Stretching of a single-stranded DNA: Evidence for structural transition

Recent experiments have shown that the force-extension (F-x) curve for single-stranded DNA (ssDNA) consisting only of adenine [poly(dA)] is significantly different from thymine [poly(dT)]. Here, we show that the base stacking interaction is not sufficient to describe the F-x curves as seen in the experiments. A reduction in the reaction co-ordinate arising from the formation of helix at low forces and an increase in the distance between consecutive phosphates of unstacked bases in the stretched state at high force in the proposed model, qualitatively reproduces the experimentally observed features. The multi-step plateau in the F-x curve is a signature of structural change in ssDNA.Comment: 10 pages, 4 figure

Isospin asymmetry and type-I superconductivity in neutron star matter

It has been argued by Buckley et. al.(Phys. Rev. Lett. 92, 151102, 2004) that nuclear matter is a type-I rather than a type-II superconductor. The suggested mechanism is a strong interaction between neutron and proton Cooper pairs, which arises from an assumed U(2) symmetry of the effective potential, which is supposed to originate in isospin symmetry of the underlying nuclear interactions. To test this claim, we perform an explicit mean-field calculation of the effective potential of the Cooper pairs in a model with a simple four-point pairing interaction. In the neutron star context, matter is very neutron rich with less than 10% protons, so there is no neutron-proton pairing. We find that under these conditions our model shows no interaction between proton Cooper pairs and neutron Cooper pairs at the mean-field level. We estimate the leading contribution beyond mean field and find that it is is small and attractive at weak coupling.Comment: 7 pages, 2 figure

Modulated structure in the martensite phase of Ni1.8Pt0.2MnGa: a neutron diffraction study

7M orthorhombic modulated structure in the martensite phase of Ni1.8Pt0.2MnGa is reported by powder neutron diffraction study, which indicates that it is likely to exhibit magnetic field induced strain. The change in the unit cell volume is less than 0.5% between the austenite and martensite phases, as expected for a volume conserving martensite transformation. The magnetic structure analysis shows that the magnetic moment in the martensite phase is higher compared to Ni2MnGa, which is in good agreement with magnetization measurement

Effects of Eye-phase in DNA unzipping

The onset of an "eye-phase" and its role during the DNA unzipping is studied when a force is applied to the interior of the chain. The directionality of the hydrogen bond introduced here shows oscillations in force-extension curve similar to a "saw-tooth" kind of oscillations seen in the protein unfolding experiments. The effects of intermediates (hairpins) and stacking energies on the melting profile have also been discussed.Comment: RevTeX v4, 9 pages with 7 eps figure

Identifying Implementation Bugs in Machine Learning based Image Classifiers using Metamorphic Testing

We have recently witnessed tremendous success of Machine Learning (ML) in practical applications. Computer vision, speech recognition and language translation have all seen a near human level performance. We expect, in the near future, most business applications will have some form of ML. However, testing such applications is extremely challenging and would be very expensive if we follow today's methodologies. In this work, we present an articulation of the challenges in testing ML based applications. We then present our solution approach, based on the concept of Metamorphic Testing, which aims to identify implementation bugs in ML based image classifiers. We have developed metamorphic relations for an application based on Support Vector Machine and a Deep Learning based application. Empirical validation showed that our approach was able to catch 71% of the implementation bugs in the ML applications.Comment: Published at 27th ACM SIGSOFT International Symposium on Software Testing and Analysis (ISSTA 2018

Force induced triple point for interacting polymers

We show the existence of a force induced triple point in an interacting polymer problem that allows two zero-force thermal phase transitions. The phase diagrams for three different models of mutually attracting but self avoiding polymers are presented. One of these models has an intermediate phase and it shows a triple point but not the others. A general phase diagram with multicritical points in an extended parameter space is also discussed.Comment: 4 pages, 8 figures, revtex

A note on the cylindrical collapse of counter-rotating dust

We find analytical solutions describing the collapse of an infinitely long cylindrical shell of counter-rotating dust. We show that--for the classes of solutions discussed herein--from regular initial data a curvature singularity inevitably develops, and no apparent horizons form, thus in accord with the spirit of the hoop conjecture.Comment: 8 pages, LaTeX, ijmpd macros (included), 1 eps figure; accepted for publication in Int. J. Mod. Phys.

Strangelet dwarfs

If the surface tension of quark matter is low enough, quark matter is not self bound. At sufficiently low pressure and temperature, it will take the form of a crystal of positively charged strangelets in a neutralizing background of electrons. In this case there will exist, in addition to the usual family of strange stars, a family of low-mass large-radius objects analogous to white dwarfs, which we call "strangelet dwarfs". Using a generic parametrization of the equation of state of quark matter, we calculate the mass-radius relationship of these objects.Comment: 10 pages, LaTeX, added discussion of CFL phase and strangelet pollution, version to appear in journal. arXiv admin note: text overlap with arXiv:0808.067