NEEDLELESS INJECTION SYSTEM: AN OVERVIEW

Needle-less injections are designed to solve the problem associated with hypodermic needle injection. Needle-less injection system was first introduced by Marshell Lockhart in1936. Needle-less system is based on the principle of electrophoresis to deliver the medicament through the skin. This devices are easy to use, it does not required any skilled person. This review is inclined on the needle-less injection system which gives detail information about advantages, disadvantages of the system. This review describes needle-free injection technology involving the generation of force by using compressed gas upon actuation in order to deliver a drug at very high speed through a nozzle. This review also gives brief knowledge about the components. This review also gives brief information about injection methods i. e. spring load jet injector, battery powdered jet injector, and gas powdered jet injector

A REVIEW ON FUNCTIONAL COMPARISON OF 5-HT1A AND 5-HT2C RECEPTORS

5-HT neurotransmission system is targeted by drugs useful in behavioural disorders, including anxiety, depression, psychosis and eating disorders. 5-HT1A autoreceptors, located on 5-HT neurones of the midbrain raphe nuclei, are coupled to K channels through a pertusis toxin-sensitive G-protein. 5-HT1A receptor agonists inhibit adenylyl cyclase, while 5-HT2C receptor agonists activate two signal transduction pathways coupled with these receptors. 5-HT1A and 5-HT2C receptors have lots potential in treating the disorders with less or no side effects. Keywords: 5-HT1A, 5-HT2C, Receptor