55 research outputs found

    An efficient synthesis and antimicrobial activity of 3-benzylidene-1-phenylquinoline-2,4(1<em>H</em>,3<em>H</em>)-diones

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    341-347Cyanuric chloride has been reported for the first time for the synthesis of N-phenylhydroxyquinolone in TCM as solvent Further, it is condensed with various aromatic aldehydes in water with triethylamine as base The yields obtained are in the range of 82-97% under the microwave method All the synthesized compounds (Q1-Q10) belong to a new series and have been evaluated for their antibacterial and antifungal activity Synthesised series of quinolones, compounds Q2, Q3, Q5, Q8 and Q9 show activity against E coli, P aeruginosa, S aureus and B subtilis All synthesised compounds are found to be more potent than the standard drugs Ciprofloxacin and Miconazole when tested against the fungal strains C albicans and A niger
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