LIME -- a gas TPC prototype for directional Dark Matter search for the CYGNO experiment

The CYGNO experiment aims at the development of a large gaseous TPC with GEM-based amplification and an optical readout by means of PMTs and scientific CMOS cameras for 3D tracking down to O(keV) energies, for the directional detection of rare events such as low mass Dark Matter and solar neutrino interactions. The largest prototype built so far towards the realisation of the CYGNO experiment demonstrator is the 50 L active volume LIME, with 4 PMTs and a single sCMOS imaging a 33$\times$33 cm\textsuperscript{2} area for 50 cm drift, that has been installed in underground Laboratori Nazionali del Gran Sasso in February 2022. We will illustrate LIME performances as evaluated overground in Laboratori Nazionali di Frascati by means of radioactive X-ray sources, and in particular the detector stability, energy response and energy resolution. We will discuss the MC simulation developed to reproduce the detector response and show the comparison with actual data. We will furthermore examine the background simulation worked out for LIME underground data taking and illustrate the foreseen expected measurement and results in terms of natural and materials intrinsic radioactivity characterisation and measurement of the LNGS underground natural neutron flux. The results that will be obtained by underground LIME installation will be paramount in the optimisation of the CYGNO demonstrator, since this is foreseen to be composed by multiple modules with the same LIME dimensions and characteristics

The CYGNO Experiment

The search for a novel technology able to detect and reconstruct nuclear and electron recoil events with the energy of a few keV has become more and more important now that large regions of high-mass dark matter (DM) candidates have been excluded. Moreover, a detector sensitive to incoming particle direction will be crucial in the case of DM discovery to open the possibility of studying its properties. Gaseous time projection chambers (TPC) with optical readout are very promising detectors combining the detailed event information provided by the TPC technique with the high sensitivity and granularity of latest-generation scientific light sensors. The CYGNO experiment (a CYGNus module with Optical readout) aims to exploit the optical readout approach of multiple-GEM structures in large volume TPCs for the study of rare events as interactions of low-mass DM or solar neutrinos. The combined use of high-granularity sCMOS cameras and fast light sensors allows the reconstruction of the 3D direction of the tracks, offering good energy resolution and very high sensitivity in the few keV energy range, together with a very good particle identification useful for distinguishing nuclear recoils from electronic recoils. This experiment is part of the CYGNUS proto-collaboration, which aims at constructing a network of underground observatories for directional DM search. A one cubic meter demonstrator is expected to be built in 2022/23 aiming at a larger scale apparatus (30 m$^3$--100 m$^3$) at a later stage

Right-left prevalence effect with horizontal and vertical effectors

We investigated the right-left prevalence effect in spatial compatibility tasks by assessing subjects' performance on a two-dimensional task in which both the horizontal and vertical spatial dimensions were task relevant. Two experiments were performed, in which stimulus-response mappings were one-dimensional (Experiment 1) and two-dimensional (Experiment 2). The subjects responded by using either horizontal or vertical effectors to stimuli appearing in four possible locations. With the one-dimensional mapping, the spatial compatibility effect was present only in the dimension relevant to the mapping. With the two-dimensional mapping, the horizontal compatibility effect was always present, whereas the vertical compatibility effect was present only when vertical effectors were used. This pattern of results indicates that horizontal coding takes place with either horizontal or vertical effectors, whereas vertical coding takes place only when vertical effectors are used

Lab-on-Chip Prototype for the Detection of Coronary Artery Disease Biomarkers

We report an easy-to-use Lab-on-Chip (LoC) device able to detect soluble, circulating biomarkers in plasma that are relevant to Coronary Artery Disease (CAD). The LoC prototype is developed within the SMARTool European project and is intended to be used for Point-of-Care (PoC) testing of patients with CAD, facilitating more rapid and efficient monitoring and treatment decisions. A LoC prototype is presented, enabling chemiluminescent assays to be performed on chip targeting biomarkers relevant to CAD. In parallel, a robust technology for electrostatically actuated, capillary burst valve for PoC applications, integrated in potentially disposable, thermoplastic devices is reported. The devices were fabricated using easily scalable fabrication techniques and can be used to perform multistep assays on single-use microfluidic devices

Right hepatic vein bullet embolism: A case report

Penetrating trauma is usually divided into stab and gunshot wounds (GSW). When considering GSW, the initial assessment involves the identification of all the wounds, to understand the projectile's trajectory as well as to determine which anatomic structures might have been damaged [1]. Rarely, the projectile might not leave the victim's body and embolize to a different region through large blood vessels. Known as Missile Embolism (ME), this uncommon complication can compromise multiple body segments, resulting in severe injuries, whether it occurs through an artery or a vein, such as pulmonary embolism, cardiac-valve incompetence, limb-threatening ischemia, coronary infarct, and stroke [2,3]. This is a case report of an 18-year-old male patient who suffered a gunshot wound and was submitted to an exploratory laparotomy which identified a laceration of the inferior vena cava. Further exams concluded that the bullet was embolized to the right hepatic vein. ME treatment will depend mostly on the bullet's placement; if located in the left circulation or arterial vessels, retrieval is the preferred treatment. It can be executed through surgical exploration or endovascular procedure [3,4,8] Venous ME has several treatment options, including conservative management if the patient remains asymptomatic [3–7]. Cases of paradoxical embolization might be managed as arterial ME [3,4]

