Processos de transporte em misturas gasosas: formas explícitas dos coeficientes de difusão ordinária e viscosidade

Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-graduação em Engenharia Mecânica

Evaluación del desempeño por competencia en una institución hospitalaria : experiencia de las enfermeras

Objetivo: Conhecer a experiência de enfermeiros na implantação do sistema de avaliação de desempenho por competências em uma instituição hospitalar. Método: Estudo descritivo, qualitativo, desenvolvido com 20 enfermeiros de uma instituição hospitalar. Os dados, coletados entre novembro e dezembro de 2018, por meio de entrevistas semiestruturadas, foram submetidos à análise de conteúdo temática. Resultados: Emergiram três categorias: gestão por competências, considerações acerca da implantação na instituição; o processo avaliativo sob a óptica dos enfermeiros, compreensões inerentes; e, avaliação de desempenho por competências, impactos percebidos pelos enfermeiros nos técnicos de enfermagem. Conclusão: A avaliação de desempenho por competências aplicada no contexto do serviço de enfermagem, em uma instituição hospitalar, favorece o desenvolvimento dos enfermeiros enquanto gestores de equipes e contribui no planejamento e proposição de planos para o desenvolvimento de competências nos técnicos de enfermagem, refletindo na qualidade e segurança dos cuidados dispensados aos pacientes.Objective: to know the nurses’ experience in the implementation of the competence-based performance evaluation system in a hospital institution. Method: descriptive, qualitative study, developed with 20 nurses from a hospital. The data was collected between November and December 2018, through semi-structured interviews, and were subjected to thematic content analysis. Results: Three categories emerged: management by competencies, considerations about implantation in the institution; the evaluation process from the perspective of nurses, inherent understandings; and, competency-based performance evaluation, impacts perceived by nurses on nursing technicians. Conclusion: Competencybased performance evaluation applied in the context of the nursing service in a hospital, favors the development of nurses as team managers and contributes to the planning and proposition of plans for the development of skills in nursing technicians, reflecting on quality and safety of patient care.Objetivo: Conocer la experiencia de las enfermeras en la implementación del sistema de evaluación del desempeño por competencias en un hospital. Método: Estudio descriptivo, cualitativo, desarrollado con 20 enfermeras de un hospital. Los datos, recopilados entre noviembre y diciembre de 2018, a través de entrevistas semiestructuradas, fueron sometidos a análisis de contenido temático. Resultados: surgieron tres categorías: gestión por competencias, consideraciones sobre la implantación en la institución; el proceso de evaluación desde la perspectiva de las enfermeras, entendimientos inherentes; y evaluación del desempeño por habilidades, impactos percibidos por las enfermeras en los técnicos de enfermería. Conclusión: La evaluación del desempeño por competencias aplicadas en el contexto del servicio de enfermería, en una institución hospitalaria, favorece el desarrollo de las enfermeras como jefes de equipo y contribuye a la planificación y propuesta de planes para el desarrollo de competencias en técnicos de enfermería, reflejándose en el calidad y seguridad de la atención al paciente

The repositioned drugs disulfiram/diethyldithiocarbamate combined to benznidazole: Searching for Chagas disease selective therapy, preventing toxicity and drug resistance

Chagas disease (CD) affects at least 6 million people in 21 South American countries besides several thousand in other nations all over the world. It is estimated that at least 14,000 people die every year of CD. Since vaccines are not available, chemotherapy remains of pivotal relevance. About 30% of the treated patients cannot complete the therapy because of severe adverse reactions. Thus, the search for novel drugs is required. Here we tested the benznidazole (BZ) combination with the repositioned drug disulfiram (DSF) and its derivative diethyldithiocarbamate (DETC) upon Trypanosoma cruzi in vitro and in vivo. DETC-BZ combination was synergistic diminishing epimastigote proliferation and enhancing selective indexes up to over 10-fold. DETC was effective upon amastigotes of the BZ- partially resistant Y and the BZ-resistant Colombiana strains. The combination reduced proliferation even using low concentrations (e.g., 2.5 µM). Scanning electron microscopy revealed membrane discontinuities and cell body volume reduction. Transmission electron microscopy revealed remarkable enlargement of endoplasmic reticulum cisternae besides, dilated mitochondria with decreased electron density and disorganized kinetoplast DNA. At advanced stages, the cytoplasm vacuolation apparently impaired compartmentation. The fluorescent probe H2-DCFDA indicates the increased production of reactive oxygen species associated with enhanced lipid peroxidation in parasites incubated with DETC. The biochemical measurement indicates the downmodulation of thiol expression. DETC inhibited superoxide dismutase activity on parasites was more pronounced than in infected mice. In order to approach the DETC effects on intracellular infection, peritoneal macrophages were infected with Colombiana trypomastigotes. DETC addition diminished parasite numbers and the DETC-BZ combination was effective, despite the low concentrations used. In the murine infection, the combination significantly enhanced animal survival, decreasing parasitemia over BZ. Histopathology revealed that low doses of BZ-treated animals presented myocardial amastigote, not observed in combination-treated animals. The picrosirius collagen staining showed reduced myocardial fibrosis. Aminotransferase de aspartate, Aminotransferase de alanine, Creatine kinase, and urea plasma levels demonstrated that the combination was non-toxic. As DSF and DETC can reduce the toxicity of other drugs and resistance phenotypes, such a combination may be safe and effective

