Correlation of Body Mass Index and Disease Activity Score (DAS-28) in Patients with Rheumatoid Arthritis

Background: Rheumatoid Arthritis (RA) is the most common autoimmune disease. RA can cause permanent deformity and loss of productivity. The primary objective of the study was to evaluate the relationship of BMI with Disease Activity Score in RA patients. The secondary objective was to evaluate the presence of comorbidities such as diabetes, thyroid, hypertension, periodontitis, and pregnancy outcomes (in the case of females) in the RA patients population presented at the tertiary healthcare centre. Method: The presented study was a cross-sectional study. 100 Patients presented to the joint clinic were recruited. RA diagnosis of patients was based on the ACR/ELULAR criteria. Their demographic and clinical data was collected through one-on-one interviews. Results: The recruited population shows that BMI has a moderate positive correlation (r=0.347, p=0.001) with disease activity scores. 51% of RA patients have one or more comorbidities. 45.2 % of female RA patients suffered one or two miscarriages during their pregnancy. It is significantly higher as compared normal female population. Conclusions: Active control of BMI may be required to prevent RA symptom aggravation. RA patients are prone to develop comorbidities and females with RA may need close monitoring during their pregnancy period

Association of disease activity score (DAS) 28 with subsets of rheumatoid factor and anti-cyclic citrullinated peptides (anti-CCP) among rheumatoid arthritis patients in North India

297-302Rheumatoid factor (RF), anticyclic citrullinated peptides (Anti-CCP), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) are used as disease markers for rheumatoid arthritis (RA). However, correlation of disease activity score (DAS) 28 with autoantibodies and inflammatory markers has not been studied in detail. Here, we have made an attempt to determine the association of DAS-28 with autoantibodies and inflammatory markers among the North Indian population. Further, we investigated the potential of subsets of autoantibodies in RA diagnosis. Disease activity was calculated by DAS-28-ESR calculator and levels of disease markers were estimated in serum. We noticed positive correlation between DAS-28, CRP (r=0.63, p=0.00) and ESR (r=0.72, p=0.00). Moderate and weak correlation was found with RF (r=0.41, p=0.00) and anti-CCP (r=0.25, p=0.011), respectively. Patients with positive subsets of both autoantibodies (RF+/Anti-CCP+) have shown a positive correlation with DAS-28. In our study, we found that the presence of RF and Anti-CCP in patient sera can increase the early detection rate of disease. But, for the diagnosis of disease in seronegative patients, more studies on biomarkers are required

PBMC miRNA in diagnosis of rheumatoid arthritis: A miRNA expression analysis study

Background and objective: RA is an autoimmune disorder mediated by autoantibodies. miRNAs have been shown to negatively regulate protein translation via an antisense RNA-RNA interaction. Altered miRNA expression has been well established in autoimmune diseases. In this study, the expression of four microRNA was analysed. Also, correlation between microRNA and immunological markers was examined. Method:  RNA was isolated from PBMC obtained from 100 RA patients and age-gender matched healthy controls. Levels of mature miRNA of miR146a, miR155a, miR499 and miR124a were detected using real time PCR. Downstream cytokine was analysed using ELISA from R&D systems. Result:  Real time PCR reveals that the expression of miR-146a, miR-155a, miR-499 in PBMC was found to be down regulated in RA patients when compared to the controls by fold change of 0.15, 0.69 and 0.04 respectively whereas, expression of miR124a was found to be low to detect.  Expression of TNF- alpha upregulated (p-value=0.09) and IL6 was found to be insignificantly down regulated in patient. miRNA 155a was found to be in significant negative correlation with rheumatoid factor (r= -0.210; p=0.038).&nbsp

Abstracts of International Conference on Innovations in Business Management

This book contains abstracts of the various research ideas of the academic community and practitioners of management presented at the International Conference on Innovations in Business Management (ICIBM 2020). The researchers have contributed toward various themes of the conference such as sustainable economy, supply chain, women-empowerment, export-import, microfinance, government policies, etc. We strongly believe that it will open up further scope for in-depth research in various disciplines of business management. Best wishes to the participants to have detailed discussions on the above-said wide range of areas. Conference Title: International Conference on Innovations in Business ManagementConference Acronym: ICIBM 2020Conference Date: 16-17 January 2020Conference Location: ICFAI University, Dehradun, IndiaConference Organizers: ICFAI Business School, ICFAI University, Dehradun, India & University of Derby, United Kingdo