241 research outputs found

    A Rosetta Stone Relating Conventions In Photo-Meson Partial Wave Analyses

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    A new generation of complete experiments in pseudoscalar meson photo-production is being pursued at several laboratories. While new data are emerging, there is some confusion regarding definitions of asymmetries and the conventions used in partial wave analyses (PWA). We present expressions for constructing asymmetries as coordinate-system independent ratios of cross sections, along with the names used for these ratios by different PWA groups. (This update reflects a recent change in the definition of an asymmetry as used by one group.)Comment: v2: This update reflects a recent change in the definition of an asymmetry as used by one PWA group -see Table 1. v1: 4 pages. Contribution to the proceedings of the 8th International Workshop on the Physics of Excited Nucleons (NSTAR2011), Newport News, VA, USA, May 17-20, 201

    Excess length of hospital stay due to healthcare acquired infections. Methodologies evaluation

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    BACKGROUND: Healthcare acquired infections (HAI) cause an increase of burden and in particular excess length of hospital stay (LOS) accounts for approximately up to 90% of total costs. Therefore accurate estimation of extra hospital stay due to healthcare acquired infections is very important. METHODS: The authors carried out a review comparing the principal methods internationally used for estimating the excess LOS attributable to healthcare acquired infections. RESULTS: The methods described and analysed are: 1) Implicit physician assessment; 2) appropriateness evaluation protocol; 3) unmatched case-control; 4) matched case-control; 5) regression analysis; 6) multistate model. The various methodologies are described underlining advantages and limits which researchers need to know before starting any economic analysis. CONCLUSIONS: Overall, studies taking into account the time-dependent nature of HAI show to give more precise and reliable results

    Role of protein kinase C-delta in the regulation of collagen gene expression in scleroderma fibroblasts

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    Working with cultured dermal fibroblasts derived from control individuals and patients with systemic sclerosis (SSc), we have examined the effects of protein kinase C-delta (PKC-delta) on type I collagen biosynthesis and steady-state levels of COL1A1 and COL3A1 mRNAs. Rottlerin, a specific inhibitor of PKC-delta, exerted a powerful, dose-dependent inhibition of type I and type III collagen gene expression in normal and SSc cells. Optimal rottlerin concentrations caused a 70-90% inhibition of type I collagen production, a \u3e80% reduction in COL1A1 mRNA, and a \u3e70% reduction in COL3A1 mRNA in both cell types. In vitro nuclear transcription assays and transient transfections with COL1A1 promoter deletion constructs demonstrated that rottlerin profoundly reduced COL1A1 transcription and that this effect required a 129-bp promoter region encompassing nucleotides -804 to -675. This COL1A1 segment imparted rottlerin sensitivity to a heterologous promoter. Cotransfections of COL1A1 promoter constructs with a dominant-negative PKC-delta expression plasmid showed that suppression of this kinase silenced COL1A1 promoter activity. The results indicate that PKC-delta participates in the upregulation of collagen gene transcription in SSc and suggest that treatment with PKC-delta inhibitors could suppress fibrosis in this disease

    On the Gerasimov-Drell-Hearn sum rule for the deuteron

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    The Gerasimov-Drell-Hearn sum rule is evaluated for the deuteron by explicit integration up to 550 MeV including contributions from the photodisintegration channel and from coherent and incoherent single pion production as well. The photodisintegration channel converges fast enough in this energy range and gives a large negative contribution, essentially from the 1S0^1S_0 resonant state near threshold. Its absolute value is about the same size as the sum of proton and neutron GDH values. It is only partially cancelled by the single pion production contribution. But the incoherent channel has not reached convergence at 550 MeV.Comment: 6 pages latex including 3 postscript figures, talk at the 15th Int. Conf. on Few-Body Problems in Physics, Groningen, Netherlands, 22-26 July 1997. To be published in Nucl. Phys.
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