El impacto de la pandemia de COVID-19 en la salud mental de los trabajadores de la salud en Chile: datos iniciales de The Health Care Workers Study

Background: Healthcare workers’ mental health was affected by SARS-CoV-2 pandemic. Aim: To evaluate healthcare workers’ mental health and its associated factors during the pandemic in Chile. Material and Methods: An online self-reported questionnaire was designed including the Goldberg Health Questionnaire, the Patient Health Questionnaire, (PHQ-9), and the Columbia-Suicide Severity Rating Scale among other questions. It was sent to 28,038 healthcare workers. Results: The questionnaire was answered by 1,934 participants, with a median age of 38 years (74% women). Seventy five percent were professionals, and 48% worked at a hospital. Fifty nine percent of respondents had a risk of having a mental health disorder, and 73% had depressive symptoms. Significant associations were found with sex, workplace, and some of the relevant experiences during the pandemic. Fifty one percent reported the need for mental health support, and 38% of them received it. Conclusions: There is a high percentage of health workers with symptoms of psychological distress, depression, and suicidal ideas. The gender approach is essential to understand the important differences found. Many health workers who required mental health care did not seek or received it

Un periodismo de cine: ver, aprender y debatir sobre las rutinas profesionales a través de películas y series de ficción

Depto. de Periodismo y Comunicación GlobalFac. de Ciencias de la InformaciónFALSEsubmitte

[Impact of COVID-19 pandemic on the mental health of healthcare workers].

BACKGROUND: Healthcare workers' mental health was affected by SARS-CoV-2 pandemic. AIM: To evaluate healthcare workers' mental health and its associated factors during the pandemic in Chile. MATERIAL AND METHODS: An online self-reported questionnaire was designed including the Goldberg Health Questionnaire, the Patient Health Questionnaire, (PHQ-9), and the Columbia-Suicide Severity Rating Scale among other questions. It was sent to 28,038 healthcare workers. RESULTS: The questionnaire was answered by 1,934 participants, with a median age of 38 years (74% women). Seventy five percent were professionals, and 48% worked at a hospital. Fifty nine percent of respondents had a risk of having a mental health disorder, and 73% had depressive symptoms. Significant associations were found with sex, workplace, and some of the relevant experiences during the pandemic. Fifty one percent reported the need for mental health support, and 38% of them received it. CONCLUSIONS: There is a high percentage of health workers with symptoms of psychological distress, depression, and suicidal ideas. The gender approach is essential to understand the important differences found. Many health workers who required mental health care did not seek or received it

Evaluation of the implementation progress through key performance indicators in a new multimorbidity patient-centered care model in Chile

Abstract Background Complex health interventions involve deep organizational, structural, and cultural changes that challenge health teams and decision-makers. The explosion of chronic diseases has made the multimorbidity approach a global priority. The Centro de Innovación en Salud ANCORA UC implemented a Multimorbidity Patient-Centered Care Model in the Chilean public health system. Objective This study aims to evaluate the progress of the implementation of the Multimorbidity Patient-Centered Care Model in seven primary care centers through key performance indicators. Methods a set of indicators was designed to evaluate change management, operations, installation of new roles, and services and activities of the intervention strategy of the model. Key performance indicators were identified to monitor the implementation progress on minimal components for the model’s sustainability. Each item was assigned against an expected minimum score of 67% of progress from the overall score. They were monitored twice in seven primary health centers in 2019 and 2020, which intervened 22,642 patients with the intervention. Results The results showed that six of the seven primary care centers reached the minimum implementation threshold. The main advances were in operational conditions, and those with minor progress in implementation were the clinical services. Population size, organization, coordination of the health care teams, additional training, and decision-makers support were key factors that determined the degree of progress in a complex intervention. Conclusion It was possible to measure the progression of the implementation of a complex intervention through key performance indicators delivering relevant information for decision-makers that pursue a successful and faithful implementation. This study provides a valuable tool for the national scale-up of a similar model started in Chile by the Ministry of Health and other countries

