Endoscopy in the Diagnosis of Small Intestinal Tumors

The importance of endoscopy in the diagnosis of small intestinal tumors was evaluated in 15 patients with small intestinal tumors treated in our hospital. Two tumors were benign, and 13 were malignant (carcinoma in 5 patients, malignant lymphoma in 5 and leiomyosarcoma in 3). The presence of lesions could be determined by X-rays before surgery, but definitive diagnoses were difficult. When preoperative endoscopy of the small intestine was possible accurate preoperative diagnoses could be made based on the endoscopic findings and biopsies taken under direct vision. Endoscopy is therefore very important for the diagnosis of small intestinal tumors. It is necessary to develop small intestinal endoscopes that are easier to insert

Burnout and fear of COVID-19 among medical students in Japan: impact of infection history, gender, and social support

The COVID-19 pandemic caused significant changes in medical students' lives and study methods, with online learning replacing in-person classes and limited opportunities for clinical practice. However, there are few studies about burnout and fear of COVID-19 among medical students, especially in East Asia, and a need for research investigating the impact of gender, a history of COVID-19 infection, and social support. In March 2022, we conducted a cross-sectional web-based survey of 4th/5th year medical students who completed a clinical clerkship in Japan. Our survey included the Japan Burnout Scale (JBS, range 5-85, comprising of emotional exhaustion, depersonalization and reduced personal accomplishment), fear of COVID-19 scale (range, 1-4), gender, school year, COVID-19 history, household composition, online education use, and financial burden. There were 343 respondents and 42.4% were women. Multivariable adjusted linear regression analyses showed that students with a COVID-19 infection history had significantly higher overall burnout, depersonalization, reduced personal accomplishment, and lower fear of COVID�19. Students with low social support (living alone and greater financial burden) had higher overall burnout, emotional exhaustion, and depersonalization. Gender had no significant effect on burnout (mean JBS among women was 38.6 versus 39.3 among men). Gender significantly predicted fear of COVID-19, with women scoring higher (1.60 versus 1.50). The findings of the present study have implications that medical schools should provide pastoral care for their students according to students’ circumstances, especially those who live alone, have a high financial burden, and/or were infected with COVID-19

High-level production of violacein by the newly isolated Duganella violaceinigra str. NI28 and its impact on Staphylococcus aureus

A violacein-producing bacterial strain was isolated and identified as a relative of Duganella violaceinigra YIM 31327 based upon phylogenetic analyses using the 16S rRNA, gyrB and vioA gene sequences and a fatty acid methyl ester (FAME) analysis. This new strain was designated D. violaceinigra str. NI28. Although these two strains appear related based upon these analyses, the new isolate was phenotypically different from the type strain as it grew 25% faster on nutrient media and produced 45-fold more violacein. When compared with several other violacein producing strains, including Janthinobacterium lividum, D. violaceinigra str. NI28 was the best violacein producer. For instance, the crude violacein yield with D. violaceinigra str. NI28 was 6.0 mg/OD at 24 hours, a value that was more than two-fold higher than all the other strains. Finally, the antibacterial activity of D. violaceinigra str. NI28 crude violacein was assayed using several multidrug resistant Staphylococcus aureus. Addition of 30 mu M crude violacein led to a 96% loss in the initial S. aureus population while the minimum inhibitory concentration was 1.8 mu M. Consequently, this novel isolate represents a phenotypic variant of D. violaceinigra capable of producing much greater quantities of crude violacein, an antibiotic effective against multidrug resistant S. aureusopen

The Synthesis, Self-Assembly and Self-Organisation of Polysilane Block Copolymers

Block copolymers containing polysilane blocks are unique in that the polysilane components possess electro-active properties and are readily photodegradable. This review will discuss and assess the two major approaches to the synthesis of polysilane block copolymers via pre-formed polymer chain coupling and living polymerisation techniques. The self-organisation of polysilane block copolymers and the morphologies adopted in thin films are reviewed. Amphiphilic polysilane-containing block copolymers self-assemble in solvents selective for one block and a number of examples are highlighted. The versatility of these materials is highlighted by recent significant applications including the preparation of hollow crosslinked micellar aggregates in aqueous solutions and in patterned thin film generation subsequently employed as templates for the growth of cell cultures and CaCO (3.