Efficacy and safety of thrombolytic therapy in prosthetic valve thrombosis

Background: There is limited data available about the effectiveness of thrombolysis in prosthetic valve thrombosis (PVT). Therefore, this study aimed to evaluate the efficacy and safety of thrombolytic treatment in PVT patients.Methods: This was an observational study conducted at a tertiary-care centre in India between March 2013 and April 2014. Total of 56 patients with either recurrent PVT or with confirmed left-sided PVT was included in the study. Thrombolytic therapy was administered as an intravenous infusion of streptokinase or urokinase, initially at a loading dose of 2.5L IU/hour over 30 minutes, followed by 1L IU/hour for 48–78 hours depending upon the clinical and 2D-Echo observation. Primary endpoint was considered as the occurrence of a complete clinical response. Secondary endpoint was considered as a composite of death, major bleeding or embolic stroke.Results: Mean age of the patients was 37±13 years. Most of the patients presented with NYHA-II (51.7%), III (39.2%), and IV (8.9%) symptoms. Mitral and aortic valve thrombosis were observed in 40(71.4%) and 11(28.6%) patients. Forty-nine (73.3%) patients were treated with streptokinase. Whereas, rethrombosis patients were treated with urokinase [6(16%)] and tenecteplase [1(1.3%)]. Two (3.6%) patients died, 1(1.8%), 1(1.8%), 2(3.6%), and 1(1.8%) patient had peripheral embolism, central nervous system bleeding, stroke, and embolic complications.Conclusions: Thrombolytic therapy can be used as the first-line treatment for thrombolysis in PVT patients. All PVT patients can be treated with streptokinase unless specific contraindications exist. Urokinase or tenecteplase is an alternative thrombolytic agent in rethrombosis patients

INLINE ELASTICITY MEASURE OF TEXTILE USING ANN

In this paper, we propose a technique to measure the Elasticity Modulus of the textile material using flex LVDT. Elasticity modulus is measured indirectly by measuring stiffness of the material first. The material whose stiffness is to be measured is subjected to a known force and the deflection caused in the material due to applied load is measured using the LVDT. Here the whole measurement is done dynamically without halting the manufacturing line of process. The output of LVDT is AC voltage. AC-DC converter is used to convert the AC output voltage of LVDT to DC output voltage. This is cascaded to the ANN block programmed on the LabVIEW platform. The results show that the proposed technique has achieved its proposed objectives

Transformer less Series Active Filter for Power Quality Improvement

- To upgrade the power quality in single-stage frameworks with critical loads a transformer less hybrid series dynamic channel is proposed . This venture helps the energy administration and power quality issues identified with electric transportation and spotlights on enhancing electric vehicle load association with the grid. The control technique is intended to counteract current harmonic bends of nonlinear loads to stream into the utility and rectifies the power element of this later. While shielding sensitive loads from voltage disturbance influences, droops, and swells started by the power framework, ridded of the arrangement transformer, the design is invaluable for a mechanical usage. This polyvalent half and half topology permitting the symphonious separation and pay of voltage bends could ingest or infuse the assistant energy to the grid. The aggregate consonant bending is decreased with the adequacy of the fluffy controller. This venture additionally examines on the impact of increases and postponements in the continuous controller dependability. The simulation result  brought out through MATLAB/SIMULINK programming

Low Frequency Modular Multilevel Converter Topology for Improved Dynamic Performance of Variable-Speed AC Drives

