Triglyceride glucose index reflects the unfavorable changes of left ventricular diastolic functions and structure in uncomplicated newly diagnosed hypertensive patients

Introduction Left ventricular (LV) diastolic dysfunction and structural abnormalities are common cardiac changes in hypertension (HTN), and several factors other than high blood pressure (BP) may play a role in these changes. The aim of this study was to reveal the relationship between triglyceride glucose (TyG) index, a novel parameter for insulin resistance (IR), with LV diastolic function and structure in hypertensive patients. Material and method A total of 119 newly diagnosed, untrated hypertensive patients free of diabetes and/or cardiovascular complications were included in this study. IR was estimated with the TyG index calculated from ln [fasting TG (mg/dL) x fasting blood glucose (mg/dL)/2]. Two-dimensional and Doppler echocardiographic examinations were performed to assess LV diastolic functions and structure. Results Based on median TyG index, 51 patients was assigned as group I (8.7). In patients with high TyG index, left atrial volume index (LAVi) (p .05). Stepwise multiple regression analysis demonstrated that the relationship of TyG index with LV diastolic function and structure was independent of potential confounders (all p < .001). Conclusion This study suggest that a high TyG index is related to LV diastolic functional impairment and structure abnormality in newly diagnosed hypertensive patients in the absence of diabetes or CVD

The evaluation of the newly defined CHA2DS2-VASc-HSF score in the severity of coronary artery disease and short-term prognosis CHA2DS2-VASc-HSF score and coronary artery disease

Aim: In this study, we aimed to evaluate the ability of the CHA2DS2-VASc-HSF score to predict short-term prognosis in acute coronary syndrome (ACS) patients. Material and Methods: A total of 167 patients who underwent coronary angiography were included in this retrospective study. The patients were divided into two groups according to CHA2DS2-VASc-HSF: the low-score group (a 4 points) and the high score group (> 4 points). Primary and secondary endpoints were defined. CHA2DS2-VASc and GRACE scores were calculated, and the severity of coronary artery disease (CAD) was evaluated using SYNTAX I score (SSI). Results: Patients in the high score group had increased CHA2DS2-VASc, GRACE scores and SSI. Also, in-hospital death and MACE within 30 days were more common in this group. There was a strong correlation between the CHA2DS2-VASc-HSF score and SSI (r=0.825, p0.001). In the ROC analysis, CHA2DS2VASc-HSF predicted in-hospital death and MACE within 30 days with cut off value 5.5 and 4.5, respectively (AUC=0.803. p0.001; AUC= 0.877, p0.001). In multivariate binary logistic regression analysis, CHA2DS2-VASc-HSF, CHA2DS2-VASc, GRACE and age were independent predictors of short-term prognosis. Discussion: We evaluated the role of the CHA2DS2-VASc-HSF score in CAD severity and short-prognosis, and we agree that this new score can be used to predict CAD severity and short-term prognosis in patients presenting with ACS

Retinol binding protein 4 levels relate to the presence and severity of coronary artery disease

Background: The previous studies have showed that serum retinol binding protein 4 (RBP4) levels increase in metabolic disorders which are closely associated with cardiovascular diseases (CVD). However, the human studies investigating the role of RBP4 in CVD are conflicted. Therefore, we aimed to evaluate the relationship between RBP4 with the presence and severity of coronary artery disease (CAD) in this study. Methods: 55 patients with presenting acute coronary syndrome (ACS) and 43 control subjects who had various cardiovascular risk factors with normal coronary artery on coronary angiography were included in this study. The serum RBP4 concentrations were measured using ELISA method, clinically and anatomically score models were used to assess the severity of coronary lesion. Results: Serum RBP4 levels were significantly higher in patients with ACS compared to the without ACS (68.40 +/- 47.94 mg/L vs. 49.46 +/- 13.64 mg/L; p = 0.014). RBP4 was correlated with GENSINI and SYNTAX I score (r = 0.286 p = 0.034; r = 0.403 p = 0.002 respectively). However, there was no relationship between RBP4 and GRACE score. Conclusions: The serum RBP4 levels increase in patients with CAD and its increased levels may be correlated with CAD severity

Relationship between circulating serum omentin-1 levels and nascent metabolic syndrome in patients with hypertension

