Level of Psychological Adjustment and Intolerance Uncertainty among Heart Surgery Patients

To perceive the association among psychological adjustment and intolerance uncertainty among heart surgery patients, the present research was conducted. On the basis of purposive sampling method, a sample of 100 was chosen. These patients of BVH, completed the questionnaire forms. From BVH, the sample was purposively selected. By enumerating the percentages, the gathered data was examined and the interpretation was obtained on the base of findings of each type of questionnaire. For examining the data, descriptive statistics, correlation; SPSS was used. On the basis of findings and conclusion, the endorsement was drawn. Among researchers, psychological adjustment is increasingly getting popular as for analyzing behavior, conflicts, obstacles and misrepresenting varied social involvements that pupil go through as executive at workplaces and intolerance uncertainty investigation cogitative, profundity of future uncertainty as intimidating about their disease. Furthermore, there was a pessimistic association among psychological adjustment and intolerance uncertainty

ABO Blood Groups And Their Link With The Risk of Pre-Eclampsia

ABO blood group antigens have been identified as pathological agent in different disease conditions. For some time, the association of blood group with pregnancy associated conditions like pre-eclampsia is extensively under debate. Preeclampsia is a distressing condition of pregnancy which commonly causes maternal and fetal mortality around the globe. Multiple risk factors are found to be associated with preeclamptic occurrence. In this study our aim was to delineate a specific blood group which could be implicated as a risk factor for pre-eclampsia. Methods: This retrospective study was conducted in a tertiary care hospital of Karachi and retrieved obstetric data including blood group was from medical record files of 368 patients. Obtained data was analyzed by IBM SPSS version 21. Results: The prevalence of B group was recorded to be 41.3% as compared to O (26.1%), A (22.8%) and AB (9.8%). So, it can be concluded that women having blood group B are more prone to develop pre-eclampsia. Conclusion: Blood grouping of pregnant women in early weeks of pregnancy could assist in prediction or better management of pre-eclampsia

An in-vitro evaluation of skin protection factor of non-polar date seed extract from three different date varieties Ajwa, Aseel and Khapra by UV spectrophotometry

Objective: Skin is the primary layer of human body which act as protective barrier against exogenous chemicals, UV radiations as well as microorganisms. Maintaining the skin morphology under regular environmental stresses and controlling age related skin changes is one of the biggest challenges for modern science, pharmaceutical and cosmetics industry. These environmental stresses, such as excessive exposure to UV radiations, can even lead to the devastating skin disorders such as skin cancer. Dates seed has capability to protect skin against the damages caused by solar radiations, which mostly appear in the forms of wrinkles and some other skin related issues. Methods: Therefore, current research is focused on to analyze sun protection factor (SPF) of two non-polar fractions obtained from crushed seeds of three different varieties of i.e., Ajwa, Aseel and Khapra. Results: Results indicate that the highest value of SPF was found in AEA i.e., 15.061 at 200ppm while no difference was observed in the SPF values of KPPE. Conclusion: Hence, it could be concluded that the ethyl acetate fraction of all date seed varieties could be potential Ajwa, Aseel and Khapra could be a promising source of cosmetic and pharmaceutical preparations due to the potential SPF value except petroleum ether of Khapra extract

TRANSFORMATION OF INDIAN NATIONALISM AND ‘OTHERIZATION’ OF MUSLIMS IN INDIA

India has altered its military stratagem under the Modi government from nuclear deterrence to offensive defence. The constant use of offensive defence in the milieu of deliberate political aggression against Pakistan and victimization of the Muslim community in India is making Indian military doctrine a hostage of hyper-nationalistic politics of Hindutva. Since its rise to power, the BJP government has conflated anti-Muslim and anti-Pakistan approaches. Pakistan remains a crucial factor in its domestic, diplomatic, and foreign policy rhetoric. The internal discord and surge of violence against the Muslim population, as evident by 2020-riots in north-eastern New Delhi, are indicative of vigorous reforming of the national identity of India dominated by Hindutva ideology. Therefore, this paper addresses Hindu nationalism, which arose as a political ideology and caused an insecure environment for Indian Muslims while becoming precarious for Pakistan. It infers that Hindu nationalism, along with its assimilation approach towards minorities, is gradually asserting exclusionary conception of a state where cultural and political centrality of Hindutva has become a core theme.   Bibliography Entry Shahzad, Aisha, Sadia Mahmood Falki, and Asma Sana Bilal. 2021. "Transformation of Indian Nationalism and ‘Otherization’ of Muslims in India." Margalla Papers 25 (1): 48-58

Evaluation of soluble TNF-like weak inducer of apoptosis (sTWEAK) levels to predict preeclampsia in early weeks of pregnancy

