A CLINICAL STUDY OF CHARAKOKTA SAUVARCHALADI CHURNA IN SHWAS (ASTHMA)

Objectives: This study was conducted to evaluate the comparative effectiveness of Charakokta sauvarchaladi churna and Theo-asthalin in Shwas”, it aimed at evaluating the efficacy of Sauvarchaladi Churna in Shwas. Materials and Methods: A study was conducted and 60 patients were randomly selected of Shwas, attending OPD or IPD department of Kayachikitsa OPD was included in study and divided into 2 groups. In Group A 30 patients were selected and trial drug was advocated in a dose of 3gm twice a day with Koshna Jal as Anupana. In Group B 30 patients were selected, Tab Theo-Asthalin was given twice a day. Treatment was given for 30 days with the result assessment recorded at every 5 days. Subjective and objective parameters were analyzed before and after the treatment. In subjective parameters Pinasa, Kasa veg, Kapha Sthivan, Shwas Veg gati, Asino Labhate Saukhyam, Ghurghurakam, while ESR, Chest Expansion, Breath holding time and Peak Expiratory Flow Rate (PEFR) are considered as objective parameters. Results: Effect of the Sauverchaladi churn (Group A) and Tab. Theo-Asthalin (Group B) on symptoms observed in Shwas is statistically proved to be significant. But on comparison between two groups, group A is more effective in reducing the symptoms Kasa veg, Kapha Sthivan, Shwas Veg gati, Asino Labhate Saukhyam. In reducing the symptoms Pinasa and Ghurghurakam there is no significant difference between two groups i.e. both groups are equally effective. It was observed that total percentage of relief in symptoms in Group A is 75.24%, whereas in Group B it was found 63.86%. It shows that Group A therapy of Saauvarchaladi churna is more effective in relieving symptoms of Shwas. Conclusion: Comparison between two groups was statistically evaluated by chi- square test. The Chi-square value 7.929 at 2 degrees of freedom, P<0.001 which is statistically highly significant which suggest that Group A was more effective than Group B

FORMULATION AND EVALUATION OF IBUPROFEN GASTRO-RETENTIVE FLOATING TABLETS

Objective: The objective of the present study was to formulate the gastro-retentive floating tablets containing Ibuprofen, which would remain in stomach and/or upper part of GIT for prolonged period of time. Floating systems have low bulk density so that they can float on the gastric juice in the stomach. Ibuprofen is an anti inflammatory drug.   Methods: On trial and error basis formulation design was done. Four different batches of floating tablets of Ibuprofen were prepared using HPMC, Xanthan gum, and gas generating agent sodium bicarbonate and citric acid. The tablets were characterized for the pre and post compression parameters such as friability, hardness, thickness, drug content, weight variation, in-vitro buoyancy studies and 13 hrs in-vitro drug release studies and the results were within the limits. Results: There was no interaction found in between drug and other ingredients. Maximum release was shown by formulation of batch F4 (47.38%), and minimum by the formulations of batch F2 (34.46%) in the duration of 13 hrs. Conclusion: From the results obtained, it was concluded that the optimized formulation F4 desired drug release properties and floating behavior.      Peer Review History: Received 13 June 2018;   Revised 26 August; Accepted 3 September, Available online 15 September 2018 UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file:        Reviewer's Comments: Average Peer review marks at initial stage: 2/10 Average Peer review marks at publication stage: 7/10 Reviewer(s) detail: Dr. Heba M. Abd El-Azim, Damanhour University, Egypt, [email protected] Dr. Sally A. El-Zahaby, Pharos University in Alexandria, Egypt, [email protected] Similar Articles: DEVELOPMENT AND EVALUATION OF RITONAVIR HOLLOW MICROBALLOONS FOR FLOATING DRUG DELIVERY DEVELOPMENT AND EVALUATION OF IN SITU GELLING GASTRORETENTIVE FORMULATIONS OF MELOXICAM This article has been cited by: Sachin Sarashetti, Vikas Jain, Gowda D V, Pooja Mallya, & Satish Babu. (2020). Recent developments in orally disintegrating mini tablets. International Journal of Research in Pharmaceutical Sciences, 11(3), 3606-3612. Pubme

FABRICATION AND EVALUATION OF HERBAL OINTMENT FORMULATIONS OF MORINGA OLEIFERA FOR TOPICAL DELIVERY

Objective: Traditional medicine is an important source of potentially useful new compounds for the development of chemotherapeutic agents. Moringa oleifera Lam. is a multipurpose and exceptionally nutritious vegetable tree with a variety of potential uses. It is distributed in many countries of the tropics and subtropics. Ointments are semisolid systems which behave as viscoelastic materials when shear stress is applied. They contain medicaments and are intended to be applied externally to the body or to the mucous membrane. Methods: In present study the Morenga oleifera leaves extract was used to formulate four different ointment formulations with different bases like cetostearyl alcohol, hard paraffin, and liquid paraffin. Formulations were evaluated for different parameters such as general appearance, spreadability, pH, extrudability, centrifugation,   irritancy, loss on drying, stability study etc. Results: All formulations were found to be free of grittiness, homogeneous, without phase separation with green colour with a smooth homogeneous texture and glossy appearance. Viscosity of the ointment formulations was in the range of 32.21±0.51 to 35.3±0.4. Formulations were found to be stable at different temperature. Conclusion: On the basis of results it can be concluded that ointment preparations with extract of Morenga oleifera leaves indicated the suitability of method for the production of ointments. Peer Review History: Received 13 June 2018;   Revised 27 August; Accepted 1 September, Available online 15 September 2018 UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file:        Reviewer's Comments: Average Peer review marks at initial stage: 3.5/10 Average Peer review marks at publication stage: 7.5/10 Reviewer(s) detail: Dr. Jennifer Audu-Peter, University of Jos, Nigeria, [email protected] Dr. Emmanuel O. Olorunsola, Department of Pharmaceutics & Pharmaceutical Technology, University of Uyo, Nigeria, [email protected] Similar Articles: A RECENT OVERVIEW OF LOCALLY ADMINISTERED TOPICAL OTIC DOSAGE FORM