44 research outputs found

    Authors' Reply to "Is Hib Vaccine of Economic Value in South Korea?"

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    Reversible photoluminescence switch: A stair-step Cu4I4 coordination polymer based on a dithioether ligand

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    AbstractA two-dimensional network stair-step Cu4I4 coordination polymer (1) based on 1,4-bis((methylthio)propanoyl)piperazine was prepared. No emission was observed from 1 (off state), while a heated sample (2) of 1 emitted a strong green light (on state). Conversion between 1 and 2 was reversible upon removal of acetonitrile or exposure of 2 to acetonitrile

    A CPW-Fed Rectangular Ring Monopole Antenna for WLAN Applications

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    We present a simple coplanar waveguide- (CPW-) fed rectangular ring monopole antenna designed for dual-band wireless local area network (WLAN) applications. The antenna is based on a simple structure composed of a CPW feed line and a rectangular ring. Dual-band WLAN operation can be achieved by controlling the distance between the rectangular ring and the ground plane of the CPW feed line, as well as the horizontal vertical lengths of the rectangular ring. Simulated and measured data show that the antenna has a compact size of 21.4×59.4 mm2, an impedance bandwidths of 2.21–2.70 GHz and 5.04–6.03 GHz, and a reflection coefficient of less than −10 dB. The antenna also exhibits an almost omnidirectional radiation pattern. This simple compact antenna with favorable frequency characteristics therefore is attractive for applications in dual-band WLAN

    Cost-Benefit Analysis of Haemophilus Influenzae Type B Immunization in Korea

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    An economic evaluation of Haemophilus influenzae type b (Hib) immunization was conducted to examine whether Hib immunization should be included in the Korea's national immunization program. The costs and benefits included direct and indirect values and an estimation of the economic efficiency. We determined that a universal Hib immunization program in Korea would prevent 17 deaths and 280 invasive Hib cases. When we assumed the one Hib immunization cost as 26,000 won, the national Hib immunization would cost 34.6 billion won. Costs for various Hib diseases were estimated at 26.8 billion won (11.8 billion won from direct costs and 14.9 billion won from indirect costs). A benefit-cost ratio of 0.77 showed that the economic efficiency of the integration of Hib immunization in Korea is low because of the low incidence rate of Hib disease and high price of vaccine. However, if the Hib immunization cost decrease to less than 20,000 won, a benefit-cost ratio increase to 1.0 and above, integrating Hib immunization into the national immunization program with economic efficiency can be considered

    First record of Cordilura shatalkini Ozerov, 1997 and Cordilura nubecula Sasakawa, 1986 (Diptera: Scathophagidae) from Korea

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    The species of the genus Cordilura Fallén are not well studied in Korea with only one known species. In this study, Cordilura shatalkini and Cordilura nubecula are reported for the first time in Korea with a new key to the species of Cordilura from Korea

    A splice variant acquiring an extra transcript leader region decreases the translation of glutamine synthetase gene.

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    The expression of glutamine synthetase (GS), catalysing the ATP-dependent conversion of glutamate and ammonia into glutamine, is transcriptionally and post-transcriptionally regulated. The genomic structure of dog GS shown in the present study is basically similar to that of other mammals in that it is composed of seven exons and six introns. Using 5'-cRACE (where cRACE stands for circular rapid amplification of cDNA ends) and reverse transcriptase-PCR, we identified an additional exon (120 bp) in the first intron, designated in the present study as exon 1'. By means of alternative splicing, the GS gene produces an altered form of GS transcript with 5'-untranslated region (UTR) containing the exon 1'. This alternative transcript is abundantly expressed in brain, whereas it is found at lower levels in other tissues. In the human and mouse GS genes, extra exons are also found at the corresponding site of the intron 1 but with different sizes. An exon-trapping experiment for the GS gene in COS-7, Madin-Darby canine kidney and SK-N-SH cells revealed that the pattern of alternative splicing is variable in different cell types. The propensity of forming a secondary structure is predicted to be considerably higher in the presence of extra 5'-UTR, suggesting the possibility of a translational effect. To test this, we performed a reporter assay for fusions with different 5'-UTRs, demonstrating that the long form with extra 5'-UTR was translated 20- and 10-fold less than the short one in SK-N-SH and Neuro-2A cells respectively. Similarly, translations of human and mouse transcripts with extra 5'-UTRs were less efficient, showing 6-8-fold reductions in SK-N-SH cells. Furthermore, when we mutated an ATG sequence contained in the exon 1', the suppression of translation was partially relieved, suggesting that the negative regulation by an extra 5'-UTR is, to some extent, due to an abortive translation from the upstream ATG

    Data Hiding in Windows Executable Files

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    A common technique for hiding information in executable files is the embedding a limited amount of information in program binaries. The hiding technique is commonly achieved by using special software tools as e.g. the tools presented by Hydan and Stilo in (Rakan, 2004, Bertrand, 2005). These tools can be used to commit crimes as e.g. industrial spy activities or other forms of illegal data access. In this paper, we propose new methods for hiding information in Portable Executable (PE) files. PE is a file format for executables used in the 32-bit and 64-bit versions of the Windows operating system. In addition, we discuss the analysis techniques which can be applied to detect and recover data hidden using each of these methods. The existing techniques for hiding information in an executable file determine the total number of bytes to be hidden on the foundation of the size of the executable code. Our novel methods proposed here do not limit the amount of hidden code

    Development of a Multi-Array Pressure Sensor Module for Radial Artery Pulse Wave Measurement

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    This study proposes a new structure for a pressure sensor module that can reduce errors caused by measurement position and direction in noninvasive radial artery pulse wave measurement, which is used for physiological monitoring. We have proposed a structure for a multi-array pressure sensor with a hexagonal arrangement and polydimethylsiloxane that easily fits to the structure of the radial artery, and evaluated the characteristics and pulse wave measurement of the developed sensor by finite element method simulation, a push–pull gauge test, and an actual pulse wave measurement experiment. The developed sensor has a measuring area of 17.6 × 17.6 mm2 and a modular structure with the analog front end embedded on the printed circuit board. The finite element method simulation shows that the developed sensor responds linearly to external pressure. According to the push–pull gauge test results for each channel, there were differences between the channels caused by the unit sensor characteristics and fabrication process. However, the correction formula can minimize the differences and ensure the linearity, and root-mean-squared error is 0.267 kPa in calibrated output. Although additional experiments and considerations on inter-individual differences are required, the results suggested that the proposed multiarray sensor could be used as a radial arterial pulse wave sensor

    Power Reduction Technique in Coefficient Multiplications Through Multiplier Characterization

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    This paper presents a multiplier power reduction technique for low-power DSP applications through utilization of coefficient optimization. The optimization is implementation dependent in that the multipliers are assumed to be designed in either ASIC or full-custom architectures for general purpose multiplication. The paper first describes a model characterizing the power consumption of the multiplier. Then the coefficient optimized made based on this model. This methodology is applicable to multiplications requiring a large set of coefficients and random data sets.We can accurately estimate the actual power dissipation of the multipliers using the characterization technique. The coefficient optimization based on the power model can save as much as 34.02%
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