Training Programmes and Success of Agri Clinics and Agri Business Centres (Acabcs) In Karnataka – An Evaluation

Agriculture Sector is contributing 16.5%to the GDP of the country and has enclosed more than 50% workforce are still engaged in agriculture and allied activities. (Economic survey 2019-20)Though higher workforce is involved, they are not self-reliable to earn their livelihood and it is indispensable to rethink the shift of agricultural sector. In this scenario Agri entrepreneurship or farm entrepreneurship apparently benefits the small-scale farmers to be self- reliable and independent. The National Institute for Management of Agricultural Extension (MANAGE) has classified 32 activities of agribusiness all over India (as on 5th February 2021) covering horticulture, floriculture, sericulture, dairy farming, poultry, agri clinics and agribusiness centres. Agri Clinics and Agri Business Centres (ACABCS) in the post globalization era have emerged as an important commercial activity in agriculture and Agribusiness undertakings formed by trained agriculturists. Such business may include sale of inputs, maintenance and custom hiring of farm equipment with other facilities in agriculture and allied areas as well as market linkages for revenue generation, post-harvest administration and entrepreneurial progress. Nodal Training institutes are contributing significantly for the development and growth of ACABCs. With this background, the study is undertaken at with an objective of examining the relationship of training programmes and the success of ACABCs in Karnataka. Sixty (29 Trained and 31 untrained) sample Agripreneurs drawn from Bengaluru urban and rural districtswere contacted with a structured questionnaire to understand their business growth and success level with the help of various parameters. Hypothesis testing was done with the help of Chi square test. For analysis simple percentage technique was applied. It has also come out with few findings and suggestions

Location of Pathogenic Bacteria during Persistent Infections: Insights from an Analysis Using Game Theory

Bacterial persistent infections are responsible for a significant amount of the human morbidity and mortality. Unlike acute bacterial infections, it is very difficult to treat persistent bacterial infections (e.g. tuberculosis). Knowledge about the location of pathogenic bacteria during persistent infection will help to treat such conditions by designing novel drugs which can reach such locations. In this study, events of bacterial persistent infections were analyzed using game theory. A game was defined where the pathogen and the host are the two players with a conflict of interest. Criteria for the establishment of Nash equilibrium were calculated for this game. This theoretical model, which is very simple and heuristic, predicts that during persistent infections pathogenic bacteria stay in both intracellular and extracellular compartments of the host. The result of this study implies that a bacterium should be able to survive in both intracellular and extracellular compartments of the host in order to cause persistent infections. This explains why persistent infections are more often caused by intracellular pathogens like Mycobacterium and Salmonella. Moreover, this prediction is in consistence with the results of previous experimental studies

Differentially Evolved Genes of Salmonella Pathogenicity Islands: Insights into the Mechanism of Host Specificity in Salmonella

BACKGROUND: The species Salmonella enterica (S. enterica) includes many serovars that cause disease in avian and mammalian hosts. These serovars differ greatly in their host range and their degree of host adaptation. The host specificity of S. enterica serovars appears to be a complex phenomenon governed by multiple factors acting at different stages of the infection process, which makes identification of the cause/s of host specificity solely by experimental methods difficult. METHODOLOGY/PRINCIPAL FINDINGS: In this study, we have employed a molecular evolution and phylogenetics based approach to identify genes that might play important roles in conferring host specificity to different serovars of S. enterica. These genes are 'differentially evolved' in different S. enterica serovars. This list of 'differentially evolved' genes includes genes that encode translocon proteins (SipD, SseC and SseD) of both Salmonella pathogenicity islands 1 and 2 encoded type three secretion systems, sptP, which encodes an effector protein that inhibits the mitogen-activated protein kinase pathway of the host cell, and genes which encode effector proteins (SseF and SifA) that are important in placing the Salmonella-containing vacuole in a juxtanuclear position. CONCLUSIONS/SIGNIFICANCE: Analysis of known functions of these 'differentially evolved genes' indicates that the products of these genes directly interact with the host cell and manipulate its functions and thereby confer host specificity, at least in part, to different serovars of S. enterica that are considered in this study

Molecular assembly of amino acid interlinked, topologically symmetric, π-complementary donor–acceptor–donor triads

Amino acid interlinked pyrene and naphthalenediimide (NDI) based novel donor–acceptor–donor (D-A-D) triads are designed to exploit their topological symmetry and complementary π-character for facile charge-transfer complexation. Consequently, free-floating high-aspect-ratio supercoiled nanofibres and hierarchical helical bundles of triads are realized by modulating the chemical functionality of interlinking amino acids

Studies on the Strength of Plastered Brick Masonry Prisms

Masonry buildings are the most common type of construction used for housing purpose both in urban and rural areas. The load bearing walls of masonry structures are usually designed to carry axial loads. However, they are often subjected to lateral loads due to wind and earthquake. The characteristics of brick masonry are influenced by the properties of bricks, mortar and brick-mortar interface. In this study, an attempt has been made to investigate the affect of plastering on compressive strength and flexural strength of brick masonry prisms. Experimental work has been carried out to assess the compressive strength and flexural strength of rendered and standard brick masonry using compression test, modified bond wrench test and two point loading test. Tests were carried out on the constituent materials used in the present experimental investigation. A total of 30 prisms were tested with different proportions of cement mortar 1:4, 1:6, cement soil mortar 1:4:4 and polyester coating in order to study the influence of plastering on strength of brick masonry. The major conclusions of this experimental study are plastering increases the measured compressive and flexural strength of rendered brick masonry prisms. Rendered prisms are found to be stiffer than that of the standard prisms.

