幼若動物組織浸出液(血液)の微生物發育に及ぼす影響

Embedded adaptive interventions in the SMART design of Figs. 1 and 2. Table S1. Eight embedded adaptive interventions in the SMART design of Fig. 1. Table S2. Four embedded adaptive interventions in the SMART design of Fig. 2, word document. (DOCX 14 kb

Multiplicative changes in -values with genomic control in Affymetrix dataset

<p><b>Copyright information:</b></p><p>Taken from "Effects of population structure on genetic association studies"</p><p></p><p>BMC Genetics 2005;6(Suppl 1):S109-S109.</p><p>Published online 30 Dec 2005</p><p>PMCID:PMC1866830.</p><p></p

A Linkage Disequilibrium–Based Approach to Selecting Disease-Associated Rare Variants

<div><p>Rare variants have increasingly been cited as major contributors in the disease etiology of several complex disorders. Recently, several approaches have been proposed for analyzing the association of rare variants with disease. These approaches include collapsing rare variants, summing rare variant test statistics within a particular locus to improve power, and selecting a subset of rare variants for association testing, e.g., the step-up approach. We found that (a) if the variants being pooled are in linkage disequilibrium, the standard step-up method of selecting the best subset of variants results in loss of power compared to a model that pools all rare variants and (b) if the variants are in linkage equilibrium, performing a subset selection using step-based selection methods results in a gain of power of association compared to a model that pools all rare variants. Therefore, we propose an approach to selecting the best subset of variants to include in the model that is based on the linkage disequilibrium pattern among the rare variants. The proposed linkage disequilibrium–based variant selection model is flexible and borrows strength from the model that pools all rare variants when the rare variants are in linkage disequilibrium and from step-based selection methods when the variants are in linkage equilibrium. We performed simulations under three different realistic scenarios based on: (1) the HapMap3 dataset of the DRD2 gene, and CHRNA3/A5/B4 gene cluster (2) the block structure of linkage disequilibrium, and (3) linkage equilibrium. We proposed a permutation-based approach to control the type 1 error rate. The power comparisons after controlling the type 1 error show that the proposed linkage disequilibrium–based subset selection approach is an attractive alternative method for subset selection of rare variants.</p></div

LD structure for block LD simulated data in scenario 2.

<p>The orange blocks contain 10 variants each, which are in LD with one another. Two red variants in each block were randomly designated as the causal variants. The rest of the variants are independent of all the other variants.</p

Power comparison for different approaches at the 5% and 1% levels of significance for simulation scenario 3, where all the variants were in linkage equilibrium.

<p>Power comparison for different approaches at the 5% and 1% levels of significance for simulation scenario 3, where all the variants were in linkage equilibrium.</p

Power comparison for different approaches at the 5% and 1% levels of significance.

<p>The first panel corresponds to simulation scenario 1 using the LD structure of the DRD2 gene and the second panel corresponds to simulation scenario 1 using the LD structure of the CHRNA3/A5/B4 gene cluster.</p

The Litvinenko case and its reflection in The Daily Telegraph

This bachelor thesis studies the manner in which the case of the former Russian spy Alexander Litviněnko's poisoning was handled in 2006 by the British newspaper The Daily Telegraph. Both quantitative and qualitative analyses have been used for that purpose. The theoretical part of the thesis explains the factors influencing the process of encoding of the meanings into mediated contents, and the process of their subsequent decoding by the public. The analytical part presents a detailed description of how the concrete news texts on the Litvinenko case published by The Daily Telegraph could have been perceived by their recipient. Hypotheses have been set for the analysis; the confirmation or denial of their validity outlines The Daily Telegraph's methods of news reporting production and the terms in which the news texts are conceived in this newspaper

District-specific dengue incidence intensity map in 2015 Tainan.

<p>District-specific dengue incidence intensity map in 2015 Tainan.</p

Daily dengue incidence data for North District, Tainan city, Taiwan, from August to October, 2015.

<p>Daily dengue incidence data for North District, Tainan city, Taiwan, from August to October, 2015.</p

Seeking gene relationships in gene expression data using support vector machine regression-4

The gene pool hit a group of genes that formed set A. The pathway reconstruction was done using 4.0 (Ariadne Genomics, Inc.).<p><b>Copyright information:</b></p><p>Taken from "Seeking gene relationships in gene expression data using support vector machine regression"</p><p>http://www.biomedcentral.com/1753-6561/1/S1/S51</p><p>BMC Proceedings 2007;1(Suppl 1):S51-S51.</p><p>Published online 18 Dec 2007</p><p>PMCID:PMC2367560.</p><p></p