Integrated payload and mission planning, phase 3. Volume 1: Integrated payload and mission planning process evaluation

The integrated payload and mission planning process for STS payloads was defined, and discrete tasks which evaluate performance and support initial implementation of this process were conducted. The scope of activity was limited to NASA and NASA-related payload missions only. The integrated payload and mission planning process was defined in detail, including all related interfaces and scheduling requirements. Related to the payload mission planning process, a methodology for assessing early Spacelab mission manager assignment schedules was defined

Prospectus, November 18, 1981

HOSPITALS RECRUIT STUDENTS; News In Brief; Reserve courses early; Thanksgiving first celebrated in 1619; Zappa will perform; Interested in socializing?; Lonely on Thanksgiving? Urbana High offers dinner; Hiring a whole graduating class; P.C. Happ\u27nin\u27s: EMT workshop meets Dec. 5, Print display set, Club holds Western contest, Raffle drawing is Nov. 24, Judging team competes Nov. 20, Pizza sale Nov. 30, Humane society asks donations, Kick the habit Nov. 19, Award Winning film showing; Antigone is an inspirational play; Classifieds; Borge: fool that is loved; ICC takes VB tourney; Sports Notes; BB starts Sat.; Fast Freddy Contest; Entertainment scheduled for break; Freddy misses pro games; Cobras end season; Runners get personal bestshttps://spark.parkland.edu/prospectus_1981/1004/thumbnail.jp

Prospectus, November 25, 1981

INTERCOM TO BE AVAILABLE IN SPRING; News In Brief; Happy Thanksgiving; Should radio be aired in lounge?; President Reagan\u27s cuts in federal aid hurting students; Radiation detection device purchased; Music groups to perform two Christmas programs; Stores set holiday hours; Expect normal winter; Child-rearing serious business; P.C. Happ\u27nin\u27s: PC basketball on WPCD. Social hours set for women, Ski trips planned, Women, myths are topics, Blood donors thanked, PATH suggests fire precautions, PATH sponsors pizza sale; Foreigner: band that\u27s seen changes; Coldstream Guards performed well; Earth Wind and Fire coming to Assembly Hall; Invitational basketball tournament highlights captured; Classifieds; Zappa concert leaves reviewer unimpressed; Cobras even record; Rodney Jones wins Fast Freddy; Fast Freddy Contest; Parkland\u27s 1981-82 men\u27s basketball squad; Problems snowball at weekend volleyball tournamenthttps://spark.parkland.edu/prospectus_1981/1003/thumbnail.jp

Effects of engineered silver nanoparticles on the growth and activity of ecologically important microbes

Summary: Currently, little is known about the impact of silver nanoparticles (AgNPs) on ecologically important microorganisms such as ammonia-oxidizing bacteria (AOB). We performed a multi-analytical approach to demonstrate the effects of uncapped nanosilver (uAgNP), capped nanosilver (cAgNP) and Ag2SO4 on the activities of the AOB: Nitrosomonas europaea, Nitrosospira multiformis and Nitrosococcus oceani, and the growth of Escherichia coli and Bacillus subtilis as model bacterial systems in relation to AgNP type and concentration. All Ag treatments caused significant inhibition to the nitrification potential rates (NPRs) of Nitrosomonas europaea (decreased from 34 to cAgNP>uAgNP. In conclusion, AgNPs (especially cAgNPs) and Ag2SO4 adversely affected AOB activities and thus have the potential to severely impact key microbially driven processes such as nitrification in the environment

Prospectus, October 28, 1981

SENIORS VISIT PARKLAND; News In Brief; Donate blood--help others: One that was helped; Gazette to go electronic; Get on P.C. blood donor team; Images: students at creative best; Homecoming idea conceived by 2 bored men; Western look phasing out; \u27Antigone\u27 opens Nov. 12; County moves to METCAD; Spend year abroad, see Scandinavia; Be safe on Halloween; Stories welcome; P.C. Happ\u27nin\u27s: Ski club plans finances, Prayers offered, EMT workshop set, Model ships presented, CHI sponsors program, Encouraging parents, Stugo discusses food; Chief Illiniwek -- Part of Illini tradition; Moody Blues: classic; Halloween hits early; Willie Nesbit wins Freddy contest; Sports Notes; Girls open at Sugar Grove; Illini football pleases fan; Fast Freddy Contest; Correction; \u27Gallipoli\u27 deals with war, friendship, death; Classifieds; Duvall stars in \u27Confessions\u27; \u27Marbles\u27: nice surprise; Library plans A-V Week; Laugh at \u27Merlin\u27https://spark.parkland.edu/prospectus_1981/1007/thumbnail.jp