Division of the Salmonella-Containing Vacuole and Depletion of Acidic Lysosomes in Salmonella-Infected Host Cells Are Novel Strategies of Salmonella enterica To Avoid Lysosomes▿

Salmonella has evolved several strategies to counteract intracellular microbicidal agents like reactive oxygen and nitrogen species. However, it is not yet clear how Salmonella escapes lysosomal degradation. Some studies have demonstrated that Salmonella can inhibit phagolysosomal fusion, whereas other reports have shown that the Salmonella-containing vacuole (SCV) fuses/interacts with lysosomes. Here, we have addressed this issue from a different perspective by investigating if the infected host cell has a sufficient quantity of lysosomes to target Salmonella. Our results suggest that SCVs divide along with Salmonella, resulting in a single bacterium per SCV. As a consequence, the SCV load per cell increases with the division of Salmonella inside the host cell. This demands more investment from the host cell to counteract Salmonella. Interestingly, we observed that Salmonella infection decreases the number of acidic lysosomes inside the host cell both in vitro and in vivo. These events potentially result in a condition in which an infected cell is left with insufficient acidic lysosomes to target the increasing number of SCVs, which favors the survival and proliferation of Salmonella inside the host cell

Security enhanced emergency situation detection system for ambient assisted living

Abstract Typical wearable devices use a dedicated mobile phone as relay node to transfer the collected sensor data to a server. However, such relay nodes can be faulty or inactive due to various reasons, leading to interruptions of the communication link. To mitigate this challenge, we propose a novel security-enhanced emergency situation detection system, where 3rd party unknown mobile relays are used instead of dedicated gateways as opposed to many existing solutions for IoT healthcare applications. The proposed underlying key agreement and authentication scheme ensures anonymity and untraceability for both sensors (wearable devices) and relay nodes, and relies on symmetric key-based operations to function under resource-constrained environments. We have also developed a prototype of the system using commercial off-the-shelf devices to verify the proposed method’s validity and evaluate the performance advantage over existing approaches. Bluetooth Low Energy (BLE) communication technology is used to connect sensor nodes (wearable devices) and mobile relays. After sending medical data to the cloud server, the relay node is responsible for emergency detection and alert generation

Cyclic regulation of sensory perception by a female hormone alters behavior

Females may display dramatically different behavior depending on their state of ovulation. This is thought to occur through sex-specific hormones acting on behavioral centers in the brain. Whether incoming sensory activity also differs across the ovulation cycle to alter behavior has not been investigated. Here, we show that female mouse vomeronasal sensory neurons (VSNs) are temporarily and specifically rendered "blind" to a subset of male-emitted pheromone ligands during diestrus yet fully detect and respond to the same ligands during estrus. VSN silencing occurs through the action of the female sex-steroid progesterone. Not all VSNs are targeted for silencing; those detecting cat ligands remain continuously active irrespective of the estrous state. We identify the signaling components that account for the capacity of progesterone to target specific subsets of male-pheromone responsive neurons for inactivation. These findings indicate that internal physiology can selectively and directly modulate sensory input to produce state-specific behavior. PAPERCLIP

Switching the Mode of Drug Release from a Reaction-Coupled Low-Molecular-Weight Gelator System by Altering Its Reaction Pathway

Low-molecular-weight hydrogels are attractive scaffolds for drug delivery applications because of their modular and facile preparation starting from inexpensive molecular components. The molecular design of the hydrogelator results in a commitment to a particular release strategy, where either noncovalent or covalent bonding of the drug molecule dictates its rate and mechanism. Herein, we demonstrate an alternative approach using a reaction-coupled gelator to tune drug release in a facile and user-defined manner by altering the reaction pathway of the low-molecular-weight gelator (LMWG) and drug components through an acylhydrazone-bond-forming reaction. We show that an off-the-shelf drug with a reactive handle, doxorubicin, can be covalently bound to the gelator through its ketone moiety when the addition of the aldehyde component is delayed from 0 to 24 h, or noncovalently bound with its addition at 0 h. We also examine the use of an l-histidine methyl ester catalyst to prepare the drug-loaded hydrogels under physiological conditions. Fitting of the drug release profiles with the Korsmeyer-Peppas model corroborates a switch in the mode of release consistent with the reaction pathway taken: increased covalent ligation drives a transition from a Fickian to a semi-Fickian mode in the second stage of release with a decreased rate. Sustained release of doxorubicin from the reaction-coupled hydrogel is further confirmed in an MTT toxicity assay with MCF-7 breast cancer cells. We demonstrate the modularity and ease of the reaction-coupled approach to prepare drug-loaded self-assembled hydrogels in situ with tunable mechanics and drug release profiles that may find eventual applications in macroscale drug delivery. ChemE/Advanced Soft Matte