Randomised prospective comparative analysis of functional outcome of osteosynthesis of intra-articular distal humerus fracture using triceps reflecting and transolecrenon approach

Background: Intra articular fractures of distal humerus is one of the demanding injuries to manage due to its complex anatomy. Open reduction internal fixation is able to achieve painless, stable and mobile joint. This study is aimed at comparing functional outcome of patients treated with triceps reflecting and olecranon osteotomy approach.Methods: A hospital based randomized comparative study of 40 patients who diagnosed with distal humerus intraarticular fracture admitted in our hospital from April 2017 to March 2019. Triceps reflecting approach (group A) was used in 20 patients and olecranon osteotomy approach (group B) in 20 patients. Elbow range of movements and Mayo elbow performance score (MEPS) was used to compare outcome.Results: The mean elbow range of motion is 95.8±13.5 degree at 1 year follow up in group A and 94.5±9.3 degree in 1 year follow up at 1 year follow up in group B. The mean MEP score at end of 1 year in group A was 93.8±2.9 and in group B was 91.5±3.2 shows excellent results but there was no statistically significant difference between MEP scores of two groups. We observed 6 patients developed extension lag less than 10 degree in group A which was clinically insignificant to patients and 7 patients developed hardware prominence in group B.Conclusions: Triceps reflecting Bryan Morrey approach is equally effective as olecranon osteotomy approach in treatment of distal humerus intra articular fracture with less complication and operative time

Perspectives in Marine Aquatic Resources and Health Management

Aquatic resources are now regarded as major contributors to provisioning services that include health-food supply and pharmaceutical products. There are tremendous opportunities to advantageously make use of the rich biodiversity; and the provisioning, regulatory, cultural and supporting services of our seas to meet the emerging demands of humankind. Since biodiversity and ecosystem functioning is inextricably linked to human societies, we have to value the services of both, considering the growing costs of biodiversity loss and ecosystem degradation. A greener environment with enhanced ecosystem services will be beneficial to the ecological and human well-being

Variation in fish catches from the continental shelf between Quilon and Gulf of Mannar and its relation to oceanographic conditions during the southwest monsoon period

The present paper is based on the fishing results of FORV Sagar Sampada during July-August, 1987 along the southwest coast of India. The fish fauna of the Quilon Bank and Wadge Bank has a dominant nemipterid element and the Gulf of Mannar area has a dominant population of barracudas. Nemipterids constituted 88.2 and 64.4% of the total trawl catch from the Quilon Bank and Wadge Bank respectively

Observations on the growth of Epinephelus malabaricus (Bloch and Schneider) in the onshore recirculating sea water system

Studies on growth of groupers in indoor tanks with recirculating sea water systems are very few. The present study on the grow-out production of the Malabar grouper, Epinephelus malabaricus, was carried out in indoor FRP tanks of 5 ton capacity, with recirculating sea water systems, using indigenously made in situ biofilters. Pre-sanitized, wild caught fingerlings were stocked at the rate of 12 to 17 numbers, with the total biomass not exceeding 1200-1400g, in each tank. Fingerlings were fed with trash fish twice a day initially, at 10% of their body weight. No supplementary formulated feed was given throughout this study period. After overcoming the initial period of stress due to transportation, growth was observed to be quite fast. At the end of seven months the fishes attained a weight ranging between 750 and 800g. The growth obtained in the present system was comparable to those obtained in other systems

Histology and ultrastructure of male reproductive system of the Indian Spiny lobster Panulirus homarus (Decapoda: Palinuridae)

