Aplicación de la tecnología multimedia y Campus Virtual en la enseñanza y el aprendizaje de las Filologías

Memoria final de los proyectos de innovación y mejora de la calidad docente (PIMCD) concedido a la Facultad de Filología en el año 2008 por el Vicerrectorado de Desarrollo y Calidad de la Docencia. Presenta la metodología, recursos empleados y resultados obtenidos respecto de tres objetivos: 1) Formación y apoyo a los profesores en el uso del CV y herramientas específicas para las filologías; 2) Formación y apoyo a los profesores para el uso de la Tecnología Multimedia del nuevo Laboratorio de enseñanza de las lenguas y sus literaturas; y 3) Difusión del uso docente e investigador de la informática y las TIC en la Facultad de Filología

Una prospectiva sobre el uso de la Informática en Filología para la docencia e investigación. Informe de la Jornada Científica del 5 de noviembre de 2008. Facultad de Filología, UCM

Este documento recoge una síntesis de las experiencias de algunos grupos de investigación y profesores de Filología, presentadas en la Jornada Científica del 5 de noviembre de 2008, sobre el impacto que están teniendo las herramientas informáticas en los métodos de enseñanza, aprendizaje e investigación filológicos, así como los beneficios y perjuicios de su utilización en la docencia y la investigación

MXRA5 is a TGF-β1-regulated human protein with anti-inflammatory and anti-fibrotic properties

Current therapy for chronic kidney disease (CKD) is unsatisfactory because of an insufficient understanding of its pathogenesis. Matrix remodelling-associated protein 5 (MXRA5, adlican) is a human protein of unknown function with high kidney tissue expression, not present in rodents. Given the increased expression of MXRA5 in injured tissues, including the kidneys, we have suggested that MXRA5 may modulate kidney injury. MXRA5 immunoreactivity was observed in tubular cells in human renal biopsies and in urine from CKD patients. We then explored factors regulating MXRA5 expression and MXRA5 function in cultured human proximal tubular epithelial cells and explored MXRA5 expression in kidney cancer cells and kidney tissue. The fibrogenic cytokine transforming growth factor-β1 (TGFβ1) up-regulated MXRA5 mRNA and protein expression. TGFβ1-induced MXRA5 up-regulation was prevented by either interference with TGFβ1 activation of the TGFβ receptor 1 (TGFBR1, ALK5) or by the vitamin D receptor agonist paricalcitol. By contrast, the pro-inflammatory cytokine TWEAK did not modulate MXRA5 expression. MXRA5 siRNA-induced down-regulation of constitutive MXRA5 expression resulted in higher TWEAK-induced expression of chemokines. In addition, MXRA5 down-regulation resulted in a magnified expression of genes encoding extracellular matrix proteins in response to TGFβ1. Furthermore, in clear cell renal cancer, von Hippel–Lindau (VHL) regulated MXRA5 expression. In conclusion, MXRA5 is a TGFβ1- and VHL-regulated protein and, for the first time, we identify MXRA5 functions as an anti-inflammatory and anti-fibrotic molecule. This information may yield clues to design novel therapeutic strategies in diseases characterized by inflammation and fibrosis.This work was supported by grants from the Instituto de Salud Carlos III (FEDER funds ISCIII RETIC REDINREN RD12/0021, PI13/00047, PI15/00298, PIE13/00051, Comunidad de Madrid (CIFRA S2010/BMD-2378), Sociedad Española de Nefrología. Programa Intensificación Actividad Investigadora (ISCIII/Agencia Laín-Entralgo/CM) to AO, ISCIII Joan Rodes JR14/00028 to BFF and Miguel Servet MS12/03262, MS14/00133, MECD to JP, and Biobanco IIS-FJD PT13/0010/001