The prevalence of metabolic syndrome (MetS) is more common in patients with hypertension and is associated with an increased risk of target organ damage and/or cardiovascular disease (CVD). Omentin-1 is a beneficial adipokine considered to play a role in MetS and MetS-related states such as obesity, diabetes, and coronary artery disease. The aim of this study was to determine the relationship between circulating omentin-1 levels and MetS uncomplicated by diabetes or CVD (nascent MetS) in patients with hypertension. In this study, 110 patients (54 men, 49%; average age: 49.72 +/- 11.32 years) treated for hypertension but without overt diabetes and/or CVD were enrolled. 66 patients were stratified into MetS (+) (group 1) and 44 patients into MetS (-) (group 2) according to the American Heart Association/National Heart, Lung, and Blood Institute criteria. The triglyceride glucose (TyG) index was used to assess insulin resistance. Circulating omentin-1 levels in venous blood samples were measured by an ELISA kit. Circulating omentin-1 levels in patients with MetS were significantly lower than in patients without MetS (46.35 ng/mL (42.70-57.70 ng/mL) vs 130.95 ng/mL (62.83-236.48 ng/mL), p0.001). Omentin-1 was inversely correlated with TyG index (r=-0.204, p=0.033). In a multivariate logistic regression analysis, omentin-1, TyG index, and body mass index were independent predictors of MetS. A receiver operating characteristic curve analysis determined that the best cut-off value for omentin-1 in predicting MetS was 62.20 ng/mL and the area under the curve was 0.880 (95% CI 0.817 to 0.942, p0.001). The findings of this study suggest that circulating omentin-1 levels are inversely related to the presence of MetS and may be a reliable marker to predict the development of MetS in patients with hypertension

Chitotriosidase enzyme can be a negative acute phase protein in acuteheart failure unlike coronary artery diseases [2016]

Introduction: Heart Failure (HF) is a complex, neurohumoral and inflammatory syndrome. Recent studies show that proinflammatory cytokines contribute heart’s systolic or diastolic dysfunction causing cardiac depression. Chitotriosidase (CHIT), an enzyme released from active macrophages, plays a role in many diseases involving inflammation. Therewithal, it has been observed that CHIT activity in plasma is significantly high in ischemic heart diseases with arterial inflammation. This thesis aims to figure out the role of CHIT in HF and the relationship between other cytokines. Method: 43 Newyork Heart Association (NYHA) class III/IV acute heart failure (AHF) patients who were hospitalized in the coronary intensive care unit (CICU), 48 chronic heart failure (CHF) patients and 45 healthy controls included in the study. All participants’ detailed echocardiography, doppler and tissue doppler measurements were performed and left ventricular ejection fractions (LVEF) were calculated by Simpson method. All participants’ plasma CHIT IL-1??????, TNF??????, IL-6, Hs-CRP and NT-proBNP levels were determined by ELISA method. Results: The lowest CHIT activity in plasma (527,876±323,04 ng/ml) is detected in AHF patients. It was observed that when LVEF of acute heart failure patients decrease their CHIT activity levels decrease as well. Also a negative correlation (p=0,038 and r=-0,32) occurred between CHIT activity levels and NYHA class levels in AHF patients. Conclusion: CHIT enzyme may play a role as a negative acute phase protein in AHF. Plasma CHIT value of AHF patients decreases when left ventricular systolic dysfunction increases and it is negatively correlated with NYHA values

ELEVATED TRIGLYCERIDE GLUCOSE INDEX IS RELATED TO THE PRESENCE OF HEART FAILURE

Objective: Previous studies have shown a significant associa-tion between insulin resistance (IR) measured by using different methods and heart failure (HF). In recent years, the triglyceride glucose (TyG) index has been used to measure IR, and there are several reports showing that the TyG index indicates conditions such as metabolic syndrome (MetS) and atherosclerotic process. However, there is no study investigating the association of the TyG index with HF. Therefore, we aimed to evaluate the role of the TyG index in HF presence and its relationship with HF sever-ity in this study

IS SERUM FIBROBLAST GROWTH FACTOR 21 ASSOCIATED WITH THE SEVERITY OR PRESENCE OF CORONARY ARTERY DISEASE?

Background: Recent studies have shown that increased circulating concentrations of fibroblast growth factor 21 (FGF21) are associated with obesity, metabolic disorder, and atherosclerosis. However the relationship between FGF21 and coronary artery disease (CAD) is controversial This study was planned to investigate the role of FGF21 in CAD development and CAD severity