Aerodynamical and mechanical design of turbine blade

The present work presents a study concerned with the project of a wind turbine. This task is basically shared in two steps. The first one is the blades aerodynamic project, with the purpose of taking more advantage of the wind kinetic energy and the second one is concerned with the mechanical project of the blades, in order to support the loads over the blades during the operation period. The graphical modeling and the mechanical project of the blades are performed with the computational softwares AutoCad® and Excel. The commercial code Ansys® is employed to analyze the mechanical resistance and the reliability of the blade. To perform the prediction of the wind action efforts over the blade is used the aerodynamic analysis including forces, such as: axial, tangential, weight and centrifugal ones, and aerodynamic momentum. The blades are composed of fiberglass shell reinforced with plastic material. Vertical and horizontal reinforcements of wood and carbon fiber, respectively, are also employed

Evaluación del desempeño por competencia en una institución hospitalaria : experiencia de las enfermeras

Objetivo: Conhecer a experiência de enfermeiros na implantação do sistema de avaliação de desempenho por competências em uma instituição hospitalar. Método: Estudo descritivo, qualitativo, desenvolvido com 20 enfermeiros de uma instituição hospitalar. Os dados, coletados entre novembro e dezembro de 2018, por meio de entrevistas semiestruturadas, foram submetidos à análise de conteúdo temática. Resultados: Emergiram três categorias: gestão por competências, considerações acerca da implantação na instituição; o processo avaliativo sob a óptica dos enfermeiros, compreensões inerentes; e, avaliação de desempenho por competências, impactos percebidos pelos enfermeiros nos técnicos de enfermagem. Conclusão: A avaliação de desempenho por competências aplicada no contexto do serviço de enfermagem, em uma instituição hospitalar, favorece o desenvolvimento dos enfermeiros enquanto gestores de equipes e contribui no planejamento e proposição de planos para o desenvolvimento de competências nos técnicos de enfermagem, refletindo na qualidade e segurança dos cuidados dispensados aos pacientes.Objective: to know the nurses’ experience in the implementation of the competence-based performance evaluation system in a hospital institution. Method: descriptive, qualitative study, developed with 20 nurses from a hospital. The data was collected between November and December 2018, through semi-structured interviews, and were subjected to thematic content analysis. Results: Three categories emerged: management by competencies, considerations about implantation in the institution; the evaluation process from the perspective of nurses, inherent understandings; and, competency-based performance evaluation, impacts perceived by nurses on nursing technicians. Conclusion: Competencybased performance evaluation applied in the context of the nursing service in a hospital, favors the development of nurses as team managers and contributes to the planning and proposition of plans for the development of skills in nursing technicians, reflecting on quality and safety of patient care.Objetivo: Conocer la experiencia de las enfermeras en la implementación del sistema de evaluación del desempeño por competencias en un hospital. Método: Estudio descriptivo, cualitativo, desarrollado con 20 enfermeras de un hospital. Los datos, recopilados entre noviembre y diciembre de 2018, a través de entrevistas semiestructuradas, fueron sometidos a análisis de contenido temático. Resultados: surgieron tres categorías: gestión por competencias, consideraciones sobre la implantación en la institución; el proceso de evaluación desde la perspectiva de las enfermeras, entendimientos inherentes; y evaluación del desempeño por habilidades, impactos percibidos por las enfermeras en los técnicos de enfermería. Conclusión: La evaluación del desempeño por competencias aplicadas en el contexto del servicio de enfermería, en una institución hospitalaria, favorece el desarrollo de las enfermeras como jefes de equipo y contribuye a la planificación y propuesta de planes para el desarrollo de competencias en técnicos de enfermería, reflejándose en el calidad y seguridad de la atención al paciente