Analysis of Mobile Commerce in the SMEs of the European Union

This paper examines the situation of e-commerce and m-commerce in SMEs in the European Union and analyses if their behaviour in this field is determined by a series of factors, such as the size of the company, the type of business, turnover, etc. which may also influence their needs of specific training for their employees. This study is based on an online survey responded by 674 SMEs from eight different countries in Europe, aimed at providing training assistance to SMEs to support their efforts towards m-commerce. The objective is the analysis of the skills and knowledge to be recommended to employees of SMEs for a better preparation to implement the companies\u27 strategy of m-commerce. Although analysis of results from survey has supported the initial goal of developing training courses for m-commerce which include different economic, legal and technical topics, it has mainly provided very relevant conclusions on the factors which impact the adoption of e-commerce and m-commerce by SMEs

Big Data and Skills Frameworks to Determine Recommended Profiled of Soft Skills for IS Development

Information systems development (ISD) is a social activity where non-cognitive skills (NCS), frequently known as soft skills, are a key factor. Previous efforts to determine the recommended NCS for the ISD professional roles got limited results due to the use of manual procedures, absence of reference frameworks and small size of samples. This work presents a new approach which exploits existing reference models like ESCO, e-CF and NCSF (NCS Framework) as basis to analyse big datasets offered by tools like the ESCO database with thousands of relations between occupations and skills and the Ovate tool with millions of online vacancies. The combination of information from job market with the opinion of experts from ESCO provides a stronger basis for recommended NCS profiles for ISD professional roles, a promising option for an aspect not extensively explored

Clinical proteomics in kidney disease as an exponential technology: Heading towards the disruptive phase

Exponential technologies double in power or processing speed every year, whereas their cost halves. Deception and disruption are two key stages in the development of exponential technologies. Deception occurs when, after initial introduction, technologies are dismissed as irrelevant, while they continue to progress, perhaps not as fast or with so many immediate practical applications as initially thought. Twenty years after the first publications, clinical proteomics is still not available in most hospitals and some clinicians have felt deception at unfulfilled promises. However, there are indications that clinical proteomics may be entering the disruptive phase, where, once refined, technologies disrupt established industries or procedures. In this regard, recent manuscripts in CKJ illustrate how proteomics is entering the clinical realm, with applications ranging from the identification of amyloid proteins in the pathology lab, to a new generation of urinary biomarkers for chronic kidney disease (CKD) assessment and outcome prediction. Indeed, one such panel of urinary peptidomics biomarkers, CKD273, recently received a Food and Drug Administration letter of support, the first ever in the CKD field. In addition, a must-read resource providing information on kidney disease-related proteomics and systems biology databases and how to access and use them in clinical decision-making was also recently published in CKJ.Grant support was received from: ISCIII and FEDER funds PI13/00047; EUTOX, CP12/03262, CP14/00133, PI15/00298, PI14/00386, PI15/01460, PI16/01900, PI16/02057; Diabetes Cancer Connect PIE13/00051; Sociedad Española de Nefrologia; FRIAT; and ISCIII-RETIC REDinREN RD016/009. Salary support was received from: ISCIII Miguel Servet to A.B.S., A.M.R. and M.D.S.-N.; Joan Rodes to B.F.-F; and Programa Intensificación Actividad Investigadora (ISCIII/Agencia Laín-Entralgo/CM) to A.O

Ten Things Every Psychologist Should Know About Treating Psychological Disorders in Victims of Terrorism

Terrorism remains one of the most serious global problems, affecting a very large number of people, a signifi cant percentage of whom can suffer psychological disorders arising from a terrorist attack. The purpose of this article is to describe the current state of scientifi knowledge about these psychological disorders and their treatment. Method: Systematic narrative or meta-analytical reviews of the scientifi literature on the subject published between 2010 and 2020 were searched for in PsycINFO, MEDLINE, and PTSDpubs. Results: The search located 16 systematic reviews whose findings were analyzed, leading to ten conclusions about the most common psychological disorders and their progression, the type and percentage of victims who will be most affected by them, and the most effective and useful treatments for those disorders during the various phases following an attack. Conclusions: After a terrorist attack, both direct and indirect victims will need shortand mid-term psychological care and follow up. Direct victims, the direct relatives of any deceased, and other victims signifi cantly exposed to the attack or its consequences, will also need long- and very long-term care and follow up. Currently, trauma-focused cognitive-behavioral therapies are the treatment of choice for victims in the rescue, recovery, and returnto-life phases