Metodologie di indagine per la valutazione della pericolosità sismica locale dell'Area Archeologica Centrale di Roma

In questa memoria sono descritti i metodi di indagine utilizzati per realizzare il modello di sottosuolo dell'area Archeologica Centrale di Roma, al fine di valutarne la pericolosità sismica locale. Lo studio è stato realizzato per conto del Commissario delegato per le Aree Archeologiche di Roma e Ostia Antica e in stretta collaborazione con il Dipartimento della Protezione Civile. Diverse unità di ricerca, con competenze nei campi della geologia, della geotecnica, della geofisica e dell’archeologia, nel corso del 2010 sono state impegnate in acquisizioni sul campo e indagini di laboratorio i cui risultati hanno consentito: 1) di rivalutare l'assetto stratigrafico, idrogeologico e geotecnico dell'area in studio e realizzare una cartografia geologica e idrogeologica aggiornata in scala 1:2000, corredata da sette profili geologici; 2) di definire un modello di sottosuolo finalizzato alla valutazione della risposta sismica locale, attraverso a) una mappatura della morfologia sepolta sotto la coltre antropica, b) l'individuazione del basamento sismico, c) la caratterizzazione dei terreni e delle rocce tenere in campo ciclico. Il modello di sottosuolo così definito è propedeutico alle analisi numeriche 2D e, quindi, alla realizzazione della carta di microzonazione sismica di livello 3, attualmente in fase di ultimazione

Directional Dark Matter Searches with CYGNO

The CYGNO project aims at developing a high resolution Time Projection Chamber with optical readout for directional dark matter searches and solar neutrino spectroscopy. Peculiar CYGNO’s features are the 3D tracking capability provided by the combination of photomultipliers and scientific CMOS camera signals, combined with a helium-fluorine-based gas mixture at atmospheric pressure amplified by gas electron multipliers structures. In this paper, the performances achieved with CYGNO prototypes and the prospects for the upcoming underground installation at Laboratori Nazionali del Gran Sasso of a 50-L detector in fall 2021 will be discussed, together with the plans for a 1-m3 experiment. The synergy with the ERC consolidator, grant project INITIUM, aimed at realising negative ion drift operation within the CYGNO 3D optical approach, will be further illustrated

LIME. A gas TPC prototype for directional Dark Matter search for the CYGNO experiment

The CYGNO experiment aims at the development of a large gaseous TPC with GEM-based amplification and an optical readout by means of PMTs and scientific CMOS cameras for 3D tracking down to O(keV) energies, for the directional detection of rare events such as low mass Dark Matter and solar neutrino interactions. The largest prototype built so far towards the realisation of the CYGNO experiment demonstrator is the 50 L active volume LIME, with 4 PMTs and a single sCMOS imaging a 33×33 cm2 area for 50 cm drift, that has been installed in underground Laboratori Nazionali del Gran Sasso in February 2022. We will illustrate LIME performances as evaluated overground in Laboratori Nazionali di Frascati by means of radioactive X-ray sources, and in particular the detector stability, energy response and energy resolution. We will discuss the MC simulation developed to reproduce the detector response and show the comparison with actual data. We will furthermore examine the background simulation worked out for LIME underground data taking and illustrate the foreseen expected measurement and results in terms of natural and materials intrinsic radioactivity characterisation and measurement of the LNGS underground natural neutron flux. The results that will be obtained by underground LIME installation will be paramount in the optimisation of the CYGNO demonstrator, since this is foreseen to be composed by multiple modules with the same LIME dimensions and characteristic

The CYGNO experiment, a directional detector for direct Dark Matter searches

The CYGNO project aims at the development of a high precision optical readout gaseous Tima Projection Chamber (TPC) for directional dark matter (DM) searches, to be hosted at Laboratori Nazionali del Gran Sasso (LNGS). CYGNO employs a He:CF gas mixture at atmospheric pressure with a Gas Electron Multiplier (GEM) based amplification structure coupled to an optical readout comprised of sCMOS cameras and photomultiplier tubes (PMTs). This experimental setup allows to achieve 3D tracking and background rejection down to O(1) keV energy, to boost sensitivity to low WIMP masses. The characteristics of the optical readout approach in terms of the light yield will be illustrated along with the particle identification properties. The project timeline foresees, in the next 2–3 years, the realisation and installation of a 0.4 m3 TPC in the underground laboratories at LNGS to act as a demonstrator. Finally, the studies of the expected DM sensitivities of the CYGNO demonstrator will be presented