Comparative Performance Of A Charcoal Dual Media Filter And A Conventional Rapid Sand Filter

Filtration tests were conducted to assess the performance of a dual media filter (DMF) using charcoal in comparison to a conventional rapid sand filter (RSF) for the same kaolin solution in influent water. Assessment of media characteristics was based on appearance, size, relative density, acid solubility and physical stability. The dual media filter exhibited a turbidity removal capacity of 1.4 times that of the conventional rapid sand filter. Gradients obtained from plots of headloss against time for the RSF and DMF were 0.2 and 0.5 respectively indicating a higher rate of head loss development in the RSF than the DMF. About 86% of the accumulated material in both RSF and DMF was washed away during the first four minutes of backwashing with combined air and water scour. The DMF had a higher bed expansion rate of 40% more than the RSF. This could be attributed to the lower density of charcoal compared with sand.    &nbsp

An Evaluation of the Effects of Lead on the Biodegradation of Organic Wastes

This study constitutes an additional step in limiting the concentration of lead in wastewater effluent from waste stabilization ponds. The effects of lead on the biodegradation rate of organic wastes were investigated at lead concentrations of 0, 5, 10, 20, 30, 40, 50, 75, 100, 125, 150, 200mg/l in batch cultures. Several runs were in order to determine temperature effects. A model was proposed to predict deoxygenation rate for different concentrations of lead at various temperatures. The model parameters  namely the ultimate BOD, reaction rate constant and lag time were optimized by ordinary least squares (OLS) using the modified Gompertz model. The ultimate BOD and lag time increased as lead concentration was increased. However the deoxygenation rate decreased as lead concentration increased. The deoxygenation rate and ultimate BOD had maximum values at optimum temperature range of 30.15-33.50 oC. &nbsp

Nigerian water resources management – an overview

Effective management of a country’s water resources contributes toward its sustainable development. The aim of this paper is to give an overview of Nigeria’s surface and underground water sources alongside agencies charged with functions covering all facets in water resources development and management. Nigeria consists of three broad agro-ecological zones; the northern Sudan Savannah, the Guinea Savannah and the southern rainforest spread across eight hydrological areas for the purpose of water resources management. The Federal Ministry of Water Resources is responsible for large water resources development projects and water allocation between states; comprising of sixteen (16) parastatals and agencies made up of twelve (12) River Basin Development Authorities (RBDAs), Nigeria Hydrological Services Agency (NIHSA), Nigeria Integrated Water Resources Management Commission (NIWRMC), Gurara Water Management Authority (GWMA), and the National Water Resources Institute (NWRI). The country has four river drainage systems and 264 dams. Recent studies of Nigerian water reserves (surface and groundwater sources) indicated that there are large supplies, and the country has surface and groundwater resources potentials of 267.3BCM and 51.9BCM respectively

Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2)

\ua9 2023, Springer Nature Limited. The Global Parkinson’s Genetics Program (GP2) will genotype over 150,000 participants from around the world, and integrate genetic and clinical data for use in large-scale analyses to dramatically expand our understanding of the genetic architecture of PD. This report details the workflow for cohort integration into the complex arm of GP2, and together with our outline of the monogenic hub in a companion paper, provides a generalizable blueprint for establishing large scale collaborative research consortia

Multi-ancestry genome-wide association meta-analysis of Parkinson’s disease

\ua9 2023, This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply. Although over 90 independent risk variants have been identified for Parkinson’s disease using genome-wide association studies, most studies have been performed in just one population at a time. Here we performed a large-scale multi-ancestry meta-analysis of Parkinson’s disease with 49,049 cases, 18,785 proxy cases and 2,458,063 controls including individuals of European, East Asian, Latin American and African ancestry. In a meta-analysis, we identified 78 independent genome-wide significant loci, including 12 potentially novel loci (MTF2, PIK3CA, ADD1, SYBU, IRS2, USP8, PIGL, FASN, MYLK2, USP25, EP300 and PPP6R2) and fine-mapped 6 putative causal variants at 6 known PD loci. By combining our results with publicly available eQTL data, we identified 25 putative risk genes in these novel loci whose expression is associated with PD risk. This work lays the groundwork for future efforts aimed at identifying PD loci in non-European populations

Author Correction: Elucidating causative gene variants in hereditary Parkinson’s disease in the Global Parkinson’s Genetics Program (GP2)

Correction to: s41531-023-00526-9 npj Parkinson’s Disease, published online 27 June 2023 In this article the Global Parkinson’s Genetics Program (GP2) members names and affiliations were missing in the main author list of the Original article which are listed in the below

Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2)

The Global Parkinson’s Genetics Program (GP2) will genotype over 150,000 participants from around the world, and integrate genetic and clinical data for use in large-scale analyses to dramatically expand our understanding of the genetic architecture of PD. This report details the workflow for cohort integration into the complex arm of GP2, and together with our outline of the monogenic hub in a companion paper, provides a generalizable blueprint for establishing large scale collaborative research consortia

Defining the causes of sporadic Parkinson's disease in the global Parkinson's genetics program (GP2)

The Global Parkinson’s Genetics Program (GP2) will genotype over 150,000 participants from around the world, and integrate genetic and clinical data for use in large-scale analyses to dramatically expand our understanding of the genetic architecture of PD. This report details the workflow for cohort integration into the complex arm of GP2, and together with our outline of the monogenic hub in a companion paper, provides a generalizable blueprint for establishing large scale collaborative research consortia

Multi-ancestry genome-wide association meta-analysis of Parkinson?s disease

Although over 90 independent risk variants have been identified for Parkinson’s disease using genome-wide association studies, most studies have been performed in just one population at a time. Here we performed a large-scale multi-ancestry meta-analysis of Parkinson’s disease with 49,049 cases, 18,785 proxy cases and 2,458,063 controls including individuals of European, East Asian, Latin American and African ancestry. In a meta-analysis, we identified 78 independent genome-wide significant loci, including 12 potentially novel loci (MTF2, PIK3CA, ADD1, SYBU, IRS2, USP8, PIGL, FASN, MYLK2, USP25, EP300 and PPP6R2) and fine-mapped 6 putative causal variants at 6 known PD loci. By combining our results with publicly available eQTL data, we identified 25 putative risk genes in these novel loci whose expression is associated with PD risk. This work lays the groundwork for future efforts aimed at identifying PD loci in non-European populations

The effect of varied mix proportion and water-cement ratio on the compressive strength of medium grade concretepoduced from Bama gravel

Concrete cubes produced from Bama gravel (Category B) using varied mix proportions and water-cement ratios were subjected to compressive strength and density tests at the curing ages 7, 14 and 28 days. The results indicated that the strength of 28.00Nmm-2 was recorded from the mix proportion of 1:1/2:4 and water-cement ratio of 0.55, which corresponds to a density of 2495 kgm-3. A careful inspection of the results obtained generally shows that the strenfths are inversely proportional to the fine aggregate content and water-cement ratios. It is recommended that great care should be taken while mixing the aggregate proportions of the Bama gravel in order to obtain high quality medium grade concrete for construction purposes