A randomized clinical study to evaluate the effect of denture adhesive application technique on food particle accumulation under dentures

ACKNOWLEDGEMENTS Editorial assistance was provided by Julie Adkins of Anthemis Consulting Ltd and Eleanor Roberts of Beeline Science Communications Ltd, both funded by GSK Consumer Healthcare, Weybridge, UK, in accordance with Good Publication Practice (GPP3) guidelines.Peer reviewedPublisher PD

A study of photoionized gas in two HII regions of the N44 complex in the LMC using MUSE observations

We use the optical integral field observations with Multi-Unit Spectroscopic Explorer (MUSE) on the Very Large Telescope, together with CLOUDY photoionization models to study ionization structure and physical conditions of two luminous HII regions in N44 star-forming complex of the Large Magellanic Cloud. The spectral maps of various emission lines reveal a stratified ionization geometry in N44 D1. The spatial distribution of [O I] 6300A emission in N44 D1 indicates a partially covered ionization front at the outer boundary of the H II region. These observations reveal that N44 D1 is a Blister HII region. The [O I] 6300A emission in N44 C does not provide a well-defined ionization front at the boundary, while patches of [S II] 6717 A and [O I] 6300A emission bars are found in the interior. The results of spatially resolved MUSE spectra are tested with the photoionization models for the first time in these HII regions. A spherically symmetric ionization-bounded model with a partial covering factor, which is appropriate for a Blister HII region can well reproduce the observed geometry and most of the diagnostic line ratios in N44 D1. Similarly, in N44 C we apply a low density and optically thin model based on the observational signatures. Our modeling results show that the ionization structure and physical conditions of N44 D1 are mainly determined by the radiation from an O5 V star. However, local X-rays, possibly from supernovae or stellar wind, play a key role. In N44 C, the main contribution is from three ionizing stars.Comment: Accepted for publication in Ap

Effects of a sodium fluoride- and phytate-containing dentifrice on remineralisation of enamel erosive lesions—an in situ randomised clinical study

ObjectiveThe objective of this work was to evaluate effects of a dentifrice containing sodium fluoride (1150 ppm F) and the organic polyphosphate phytate (0.85% w/w of the hexa-sodium salt) on in situ remineralisation of early enamel erosive lesions and resistance to subsequent demineralisation.Materials and methodsSubjects (n = 62) wore palatal appliances holding eight bovine enamel specimens with pre-formed erosive lesions. They brushed their natural teeth with the phytate test dentifrice (TD); a positive control dentifrice (PC, 1150 ppm fluoride as NaF); a reference dentifrice (RD, disodium pyrophosphate + 1100 ppm fluoride as NaF) or a negative control dentifrice (NC, fluoride-free) in a randomised, double-blind, crossover design. Specimens were removed at 2, 4 and 8 h post-brushing and exposed to an ex vivo acid challenge. Surface microhardness (Knoop) was measured at each stage. The primary efficacy variable was relative erosion resistance (RER); other variables included the surface microhardness recovery (SMHR), acid resistance ratio (ARR) and enamel fluoride uptake (EFU).ResultsAfter 4 h, the results for RER, ARR and EFU were in the order PC > TD = RD > NC with PC > TD = RD = NC for SMHR. Results at 2 and 8 h were generally consistent with the 4 h data. Mineralisation progressed over time. Dentifrices were generally well-tolerated.ConclusionsIn this in situ model, addition of phytate or pyrophosphate to a fluoride dentifrice inhibited the remineralising effect of fluoride. Both formulations still delivered fluoride to the enamel and inhibited demineralisation, albeit to a lesser extent than a polyphosphate-free dentifrice.Clinical relevanceAddition of phytate or pyrophosphate to a fluoride dentifrice may reduce its net anti-erosive properties

Impact of frequency of denture cleaning on microbial and clinical parameters - a bench to chairside approach

Objective: Robust scientific and clinical evidence of how to appropriately manage denture plaque is lacking. This two-part study (i) developed an in vitro model of denture plaque removal, and (ii) assessed effectiveness of these approaches in a randomised clinical trial. Method: (i) a complex denture plaque model was developed using the dominant microbial genera from a recent microbiome analyses. Biofilms formed on polymethylmethacrylate were brushed daily with a wet toothbrush, then either treated daily for 5 days or only on Days 1 and 5 with Polident® denture cleanser tablets (3 min soaking). Quantitative and qualitative microbiological assessments were performed. (ii), an examiner-blind, randomised, crossover study of complete maxillary denture wearers was performed (n = 19). Either once-daily for 7 days or on Day 7 only, participants soaked dentures for 15 min using Corega® denture cleansing tables, then brushed. Denture plaque microbiological assessment used sterilized filter paper discs. Results: The in vitro model showed daily cleaning with denture cleanser plus brushing significantly reduced microbial numbers compared to intermittent denture cleaning with daily brushing (p < 0.001). The clinical component of the study showed a statistically significant reduction in denture plaque microbial numbers in favour of daily versus weekly treatment (aerobic bacteria p = 0.0144). Both in vitro and in vivo studies showed that denture plaque biofilm composition were affected by different treatment arms. Conclusions: This study demonstrated that daily denture cleansing regimens are superior to intermittent denture cleansing, and that cleansing regimens can induce denture plaque compositional changes. Clinicaltrials.gov registration: NCT02780661

A Reconfigurable Coprocessor for Redundant Radix-4 Arithmetic Abstract

We present the implementation of a reconfigurable arithmetic coprocessor based on a fast parallel multiplication scheme proposed in [1]. In this coprocessor, we have implemented four basic arithmetic operations (viz. addition, subtraction, multiplication and complementation) and four primary logic operations (viz. AND, OR, EX-OR and NOT). The coprocessor can be directly accessed from the PC by an interfacing software implemented in [19]. In this project, we have developed a complete set of VHDL modules, which through different stages of Xilinx Foundation Express 3.1i, finally give rise to the bitstream file which is downloaded from the PC to the FPGA board to configure the FPGA chip (target architecture: XC4010E TM) as the desired arithmetic coprocessor. Acknowledgement In the beginning, we would like to pay our sincerest thanks and gratitude to Prof. Bhabani P. Sinha for allowing us to use his paper on “Fast Parallel multiplication using redundant quarternary number system ” [1] for FPGA implementation. We would also like to acknowledge here the thesis work by Koushik Sinha [20] as the first step towards FPG