6 research outputs found
Glucose-6-Phosphate Dehydrogenase Deficiency in an Endemic Area for Malaria in Manaus: A Cross-Sectional Survey in the Brazilian Amazon
BACKGROUND: There is a paucity of information regarding glucose-6-phosphate dehydrogenase (G6PD) deficiency in endemic areas for malaria in Latin America. METHODOLOGY/PRINCIPAL FINDINGS: This study determined the prevalence of the G6PD deficiency in 200 male non-consanguineous individuals residing in the Ismail Aziz Community, on the outskirts of Manaus (Brazilian Amazon). Six individuals (3%) were deficient using the qualitative Brewer's test. Gel electrophoresis showed that five of these patients were G6PD A(-). The deficiency was not associated with the ethnic origin (P = 0.571). In a multivariate logistic regression analysis, G6PD deficiency protected against three or more episodes of malaria (P = 0.049), independently of the age, and was associated with a history of jaundice (P = 0.020) and need of blood transfusion (P = 0.045) during previous treatment for malarial infection, independently of the age and the previous malarial exposure. CONCLUSIONS/SIGNIFICANCE: The frequency of G6PD deficiency was similar to other studies performed in Brazil and the finding of a predominant G6PD A(-) variant will help the clinical management of patients with drug-induced haemolysis. The history of jaundice and blood transfusion during previous malarial infection may trigger the screening of patients for G6PD deficiency. The apparent protection against multiple malarial infections in an area primarily endemic for Plasmodium vivax needs further investigation
Associação de metemoglobinemia e deficiência de glicose-6-fosfato desidrogenase em pacientes com malária tratados com primaquina
Associação de metemoglobinemia e deficiência de glicose-6-fosfato desidrogenase em pacientes com malária tratados com primaquina
Este estudo teve como objetivo verificar a ocorrência de metemoglobinemia em indivÃduos deficientes da glicose-6-fosfato desidrogenase durante o tratamento da infecção malárica com primaquina. Foram selecionados pacientes com diagnóstico para malária por Plasmodium vivax ou mista V+F (Plasmodium vivax + Plasmodium falciparum), Grupo 1: com 74 indivÃduos com diagnóstico clÃnico de metemoglobinemia e Grupo 2: 161 indivÃduos sem diagnóstico clÃnico de metemoglobinemia. Quanto à deficiência da G6PD, nos Grupos 1 e 2, houveram 51,3% (38) e 8,7% (14) de indivÃduos enzimopênicos, respectivamente, demonstrando através de tais dados, significância estatÃstica na associação com a metemoglobinemia somente nos indivÃduos do Grupo 1 (p<0,05). A comparação da relação da metemoglobinemia à deficiência da G6PD mostrou haver uma possÃvel associação de indivÃduos enzimopênicos desenvolverem metemoglobinemia com maior freqüência
Crude <i>odds ratios</i> and respective CI95% in the univariate logistic regression analysis of the association between G6PD deficiency and ethnic origin, previous malaria exposure and previous clinical complications triggered by malarial infection.
*<p>χ<sup>2</sup>-test.</p>**<p>Fisher exact test.</p
Adjusted <i>odds ratios</i> and respective CI95% for the variables associated with G6PD deficiency in multiple logistic-regression models.
*<p>Modified Wilcoxon test for trend.</p>**<p>Model 1: adjusted for age.</p>***<p>Model 2: adjusted for age and previous malarial exposure.</p
Geographic localization of the Ismail Aziz Community in an endemic area for malaria in Manaus, Amazonas State, Brazil.
<p>Geographic localization of the Ismail Aziz Community in an endemic area for malaria in Manaus, Amazonas State, Brazil.</p