Protective/restorative role of the adipose tissue-derived mesenchymal stem cells on the radioiodine-induced salivary gland damage in rats

To analyze protective/regenerative effects of adipose tissue-derived mesenchymal stem cells (ADMSC) on 131I-Radioiodine (RAI)-induced salivary gland damage in rats

Protective/Restorative Role of the Adipose Tissue-Derived Mesenchymal Stem Cells on the Radioiodine-Induced Salivary Gland Damage in Rats

Background. To analyze protective/regenerative effects of adipose tissue-derived mesenchymal stem cells (ADMSC) on I-131-Radioiodine (RAI)-induced salivary gland damage in rats. Materials and Methods. Study population consisted of controls (n: 6) and study groups (n: 54): RAI (Group 1), ADMSC (Group 2), amifostine (Group 3), RAI+ amifostine (Group 4), concomitant RAI+ ADMSC (Group 5) and RAI+ ADMSC after 48 h (Group 6). We used light microscopy (LM), transmission electron microscopy (TEM), and salivary gland scintigraphy (SGS), and analyzed data statistically. Results. We observed the homing of ADMSC in salivary glands at 1st month on LM. RAI exposure affected necrosis, periductal fibrosis, periductal sclerosis, vascular sclerosis and the total sum score were in a statistically significant manner (P 0.05). We observed a significant deterioration in gland function in group 1, whereas, mild to moderate deteriorations were seen in protective treatment groups. Conclusions. Our results indicated that ADMSC might play a promising role as a protective/regenerative agent against RAI-induced salivary gland dysfunction