697 research outputs found
Role of business leaders in the integrality of the working indivual
In a world where the benefit to the common good has been overshadowed by the need to spur demand to increase profitability, one begins to wonder if business has turned a blind eye and if the workforce has grown so detached that who they are at work is different from who they are outside the workplace. Fragmentation (Alford and Naughton 2001) and compartmentalization (McIntyre as cited in Martin 2011, Rozuel 2011) at varying degrees and across different arenas have become possible traps for every worker
The Effective Lagrangian for Bulk Fermions in Models with Extra Dimensions
We compute the dimension 6 effective Lagrangian arising from the tree level
integration of an arbitrary number of bulk fermions in models with warped extra
dimensions. The coefficients of the effective operators are written in terms of
simple integrals of the metric and are valid for arbitrary warp factors, with
or without an infrared brane, and for a general Higgs profile. All relevant
tree level fermion effects in electroweak and flavor observables can be
computed using this effective Lagrangian.Comment: 22 pages. V2: typos corrected, matches published versio
A protective role for the Lectin CD169/Siglec-1 against a pathogenic murine retrovirus
Lymph- and blood-borne retroviruses exploit CD169/Siglec-1-mediated capture by subcapsular sinus and marginal zone metallophilic macrophages for trans-infection of permissive lymphocytes. However, the impact of CD169-mediated virus capture on retrovirus dissemination and pathogenesis in vivo is unknown. In a murine model of the splenomegaly-inducing retrovirus Friend virus complex (FVC) infection, we find that while CD169 promoted draining lymph node infection, it limited systemic spread to the spleen. At the spleen, CD169-expressing macrophages captured incoming blood-borne retroviruses and limited their spread to the erythroblasts in the red pulp where FVC manifests its pathogenesis. CD169-mediated retroviral capture activated conventional dendritic cells 1 (cDC1s) and promoted cytotoxic CD8+ T cell responses, resulting in efficient clearing of FVC-infected cells. Accordingly, CD169 blockade led to higher viral loads and accelerated death in susceptible mouse strains. Thus, CD169 plays a protective role during FVC pathogenesis by reducing viral dissemination to erythroblasts and eliciting an effective cytotoxic T lymphocyte response via cDC1s
Flavor Phenomenology in General 5D Warped Spaces
We have considered a general 5D warped model with SM fields propagating in
the bulk and computed explicit expressions for oblique and non-oblique
electroweak observables as well as for flavor and CP violating effective
four-fermion operators. We have compared the resulting lower bounds on the
Kaluza-Klein (KK) scale in the RS model and a recently proposed model with a
metric modified towards the IR brane, which is consistent with oblique
parameters without the need for a custodial symmetry. We have randomly
generated 40,000 sets of O(1) 5D Yukawa couplings and made a fit of the quark
masses and CKM matrix elements in both models. This method allows to identify
the percentage of points consistent with a given KK mass, which in turn
provides us with a measure for the required fine-tuning. Comparison with
current experimental data on Rb, FCNC and CP violating operators exhibits an
improved behavior of our model with respect to the RS model. In particular,
allowing 10% fine-tuning the combined results point towards upper bounds on the
KK gauge boson masses around 3.3 TeV in our model as compared with 13 TeV in
the RS model. One reason for this improvement is that fermions in our model are
shifted, with respect to fermions in the RS model, towards the UV brane thus
decreasing the strength of the modifications of electroweak observables.Comment: 28 pages, 7 figures, 4 table
An A4 flavor model for quarks and leptons in warped geometry
We propose a spontaneous A4 flavor symmetry breaking scheme implemented in a
warped extra dimensional setup to explain the observed pattern of quark and
lepton masses and mixings. The main advantages of this choice are the
explanation of fermion mass hierarchies by wave function overlaps, the
emergence of tribimaximal neutrino mixing and zero quark mixing at the leading
order and the absence of tree-level gauge mediated flavor violations. Quark
mixing is induced by the presence of bulk flavons, which allow for cross-brane
interactions and a cross-talk between the quark and neutrino sectors, realizing
the spontaneous symmetry breaking pattern A4 --> nothing first proposed in
[X.G.\,He, Y.Y.\,Keum, R.R.\,Volkas, JHEP{0604}, 039 (2006)]. We show that the
observed quark mixing pattern can be explained in a rather economical way,
including the CP violating phase, with leading order cross-interactions, while
the observed difference between the smallest CKM entries V_{ub} and V_{td} must
arise from higher order corrections. We briefly discuss bounds on the
Kaluza-Klein scale implied by flavor changing neutral current processes in our
model and show that the residual little CP problem is milder than in flavor
anarchic models.Comment: 34 pages, 2 figures; version published in JHE
Low-scale warped extra dimension and its predilection for multiple top quarks
Within warped extra dimension models that explain flavor through geometry,
flavor changing neutral current constraints generally force the Kaluza-Klein
scale to be above many TeV. This creates tension with a natural electroweak
scale. On the other hand, a much lower scale compatible with precision
electroweak and flavor changing neutral current constraints is allowed if we