This venture shows a control conspire for the particular multilevel converter (MMC) to drive a variable-speed air conditioning machine, particularly concentrating on enhancing dynamic execution. Hypothetically, the vitality adjust in the MMC cell capacitors is inclined to be unsteady at start-up and low-recurrence operations. Also, the MMC topology basically requires propelled control methodologies to adjust vitality and stifle the voltage throb of every phone capacitor. This venture proposes a control methodology for the powerful unique reaction of MMC even at zero yield recurrence utilizing leg balance voltage infusion. The leg counterbalance voltage for adjusting the arm vitality is delivered by direct figuring without the coursing current control circle controller. On account of the exceedingly unique leg balance voltage from direct computation and not traditional circling current controller, the dynamic execution of a MMC at low speeds has obviously made strides. The air conditioner machine has been driven from halt to evaluated speed without exorbitant cell capacitor voltage swells using this proposed technique. The reproduction comes about check that steady operation is ensured down to <2% of the evaluated speed under 40% stage stack torque unsettling influence. The size of converter yield voltages are expanded, utilizing fluffy controller. The outcomes were broke down in MATLAB/SIMULINK condition

An Enhanced IUPQC Controller to Provide Grid Voltage Regulation

This paper shows an enhanced controller for the double topology of the brought unified power quality conditioner (iUPQC) developing its materialness in power-quality remuneration, and additionally in smaller scale network applications. By utilizing this controller, past the traditional UPQC control quality components, including voltage list/swell remuneration, the iUPQC will likewise give responsive power support to manage the load-bus voltage as well as the voltage at the matrix side bus.A FUZZY controller is executed in this venture in the place of PI controller. IUPQC will fill in as a static synchronous compensator (STATCOM) at the network side, while giving likewise the routine UPQC pay at the heap or small scale framework reproduction results are given to check the new usefulness of the hardware. Reenactment results are introduced to confirm the practicality of the proposed approach in MATLAB/SIMULINK condition.

Spiny Lobsters and Potential of Sea Cage Culture Spiny Lobster Resources in India

Fishery science and technology contributes a vital role in the augmentation of fish production globally.Among the seafood items, spiny lobsters have a prime position in terms of high unit value, demand, nutritional qualities with less perishable nature. Lobsters have great demand in international and domestic market, especially from tourism based beach resorts and restaurants as a luxury food. The annual lobster landings in India has been declining from a peak of 4,075 t in 1985 to the present annual average of 1,546 t. On an average, the fishery is contributed by Gujarat (43.7%), Maharashtra (25.4%), Tamil Nadu(14.6%) and Kerala (13%) (CMFRI Annual Report 2000-2015). Lobster fishing in India is mostly carried out by region specific traditional fishermen communities inhabiting along the coastal belts of different maritime states. Over the years the lobster fishery in India witnessed changes in fishing pattern, utility pattern with the introduction of live export market , sea cage culture and increased consumption and demand from tourism sector . Live Lobsters have a prominent place in the sea food export market both in terms of demand and price from Japan, Korea, China, Taiwan, Europe and USA. India witnessed a sea change in foreign exchange earnings through marine products export worth 46,975 million rupees during 1997-98 and 55,111.12 million rupees during 2014-15, from an initial value of 25 million rupees in 1950-51 (Sakthivel, 1999). The marine products export accounted and contributed 3.5 % of the total exports in 1990s. Our marine product exports in the initial stages were in dried and canned form. It has gradually progressed into frozen h 340 million rupees in 1996-97 (Sakthivel, 1999). Spiny lobsters formed one of the items in the live fish export along with mud crabs and reef fishes. The annual average revenue earnings by India through the export of lobsters is amounted to Rs.74 crores

EVALUATION OF A METHOD FOR DETECTION OF BOTH METALLO BETALACTAMASE (MBL) AND EFFLUX PRODUCTION USING CARBONYL CYANIDE 3-CHLOROPHENYLHYDRAZONE (CCCP)±COMBINATION METHOD AMONG PSEUDOMONAS AERUGINOSA ISOLATED FROM CLINICAL SPECIMENS

