Thiol peroxidase-like activity of some intramolecularly coordinated diorganyl diselenides

Several new diaryl diselenides having intramolecular coordinating groups have been synthesized by ortho-lithiation/Na2Se2 routes in good yield. Bis[2-(N-phenylferrocenecarboxamide)] diselenide (10), bis[2-(N-tert-butylferrocenecarboxamide)] diselenide (11), (S)(S)-bis[2(-N-phenethylferrocene-carboxamide)] diselenide (12) were synthesized by the ortho-lithiation route. Bis[2-(N,N-dimethyl-aminomethylnaphthyl)] diselenide (13) was synthesized by lithium/bromide exchange reaction whereas bis(2,4-dinitrophenyl) diselenide (14) was prepared by the reaction of disodium diselenide with 2,4-dinitro-1-chlorobenzene. Thiol peroxidase-like activities of the diorganodiselenides have been evaluated by using H2O2 as substrate and PhSH as cosubstrate. Diselenides (13) and (14) with dimethylami-nomethyl- or nitro-donor groups in close proximity to selenium, show much better thiol peroxidase-like activities compared to diselenides 10-12 with amide donor groups. Cyclic voltammetry study of diselenides 10-12 derived from redox-active ferrocenamide has been carried out

Formulation and Comparative in-vitro Evaluation of Mucoadhesive Buccal Tablets of Furosemide

This study was conducted to develop mucoadhesive buccal tablet of Frusemide. A Mucoadhesive buccal tablet of Frusemide were prepared by using wet granulation method using dfferent polymer such as HPMC k 100, Carbopol-940 in different ratio. Tablets were analysed by measuring different parameters thickness, hardness weight uniformity, drug content uniformity, LOD, sweeling index, invitro dissolution study and solubility. The tablets were evaluated for in vitro release in pH 6.8-phosphate buffer for 12 hr in standard dissolution apparatus. Mucoadhesion strength was increased with increase in the concentration of carbopol. In order to determine the mode of release, the data was subjected to Zero order, first order, Higuchi and Peppas diffusion model

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Palladium-Catalyzed Removable 8‑Aminoquinoline Assisted Chemo- and Regioselective Oxidative <i>sp</i>²‑C–H/<i>sp</i>³‑C–H Cross-Coupling of Ferrocene with Toluene Derivatives

The coupling of the C­(<i>sp</i>²)–H bond of ferrocene with toluene avoiding <i>in situ</i> functionalization of both coupling partners has been achieved using palladium and iron dual catalysis. This cross oxidative coupling features regioselectivity to primary and secondary C­(<i>sp</i>³)–H bonds and chemoselectivity toward the −C­(<i>sp</i>³)–H over C–I bond of toluene with gram-scale production. It seems Fe­(II) catalyst not only stabilizes the generated benzyl radical but also tames its oxidizing behavior, and consequently transfers it to the palladacycle for C–C coupling

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Not AvailableThe of aim of this study was to evaluate the potentiality of the native isolate of Trichoderma harzianum from IARI farm for the management of post-flowering stalk rot of maize and improvement of plant health.The treatment was tried as a seed treatment with the potent commercial formulation Kalisena SD (Aspergillus niger), neem kernel powder and effective fungicides (Thiram, Carbendazim, Captan) for comparison of its efficacy. The minimum disease was recorded in plots treated with native isolate both due to Fusarium moniliforme and Macrophomina phaseolina. The fungicides Carbendazim and Thiram ranked second in controlling the disease due to F. moniliforme and M. phaseolina, respectively. Plant health with respect to vigour and plant stand were found to be better than those of all the other treatments. It is concluded that the native isolate of T. harzianum may be used for maintaining good plant health and managing post-flowering stalk rot of maize.Not Availabl

Selective Oxidative Decarbonylative Cleavage of Unstrained C(<i>sp</i>³)–C(<i>sp</i>²) Bond: Synthesis of Substituted Benzoxazinones

A transition metal (TM)-free practical synthesis of biologically relevant benzoxazinones has been established via a selective oxidative decarbonylative cleavage of an unstrained C­(<i>sp</i>³)–C­(<i>sp</i>²) bond employing iodine, sodium bicarbonate, and ^<i>t</i>butyl hydroperoxide in DMSO at 95 °C. Control experiments and Density Functional Theory (DFT) calculations suggest that the reaction involves a [1,5]H shift and extrusion of CO gas as the key steps. The extrusion of CO has also been established using PMA–PdCl₂

Cinchona-Alkaloids Based Isoselenazolones: Synthesis and Their Catalytic Reactivity in Asymmetric Bromolactonization of Alkenoic Acid

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Synthesis, characterization and crystal structure of 2-((4-bromophenyl) carbamoyl) phenylselenenyl bromide derived from oxidative addition of bromine to 2-phenyl-1,2-benzoisoselenazol-3-(2H)-one

1078-1085Oxidative addition of elemental bromine to 2-phenyl-1, 2-benzoisoselenazol-3-(2H)-one has been studied. Reaction of bromine with selenazolone gives the corresponding 2-phenyl-1,2-benzoisoselenazol-3-(2H)-one(IV) dibromide, which slowly rearranges to 2-((4-bromophenyl)carbamoyl)phenylselenenyl bromide when kept for crystallization for a longer period of time (24 days). Molecular conformation of the selenenyl bromide is found to be stabilized due to the presence of an intramolecular Se…O interaction along with the weak C-H…O and C-H…Br hydrogen bonds. The nature of the intramolecular Se…O interaction in selenenyl bromide has been studied by multi-nuclear (1H, 13C, and 77Se) NMR spectroscopy

Sensitive and regenerable organochalcogen probes for the colorimetric detection of thiols

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Reagent Free Light-Driven Site Selective Carbon-Carbon Coupling of Aliphatic Alcohols with 1,4-Naphthoquinones

Here, first-ever an -selective Csp3‒H bond functionalization of primary aliphatic alcohols with 1,4-naphthoquinones yield-ed Csp2‒Csp2 coupled products is reported, driven by blue-LEDs light in photo-catalyst, metal, base, reagent free conditions. In this transformation, cleavage of three C-H bonds (two sp3-C-H, one sp2-C-H, and one O-H) and four new bonds formed, leading to fluorescent 2-acylated-1,4-naphthohydroquinones