Prospectus, December 9, 1981

BOARD DISCUSSES POSSIBLE TUITION RISE; News In Brief; Music groups plan Christmas shows; Debating the radio issue; StuGo asks opinions; Students voice conflicting views; Data Processing sends you grades; Workshop focuses on buisness; Court ruling not hurting sales: Video recorders selling well; Call in your favorite carol Dec. 12; Scholarships awarded for many different reasons; P.C. Happ\u27nin\u27s: PATH says thanks, Parkland team wins honors, Ski trip Jan. 3-8, PATH suggests fire precautions, Final Exam Schedule -- Fall \u2781; Christie Foundation offered free testing; Classifieds; Foreigner thrills crowd; Despite changes, Grateful Dead lives; \u27Rockabilly\u27 movement revives; It\u27s time for college bowl games; Upsets throw off Fast Freddy picks; Parkland women defeat Illinois Wesleyan; ICC places sixth nationally; Fast Freddy Contest; 2 named to Conference; Men drop three in a row...; ...return home again Friday; \u27Absence of Malice\u27 filled with suspense; Carly Simon: Every girl\u27s dreamhttps://spark.parkland.edu/prospectus_1981/1001/thumbnail.jp

Genetic testing of children for adult-onset conditions: opinions of the British adult population and implications for clinical practice

This study set out to explore the attitudes of a representative sample of the British public towards genetic testing in children to predict disease in the future. We sought opinions about genetic testing for adult-onset conditions for which no prevention/treatment is available during childhood, and about genetic 'carrier' status to assess future reproductive risks. The study also examined participants' level of agreement with the reasons professional organisations give in favour of deferring such testing. Participants (n=2998) completed a specially designed questionnaire, distributed by email. Nearly half of the sample (47%) agreed that parents should be able to test their child for adult-onset conditions, even if there is no treatment or prevention at time of testing. This runs contrary to professional guidance about genetic testing in children. Testing for carrier status was supported by a larger proportion (60%). A child's future ability to decide for her/himself if and when to be tested was the least supported argument in favour of deferring testing.European Journal of Human Genetics advance online publication, 5 November 2014; doi:10.1038/ejhg.2014.221

Prospectus, October 7, 1981

BOB BROWN, 55, DIES; News In Brief; Library open until 10 p.m.; Students play in tourneys; Christian Fellowship plans month; Guides needed; Honor society seeks students; Ski Club plans trips; Editor wonders…: Are you alive, Parkland?; PACT programs held; Artist presents workshop; Club selling hot dogs; More tips on shopping; Workshop offered on business; Classifieds; Song simple, yet good; Dunaway stars in new movie; \u27Journey\u27 not worth trip; Talk, learn through your TV in future; PATH holds meeting; Teacher market opening up; Skater returns, playing Tuesday; Children as thieves?: Even kids are dishonest; Golf team wins conference; VB team gives erratic show; Hearns/Leonard fight is reviewed; Sports Notes; Explore the humanities; Fast Freddy is back again; Fast Freddy Contest; Music offers something for everyonehttps://spark.parkland.edu/prospectus_1981/1010/thumbnail.jp

Mutant Huntingtin Fragments Form Oligomers in a Polyglutamine Length-Dependent Manner \u3cem\u3ein Vitro\u3c/em\u3e and \u3cem\u3ein Vivo\u3c/em\u3e

Huntington disease (HD) is caused by an expansion of more than 35–40 polyglutamine (polyQ) repeats in the huntingtin (htt) protein, resulting in accumulation of inclusion bodies containing fibrillar deposits of mutant htt fragments. Intriguingly, polyQ length is directly proportional to the propensity for htt to form fibrils and the severity of HD and is inversely correlated with age of onset. Although the structural basis for htt toxicity is unclear, the formation, abundance, and/or persistence of toxic conformers mediating neuronal dysfunction and degeneration in HD must also depend on polyQ length. Here we used atomic force microscopy to demonstrate mutant htt fragments and synthetic polyQ peptides form oligomers in a polyQ length-dependent manner. By time-lapse atomic force microscopy, oligomers form before fibrils, are transient in nature, and are occasionally direct precursors to fibrils. However, the vast majority of fibrils appear to form by monomer addition coinciding with the disappearance of oligomers. Thus, oligomers must undergo a major structural transition preceding fibril formation. In an immortalized striatal cell line and in brain homogenates from a mouse model of HD, a mutant htt fragment formed oligomers in a polyQ length-dependent manner that were similar in size to those formed in vitro, although these structures accumulated over time in vivo. Finally, using immunoelectron microscopy, we detected oligomeric-like structures in human HD brains. These results demonstrate that oligomer formation by a mutant htt fragment is strongly polyQ length-dependent in vitro and in vivo, consistent with a causative role for these structures, or subsets of these structures, in HD pathogenesis

Appearance Sharing for Collective Human Pose Estimation

Abstract. While human pose estimation (HPE) techniques usually process each test image independently, in real applications images come in collections containing interdependent images. Often several images have similar backgrounds or show persons wearing similar clothing (foreground). We present a novel human pose estimation technique to exploit these dependencies by sharing appearance models between images. Our technique automatically determines which images in the collection should share appearance. We extend the state-of-the art HPE model of Yang and Ramanan to include our novel appearance sharing cues and demonstrate on the highly challenging Leeds Sports Poses dataset that they lead to better results than traditional single-image pose estimation.