Objective: To standardize a method for the differential detection of Metallo Betalactamase (MBL) production and efflux pump mechanism using Carbonyl Cyanide 3-ChloroPhenylhydrazone (CCCP) among the clinical isolates of Pseudomonas aeruginosa recovered from ocular specimens.Methods: A total of 110 clinical isolates of Pseudomonas aeruginosa were plated onto Muller-Hinton agar (MHA) plate with CCCP and without CCCP. Carbapenems-Ethylenediaminetetraacetic acid (EDTA) combination disk method was performed on CCCP± plates for individual isolates and the results were compared.Results: Out of 110 clinical isolates of P aeruginosa studied, 11(10%) were tested positive for MBL Production by carbapenem-EDTA combination test/CCCP-test. In which, six isolates showed positive for both efflux and MBL production using CCCP+plate and 5 isolates showed positive only for MBL production.Conclusion: The current study standardized a method for detecting both MBL and efflux mechanism in a single plate consists of CCCP± plate containing antibiotic disk with and without EDTA. Implication of this method in routine diagnostics will help the clinicians to treat the patient with appropriate drug choice and dosage.Â

Length-weight, length-length relationships and condition factor of obtuse barracuda Sphyraena obtusata Cuvier, 1829 (Pisces: Perciformes) from Vizhinjam coast, Kerala, India

Eleven morphometric variables including weight were recorded for 429 specimens of obtuse barracuda Sphyraena obtusata Cuvier, 1829 collected over a period of two years from January 2017 to December 2018, from Vizhinjam fish landing centre, Thiruvananthapuram, Kerala. Length-weight relationship and length-length relationship of the species were estimated using linear regression analysis. Different length measurements were converted to ratios with standard length as morphometric ratios and the growth rate was assessed gender wise. Length-weight relationship for male and female population were estimated as Wm= 13.326 × L3.2409 and Wf = 11.952 × L2.9821, respectively. Linear relationships for other morphometric variables and morphometric ratios with standard length were established for the species. Principal component analysis was performed and total length, snout length and snout to pre-nostril length were identified as key morphometric variables discriminating gender. The relative condition factor was estimated as 1.04+0.13 for total population and the role of morphometric ratios in sex differentiation was examined

Observation of spin glass state in weakly ferromagnetic Sr2_2FeCoO6_6 double perovskite

We report the observation of spin glass state in the double perovskite oxide Sr$_{2}$FeCoO$_{6}$ prepared through sol-gel technique. Initial structural studies using x rays reveal that the compound crystallizes in tetragonal $I 4/m$ structure with lattice parameters, $a$ = 5.4609(2) \AA and $c$ = 7.7113(7) \AA. The temperature dependent powder x ray studies reveal no structural phase transition in the temperature range 10 -- 300 K. However, the unit cell volume shows an anomaly coinciding with the magnetic transition temperature thereby suggesting a close connection between lattice and magnetism. Neutron diffraction studies and subsequent bond valence sums analysis show that in Sr$_{2}$FeCoO$_{6}$, the $B$ site is randomly occupied by Fe and Co in the mixed valence states of Fe$^{3+}$/Fe$^{4+}$ and Co$^{3+}$/Co$^{4+}$. The random occupancy and mixed valence sets the stage for inhomogeneous magnetic exchange interactions and in turn, for the spin glass like state in this double perovskite which is observed as an irreversibility in temperature dependent dc magnetization at $T_f\sim$ 75 K. Thermal hysteresis observed in the magnetization profile of Sr$_{2}$FeCoO$_{6}$ is indicative of the mixed magnetic phases present. The dynamic magnetic susceptibility displays characteristic frequency dependence and confirms the spin glass nature of this material. Dynamical scaling analysis of $\chi'(T)$ yields a critical temperature $T_{ct}$ = 75.14(8) K and an exponent $z\nu$ = 6.2(2) typical for spin glasses. The signature of presence of mixed magnetic interactions is obtained from the thermal hysteresis in magnetization of Sr$_{2}$FeCoO$_{6}$. Combining the neutron and magnetization results of Sr$_2$FeCoO$_6$, we deduce the spin states of Fe to be in low spin while that of Co to be in low spin and intermediate spin.Comment: 23 pages, 6 figures, accepted in J. Appl. Phy