients (p < 0.001, p < 0.01, p < 0.05). Based on our classification of presence/absence of SMI in our diabetic group, we found that there was a significant association between SMI and the biomarkers IL-6 (p <0.001), leptin (p<0.001) and OPG (p <0.05). In multivariate regression analyses, OPG was found to be significantly related to diabetes mellitus and to SMI. Age, sex and smoking increased the association between OPG and SMI

Yaşlı osteoporotik kadınlarda zoledronik asit uygulaması sonrası kalp ritmi takip edilmeli midir?]

Objectives: This study aims to investigate the possible undesirable cardiac effects associated with zoledronic acid treatment in elderly osteoporotic women. Patients and methods: Between October 2010 and December 2013, a total of 33 osteoporotic female patients (mean age 73.3 +/- 6.9 years; range 65 to 85 years) were included in this prospective study. Bone mineral density of the patients was measured. Biochemical and hormonal analyzes were performed. Electrocardiograms were taken. These analyses were repeated twice at one hour and 10 days after the administration of the zoledronic acid. Results: Pre- and post-treatment electrocardiography findings within the first hour were found to be within normal limits. P-wave dispersion and RR intervals, which were found to be normal before administration of the drug, tended to significantly increase at 10 days following the administration (p=0.029 and p=0.031, respectively). Using a cut-off value of 50 msec, alterations in corrected QT dispersion were found to be statistically significant (p=0.004). Conclusion: Based on our study findings, an increased ventricular arrhythmia risk should be also possibly considered as well as well-known atrial arrhythmic adverse effects of zoledronic acid. Therefore, we recommend a thorough examination for cardiac arrhythmia before the drug administration

Osteoprotegerin, leptin and IL-6: Association with silent myocardial ischemia in type 2 diabetes mellitus

Background: Diabetic patients often exhibit severe, asymptomatic coronary artery disease (CAD). The relationship between osteoprotegerin (OPG), inflammatory markers and silent myocardial ischemia remains to be elucidated. Methods: We recruited 45 type 2 diabetic patients and 33 healthy controls and assessed them for silent myocardial ischemia (SMI) by myocardial perfusion imaging. Patient blood was tested for OPG, IL-6 and leptin concentrations. Results: OPG, leptin and IL-6 levels were found significantly elevated in diabetic patients (p < 0.001, p < 0.01, p < 0.05). Based on our classification of presence/absence of SMI in our diabetic group, we found that there was a significant association between SMI and the biomarkers IL-6 (p <0.001), leptin (p<0.001) and OPG (p <0.05). In multivariate regression analyses, OPG was found to be significantly related to diabetes mellitus and to SMI. Age, sex and smoking increased the association between OPG and SMI. Conclusion: High OPG, leptin and IL-6 levels are associated with the presence and severity of SMI in type 2 diabetic patients

Impact of the COVID-19 pandemic on patients with paediatric cancer in low-income, middle-income and high-income countries: a multicentre, international, observational cohort study

OBJECTIVES: Paediatric cancer is a leading cause of death for children. Children in low-income and middle-income countries (LMICs) were four times more likely to die than children in high-income countries (HICs). This study aimed to test the hypothesis that the COVID-19 pandemic had affected the delivery of healthcare services worldwide, and exacerbated the disparity in paediatric cancer outcomes between LMICs and HICs. DESIGN: A multicentre, international, collaborative cohort study. SETTING: 91 hospitals and cancer centres in 39 countries providing cancer treatment to paediatric patients between March and December 2020. PARTICIPANTS: Patients were included if they were under the age of 18 years, and newly diagnosed with or undergoing active cancer treatment for Acute lymphoblastic leukaemia, non-Hodgkin's lymphoma, Hodgkin lymphoma, Wilms' tumour, sarcoma, retinoblastoma, gliomas, medulloblastomas or neuroblastomas, in keeping with the WHO Global Initiative for Childhood Cancer. MAIN OUTCOME MEASURE: All-cause mortality at 30 days and 90 days. RESULTS: 1660 patients were recruited. 219 children had changes to their treatment due to the pandemic. Patients in LMICs were primarily affected (n=182/219, 83.1%). Relative to patients with paediatric cancer in HICs, patients with paediatric cancer in LMICs had 12.1 (95% CI 2.93 to 50.3) and 7.9 (95% CI 3.2 to 19.7) times the odds of death at 30 days and 90 days, respectively, after presentation during the COVID-19 pandemic (p<0.001). After adjusting for confounders, patients with paediatric cancer in LMICs had 15.6 (95% CI 3.7 to 65.8) times the odds of death at 30 days (p<0.001). CONCLUSIONS: The COVID-19 pandemic has affected paediatric oncology service provision. It has disproportionately affected patients in LMICs, highlighting and compounding existing disparities in healthcare systems globally that need addressing urgently. However, many patients with paediatric cancer continued to receive their normal standard of care. This speaks to the adaptability and resilience of healthcare systems and healthcare workers globally

Twelve-month observational study of children with cancer in 41 countries during the COVID-19 pandemic

Childhood cancer is a leading cause of death. It is unclear whether the COVID-19 pandemic has impacted childhood cancer mortality. In this study, we aimed to establish all-cause mortality rates for childhood cancers during the COVID-19 pandemic and determine the factors associated with mortality