decouple the Kaluza-Klein states of Standard Model gauge bosons from light
fermions bulk mass parameters). The main
signature for this approach is four top quark production via the Kaluza-Klein
excitations' strong coupling to top quarks. We study single lepton, like-sign
dilepton, and trilepton observables of four-top events at the Large Hadron
Collider. The like-sign dilepton signature typically has the largest discovery
potential for a strongly coupled right-handed top case (M_{KK} \sim 2-2.5
\TeV), while single lepton is the better when the left-handed top couples most
strongly (M_{KK} \sim 2 \TeV). We also describe challenging lepton-jet
collimation issues in the like-sign dilepton and trilepton channels. An
alternative single lepton observable is considered which takes advantage of the
many bottom quarks in the final state. Although searches of other particles may
compete, we find that four top production via Kaluza-Klein gluons is most
promising in a large region of this parameter space.Comment: 35 pages, 8 figures. discussions improved, references adde
Model-Independent Searches for New Quarks at the LHC
New vector-like quarks can have sizable couplings to first generation quarks
without conflicting with current experimental constraints. The coupling with
valence quarks and unique kinematics make single production the optimal
discovery process. We perform a model-independent analysis of the discovery
reach at the Large Hadron Collider for new vector-like quarks considering
single production and subsequent decays via electroweak interactions. An early
LHC run with 7 TeV center of mass energy and 1 fb-1 of integrated luminosity
can probe heavy quark masses up to 1 TeV and can be competitive with the
Tevatron reach of 10 fb-1. The LHC with 14 TeV center of mass energy and 100
fb-1 of integrated luminosity can probe heavy quark masses up to 3.7 TeV for
order one couplings.Comment: 37 pages, 11 figures, 7 table
Heavy-light decay topologies as a new strategy to discover a heavy gluon
We study the collider phenomenology of the lightest Kaluza-Klein excitation
of the gluon, G*, in theories with a warped extra dimension. We do so by means
of a two-site effective lagrangian which includes only the lowest-lying spin-1
and spin-1/2 resonances. We point out the importance of the decays of G* to one
SM plus one heavy fermion, that were overlooked in the previous literature. It
turns out that, when kinematically allowed, such heavy-light decays are
powerful channels for discovering the G*. In particular, we present a
parton-level Montecarlo analysis of the final state Wtb that follows from the
decay of G* to one SM top or bottom quark plus its heavy partner. We find that
at \sqrt{s} = 7 TeV and with 10 fb^{-1} of integrated luminosity, the LHC can
discover a KK gluon with mass in the range M_{G*} = (1.8 - 2.2) TeV if its
coupling to a pair of light quarks is g_{G*qqbar} = (0.2-0.5) g_3. The same
process is also competitive for the discovery of the top and bottom partners as
well. We find, for example, that the LHC at \sqrt{s} = 7 TeV can discover a 1
TeV KK bottom quark with an integrated luminosity of (5.3 - 0.61) fb^{-1} for
g_{G*qqbar} = (0.2-0.5) g_3.Comment: 36 pages, 13 figures. v2: a few typos corrected, comments added,
version published in JHE
New Higgs Production Mechanism in Composite Higgs Models
Composite Higgs models are only now starting to be probed at the Large Hadron
Collider by Higgs searches. We point out that new resonances, abundant in these
models, can mediate new production mechanisms for the composite Higgs. The new
channels involve the exchange of a massive color octet and single production of
new fermion resonances with subsequent decays into the Higgs and a Standard
Model quark. The sizable cross section and very distinctive kinematics allow
for a very clean extraction of the signal over the background with high
statistical significance. Heavy gluon masses up to 2.8 TeV can be probed with
data collected during 2012 and up to 5 TeV after the energy upgrade to
TeV.Comment: 27 pages, 22 figures. V2: typos corrected, matches published versio
Partial complementation of Sinorhizobium meliloti bacA mutant phenotypes by the Mycobacterium tuberculosis BacA protein
The Sinorhizobium meliloti BacA ABC transporter protein plays an important role in its nodulating symbiosis with the legume alfalfa (Medicago sativa). The Mycobacterium tuberculosis BacA homolog was found to be important for the maintenance of chronic murine infections, yet its in vivo function is unknown. In the legume plant as well as in the mammalian host, bacteria encounter host antimicrobial peptides (AMPs). We found that the M. tuberculosis BacA protein was able to partially complement the symbiotic defect of an S. meliloti BacA-deficient mutant on alfalfa plants and to protect this mutant in vitro from the antimicrobial activity of a synthetic legume peptide, NCR247, and a recombinant human \u3b2-defensin 2 (HBD2). This finding was also confirmed using an M. tuberculosis insertion mutant. Furthermore, M. tuberculosis BacA-mediated protection of the legume symbiont S. meliloti against legume defensins as well as HBD2 is dependent on its attached ATPase domain. In addition, we show that M. tuberculosis BacA mediates peptide uptake of the truncated bovine AMP, Bac71-16. This process required a functional ATPase domain. We therefore suggest that M. tuberculosis BacA is important for the transport of peptides across the cytoplasmic membrane and is part of a complete ABC transporter. Hence, BacA-mediated protection against host AMPs might be important for the maintenance of latent infections
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