Gene therapy reduces ethanol intake in an animal model of alcohol dependence

Background: Some gene polymorphisms strongly protect against the development of alcoholism. A large proportion of East Asians carry a protective inactivating mutation in aldehyde dehydrogenase (ALDH2*2). These subjects display high levels of blood acetaldehyde when consuming alcohol, a condition that exerts a 66 to 99% protection against alcohol abuse and alcoholism. Present knowledge allows the incorporation of therapeutic genes that can modify the expression of disease predisposing genes, an effect that can last from months to years. In line with the above, we have tested if inhibiting the expression of the aldehyde dehydrogenase gene (ALDH2) by an anti-Aldh2 antisense gene can curtail the drive of alcohol-dependent animals to consume alcohol. Methods: Wistar-derived rats bred as high alcohol drinkers (UChB; Universidad de Chile Bibulous) were rendered alcohol dependent by a 2-month period of voluntary ethanol (10%) intake, subjected to a 3-day withdrawal period and further allowed

Investigaciones de estudiantes

In this last chapter, 5 investigations carried out by students are listed of the Faculty of Architecture of the University of Palermo. These jobs were tutored by teachers and are part of the learning process developed through through research in classrooms and workshops. The authors of the works listed are: Martin Alday, Leandro Palacios, Catriel Trasmonte, Julieta Lema, Candela Belén Robles and Facundo Sacks, Agustina Prieto and Paula SapagEn este último capítulo se listan 5 investigaciones desarrolladas por alumnos de la Facultad de Arquitectura de la Universidad de Palermo. Estos trabajos fueron tutoriados por profesores y forman parte del proceso de aprendizaje desarrollado a través de la investigación en las aulas y talleres. Los autores de los trabajos listados son: Martin Alday, Leandro Palacios, Catriel Trasmonte, Julieta Lema, Candela Belén Robles y Facundo Sacks, Agustina Prieto y Paula SapagNeste último capítulo, são listadas 5 investigações realizadas pelos alunos da Faculdade de Arquitetura da Universidade de Palermo. Essas obras foram supervisionadas pelos professores e fazem parte do processo de aprendizagem desenvolvido de pesquisa em salas de aula e oficinas. Os autores das obras listadas são: Martin Alday, Leandro Palacios, Catriel Trasmonte, Julieta Lema, Candela Belén Robles y Facundo Sacks, Agustina Prieto e Paula Sapag

Mecanismos moleculares en la apoptosis del cardiomiocito y sus proyecciones patológicas y terapéuticas

La apoptosis junto a la paraptosis y la necrosis constituyen las principales formas de muerte celular conocidas hasta la fecha. La apoptosis se caracteriza por una disminución del volumen celular y formación de "cuerpos apoptóticos", manteniendo íntegra la membrana plasmática, evitando así el vaciamiento del contenido intracelular y el desarrollo de un proceso inflamatorio. En el cardiomiocito se han descrito dos vías apoptóticas: la tipo I (extrínseca o mediada a través de receptores de muerte) y la tipo II (intrínseca o mitocondrial). Ambas vías convergen en la caspasa 3, que es la responsable de la ejecución final de la apoptosis. Existe apoptosis en varias enfermedades cardíacas, como por ejemplo en la insuficiencia cardíaca de origen isquémico y no isquémico, en el infarto al miocardio y en las arritmias. Debido a que los cardiomiocitos son incapaces de proliferar, su muerte conduce a la pérdida de masa cardíaca, disminución de la capacidad contráctil del miocardio y remodelamiento. Dado que la apoptosis del cardiomiocito contribuye directamente a un deterioro funcional irreversible del corazón y favorece el desarrollo de diversas cardiopatías, el conocimiento de sus mecanismos y blancos moleculares proporcionará novedosas estrategias terapéuticas para la prevención y tratamiento de las diferentes cardiopatías

Additional file 1 of Associations between the stringency of COVID-19 containment policies and health service disruptions in 10 countries

Additional file 1: Supplemental Table 1. Health services by service type category in 10 countries. Supplemental Table 2. Definition of containment policies and dichotomous recoding. Supplemental Table 3. Results from multi-level linear regression model for the association between the OxCGRT stringency index and relative service volumes (median stringency index). Supplemental Table 4. Results from multi-level linear regression model for the association between the OxCGRT stringency index and relative service volumes (max stringency index)