An efficient synthesis and antimicrobial activity of 3-benzylidene-1-phenylquinoline-2,4(1<em>H</em>,3<em>H</em>)-diones

341-347Cyanuric chloride has been reported for the first time for the synthesis of N-phenylhydroxyquinolone in TCM as solvent Further, it is condensed with various aromatic aldehydes in water with triethylamine as base The yields obtained are in the range of 82-97% under the microwave method All the synthesized compounds (Q1-Q10) belong to a new series and have been evaluated for their antibacterial and antifungal activity Synthesised series of quinolones, compounds Q2, Q3, Q5, Q8 and Q9 show activity against E coli, P aeruginosa, S aureus and B subtilis All synthesised compounds are found to be more potent than the standard drugs Ciprofloxacin and Miconazole when tested against the fungal strains C albicans and A niger

Determination of Exemestane in bulk and pharmaceutical dosage form by HPTLC

AbstractAn HPTLC method for analysis of Exemestane in bulk and pharmaceutical formulation has been established and validated. The analyte was separated on aluminium plates precoated with silica gel 60 F254. The mobile phase was chloroform:methanol 9.2:0.8 (v/v). Quantification was done by densitometric scanning at 247nm. Response was a linear function of Exemestane concentration in the range of 100–500μgmL−1. The limit of detection and quantification for Exemestane were 5.8 and 17.58μgmL−1, respectively. Average recovery of Exemestane was 100.1, which shows that the method was free from interference from excipients present in the formulation. The established method enabled accurate, precise, and rapid analysis of Exemestane in bulk as well as pharmaceutical formulation