The spiny lobster Panulirus homarus, distributed along the Southeast and Southwest coasts of India, is an important commercial species having mariculture potential. Despite its importance, the structural and ultrastructure features of male gonads from this species have received scarce attention. Hence this study was aimed to describe the male reproductive tract of the species, using standard histological and electron microscopy techniques. Gonads from 94 specimens of P. homarus ranging in carapace length 37mm-92mm from vizhinjam (Southwest coast of India.) were obtained and processed for the study (Histology-70 numbers & ultrastructure-24 numbers). The male reproductive system consists of paired testis and vas deferens located in the cephalo-thoracic region. Macroscopically, the reproductive tract was observed in lobsters >35mm carapace length. In immature testis, spermatogonia were seen which measured 6.9-13.8µm in diameter and in the mature testis primary (5.4-5.9µm) and secondary spermatocytes (2.8-3µm) and spermatids (2.2-2.4µm) were present. Each vas deferens consists of proximal and distal portions. The spermatophoric mass begins formation in the proximal vas deferens. In the distal vas deferens the spermatophoric mass containing the spermatozoa are arranged in packets towards the periphery by the gelatinous matrix produced by the typhlosole. Ultrastructurally, the spermatogonia have lamina, nucleus and mitochondria like bodies, the primary spermatocytes have nucleus, dense chromatin and vacuolated cytoplasm and the spermatids have mitochondria, endoplasmic reticulum and centrioles. The endoplasmic reticulum and the nuclear envelope in the spermatids form the acrosome. The radial arms with microtubules are formed in association with the dense endoplasmic reticulum, near the nucleus. The sperm has a spherical structure with the nucleus, lamellar region, spikes and acrosome. This is the first comprehensive report of the structure of the male gametes and spermatogenesis in P. homarus from Indian waters

Empirical linkages between ICT, tourism, and trade towards sustainable environment: evidence from BRICS countries

There is a growing utilisation of information and communication technologies (ICT) in the recent digital era. Trade and tourism have also attained attention as determinants of environmental sustainability. Therefore, this study investigates linkages between ICT, tourism, trade, economic growth, and environmental sustainability in BRICS economies. Advanced panel estimation entitled cross-sectionally augmented autoregressive distributed lags (CSARDL) was applied from 1990 to 2019. Findings suggest the adverse effect of tourism, trade, and growth factors on environmental sustainability, whereas ICT helps promote a sustainable environment among the targeted economies. Likewise, the shortrun results prove that economic growth and tourism are prone to ecological health, while trade possesses an insignificant influence on ecological sustainability. These results suggest the integration of ICT in trade and tourism sectors to mitigate their negative ecological consequences

DNA repair deficiency biomarkers and the 70-gene ultra-high risk signature as predictors of veliparib/carboplatin response in the I-SPY 2 breast cancer trial.

Veliparib combined with carboplatin (VC) was an experimental regimen evaluated in the biomarker-rich neoadjuvant I-SPY 2 trial for breast cancer. VC showed improved efficacy in the triple negative signature. However, not all triple negative patients achieved pathologic complete response and some HR+HER2- patients responded. Pre-specified analysis of five DNA repair deficiency biomarkers (BRCA1/2 germline mutation; PARPi-7, BRCA1ness, and CIN70 expression signatures; and PARP1 protein) was performed on 116 HER2- patients (VC: 72 and concurrent controls: 44). We also evaluated the 70-gene ultra-high risk signature (MP1/2), one of the biomarkers used to define subtype in the trial. We used logistic modeling to assess biomarker performance. Successful biomarkers were combined using a simple voting scheme to refine the 'predicted sensitive' group and Bayesian modeling used to estimate the pathologic complete response rates. BRCA1/2 germline mutation status associated with VC response, but its low prevalence precluded further evaluation. PARPi-7, BRCA1ness, and MP1/2 specifically associated with response in the VC arm but not the control arm. Neither CIN70 nor PARP1 protein specifically predicted VC response. When we combined the PARPi-7 and MP1/2 classifications, the 42% of triple negative patients who were PARPi7-high and MP2 had an estimated pCR rate of 75% in the VC arm. Only 11% of HR+/HER2- patients were PARPi7-high and MP2; but these patients were also more responsive to VC with estimated pathologic complete response rates of 41%. PARPi-7, BRCA1ness and MP1/2 signatures may help refine predictions of VC response, thereby improving patient care