Prospectus, November 18, 1981

HOSPITALS RECRUIT STUDENTS; News In Brief; Reserve courses early; Thanksgiving first celebrated in 1619; Zappa will perform; Interested in socializing?; Lonely on Thanksgiving? Urbana High offers dinner; Hiring a whole graduating class; P.C. Happ\u27nin\u27s: EMT workshop meets Dec. 5, Print display set, Club holds Western contest, Raffle drawing is Nov. 24, Judging team competes Nov. 20, Pizza sale Nov. 30, Humane society asks donations, Kick the habit Nov. 19, Award Winning film showing; Antigone is an inspirational play; Classifieds; Borge: fool that is loved; ICC takes VB tourney; Sports Notes; BB starts Sat.; Fast Freddy Contest; Entertainment scheduled for break; Freddy misses pro games; Cobras end season; Runners get personal bestshttps://spark.parkland.edu/prospectus_1981/1004/thumbnail.jp

Prospectus, November 25, 1981

INTERCOM TO BE AVAILABLE IN SPRING; News In Brief; Happy Thanksgiving; Should radio be aired in lounge?; President Reagan\u27s cuts in federal aid hurting students; Radiation detection device purchased; Music groups to perform two Christmas programs; Stores set holiday hours; Expect normal winter; Child-rearing serious business; P.C. Happ\u27nin\u27s: PC basketball on WPCD. Social hours set for women, Ski trips planned, Women, myths are topics, Blood donors thanked, PATH suggests fire precautions, PATH sponsors pizza sale; Foreigner: band that\u27s seen changes; Coldstream Guards performed well; Earth Wind and Fire coming to Assembly Hall; Invitational basketball tournament highlights captured; Classifieds; Zappa concert leaves reviewer unimpressed; Cobras even record; Rodney Jones wins Fast Freddy; Fast Freddy Contest; Parkland\u27s 1981-82 men\u27s basketball squad; Problems snowball at weekend volleyball tournamenthttps://spark.parkland.edu/prospectus_1981/1003/thumbnail.jp

Markers of Mitochondrial Mitophagy and Fusion - to - Fission Ratio are Greater in Older vs. Young Rats

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Prospectus, March 3, 1982

JOHNSON DISCUSSES REAGAN ECONOMY; News In Brief; College loan cuts hurting middle-income families; Meltdown reveals bonanza of useful items, treasures; What is intellectual freedom?: Your ideas can win; PC happenings…: Program focuses on language, Trouble falling asleep?, Winter playtime scheduled, Cowger discusses Indian lifestyle; Officers elected; Center offers counsel, U of I sponsors Engineering Open House, Apply for achievement award; Interested in singing? Here\u27s chance; Drama department presents; Circle K celebrates week of activities; From official tornado photographer to P.C. instructor: Donna Drysdale leads unusual life; Sugar Babies : tribute to evening of burlesque; Classifieds; U-2 good, not as good as crowd expected; \u27Personal Best\u27: Controversy arouses interest; Fifth-ranked baseball team back to face tough season Cobras Coverage sports insert pages 9-12https://spark.parkland.edu/prospectus_1982/1026/thumbnail.jp

Prospectus, October 28, 1981

SENIORS VISIT PARKLAND; News In Brief; Donate blood--help others: One that was helped; Gazette to go electronic; Get on P.C. blood donor team; Images: students at creative best; Homecoming idea conceived by 2 bored men; Western look phasing out; \u27Antigone\u27 opens Nov. 12; County moves to METCAD; Spend year abroad, see Scandinavia; Be safe on Halloween; Stories welcome; P.C. Happ\u27nin\u27s: Ski club plans finances, Prayers offered, EMT workshop set, Model ships presented, CHI sponsors program, Encouraging parents, Stugo discusses food; Chief Illiniwek -- Part of Illini tradition; Moody Blues: classic; Halloween hits early; Willie Nesbit wins Freddy contest; Sports Notes; Girls open at Sugar Grove; Illini football pleases fan; Fast Freddy Contest; Correction; \u27Gallipoli\u27 deals with war, friendship, death; Classifieds; Duvall stars in \u27Confessions\u27; \u27Marbles\u27: nice surprise; Library plans A-V Week; Laugh at \u27Merlin\u27https://spark.parkland.edu/prospectus_1981/1007/thumbnail.jp

Huntingtin bodies sequester vesicle-associated proteins by a polyproline-dependent interaction

Polyglutamine expansion in the N terminus of huntingtin (htt) causes selective neuronal dysfunction and cell death by unknown mechanisms. Truncated htt expressed in vitro produced htt immunoreactive cytoplasmic bodies (htt bodies). The fibrillar core of the mutant htt body resisted protease treatment and contained cathepsin D, ubiquitin, and heat shock protein (HSP) 40. The shell of the htt body was composed of globules 14-34 nm in diameter and was protease sensitive. HSP70, proteasome, dynamin, and the htt binding partners htt interacting protein 1 (HIP1), SH3-containing Grb2-like protein (SH3GL3), and 14.7K-interacting protein were reduced in their normal location and redistributed to the shell. Removal of a series of prolines adjacent to the polyglutamine region in htt blocked formation of the shell of the htt body and redistribution of dynamin, HIP1, SH3GL3, and proteasome to it. Internalization of transferrin was impaired in cells that formed htt bodies. In cortical neurons of Huntington's disease patients with early stage pathology, dynamin immunoreactivity accumulated in cytoplasmic bodies. Results suggest that accumulation of a nonfibrillar form of mutant htt in the cytoplasm contributes to neuronal dysfunction by sequestering proteins involved in vesicle trafficking