2 research outputs found
Solid-Phase Synthesis of Pyrrole Derivatives through a Multicomponent Reaction Involving Lys-Containing Peptides
The synthesis of pyrroles has received
considerable attention because
of their biological and pharmaceutical activities. Herein we describe
a solid-phase multicomponent reaction that utilizes Lys as a N donor,
β-nitrostyrenes, 1,3-dicarbonyl compounds, and FeCl<sub>3</sub> as an easily accessible catalyst under microwave irradiation to
afford the subsequent pyrrole derivatives in high conversions. The
strategy combines three of the most powerful tools in modern synthetic
chemistry: the solid-phase mode, microwave activation, and a multicomponent
reaction. The excellent results in terms of rapidity, versatility,
and purity obtained herein support once again that this combined strategy
is efficient for gaining chemical diversity