Introduction: Soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) is linked to endothelial dysfunction; a key factor in pre-eclamptic pathogenesis. This study aimed to compare sTWEAK levels during pregnancy to assess for its prognostic ability.Materials and Methods: Sixty three high risk pregnant women were followed up from 12 weeks of gestation till term. Serum levels of sTWEAK and platelet derived growth factor (PlGF), blood pressure, serum glucose, uric acid, urea/creatinine and liver function tests were measured. Subjects were stratified according to the ACOG criteria as women who developed PE, or PIH or remained normotensive at term. A negative control group of normotensive healthy pregnant women (n = 17) was also recruited for comparison.Results: Baseline sTWEAK levels were lower (4.03 ± 0.37 ng/dl) in HR cohort that developed PE and further reduced at term (1.93 ± 0.23 ng/dl) as compared to HR subjects who remained normotensive and negative control group (30.53 ± 0.79 ng/dl; p \u3c 0.01). Likewise PlGF levels were significantly lower (74.22 ± 10.11 pg/ml) in HR cohort that developed PE (p = 0.013). At term 39.68% (n = 22) HR subjects with low sTWEAK developed PIH and 34.92% (n = 24) developed PE. In terms of high risk characteristics observed in the HR group; 73% of the subjects were multiparous, whereas 26.98% reported to have developed PE in previous pregnancies.Conclusion: sTWEAK levels at early pregnancy weeks were found to be low in high risk females who developed PE at follow up versus normotensive pregnant women. Baseline TWEAK might serve as an independent variable for prediction of pre-eclampsia; however longitudinal studies with larger sample size are required to ascertain the causal relation

Evaluation of kidney injury molecule-1 as a disease progression biomarker in diabetic nephropathy

Background & Objective: Kidney Injury Molecule-1 (KIM-1) is a peptide whose release into circulation is specific to tubular injury. This study aimed to estimate levels of kidney injury molecule-1 in diabetic patients with and without kidney disease. And evaluate the role of KIM-1 as an early screening marker of progressive kidney injury.Methods: This follow-up study included n=85 subjects from the diabetic clinic of Jinnah Post Graduate Medical Center (JPMC) in collaboration with Aga Khan University from November 2016 till September 2017. They were divided as: i) Group A1 (n=30) participants with diabetes for \u3c5 years without microalbuminuria ii) Group A2 (n= 30) subjects with diabetes for 6-10 years with microalbuminuria; iii) Group B (n=25) subjects as healthy control group. All study participants were followed for 6 months and their blood glucose, urea, creatinine, electrolytes, albuminuria and serum KIM-1 were assayed.Results: High KIM-1 at baseline was present in group A2 patients as compared to controls and group A1 (p\u3c0.001). Higher levels were seen after six months in group A1 along with the presence of micro albuminuria (p\u3c0.001) suggesting kidney damage. Moderate positive association were seen for KIM1 with creatinine levels (r=0.530; p\u3c0.001), and HbA1c (r=0.576; p\u3c0.001) in all patients. While a strong positive association was seen for blood urea nitrogen as a marker for kidney function both at baseline (r= 0.728; p=0.000) and follow up (r=0.747; p=0.001). Multiple logistic regression controlling for age showed that KIM1 was independently associated with BUN (r=0.727; p\u3c0.001), creatinine (r=0.510; p\u3c0.001) and HbA1c (r=0.401; p=0.008) in all groups.Conclusion: Rising KIM-1 levels with progressive kidney damage with or without derangement of kidney function is reported in this study. This finding may pave a way towards identifying KIM1 as a prognostic marker for kidney injury

Parkinson disease: identifying different players sharing a common principle

Parkinson disease is a multifactorial molecular disorder. Miscellaneous regulators have been characterized to date and their implication in disease progression is well documented. Compromised neuromuscular activity is a serious threat posed by malfunctioning of various regulators. The integrity and maintenance of neural architecture underpins neural activities. Despite the fact that various breakthroughs have been made, yet many proteins are unidentified while some unaddressed. Furthermore, miRNA pathway impairment results in subversion of core biological system and draws attention towards novel miRNA-based therapeutic strategies. Thus proteins and mitrons work in collaboration with various cellular organelles to ensure normal dynamics of neural circuitry. In this review we will emphasize the derailed activities of proteins at molecular level that might help in getting a step closer to personalized medicine

Frequency of depression and anxiety among patients with chronic spontaneous urticaria visiting a tertiary care hospital in Karachi, Pakistan

Objective: To determine the frequency of anxiety and depression among chronic spontaneous urticarial patients presenting at a tertiary care hospital.Methods: The prospective, cross-sectional study was conducted at the Aga Khan University Hospital, Karachi, from February to August 2015, and comprised patients diagnosed with chronic spontaneous urticaria at the dermatology clinic. All the participants were assessed for anxiety and depression using Aga Khan University-Anxiety Depression Scale. Data was collected in face-to-face interview using a structured questionnaire. The association of the condition with different characteristics were calculated after stratification for age, gender, occupation and monthly income. SPSS 19 was used for data analysis..Results: Of the 146 study participants, 84(57.5%) were males and 62(42.5%) were females. The overall mean age was 39±15.6 years. Of the total, 39(26.7%) had depression and anxiety. Depression and anxiety were more frequent among patients with a positive family history of mental disorders (p=0.02).Conclusion: Anxiety and depression were found to be considerably common among chronic spontaneous urticaria patients, with patients having a positive family history for mental illnesses particularly vulnerable

Epidermal growth factor receptor rs17337023 polymorphism in hypertensive gestational diabetic women: A pilot study

Background: Women with gestational diabetes mellitus have an increased risk of developing gestational hypertension, which can increase fetal and neonatal morbidity and mortality. In the past decade, single nucleotide polymorphisms in several genes have been identified as risk factors for development of gestational hypertension. The epidermal growth factor receptor activates tyrosine kinase mediated blood vessels contractility; and inflammatory cascades. Abnormalities in these mechanism are known to contribute towards hypertension. It is thus plausible that polymorphisms in the epidermal growth factor receptor gene would be associated with the development of hypertension in women with gestational diabetes.Aim: To determine whether the epidermal growth factor receptor rs17337023 SNP is associated with the occurrence of hypertension in gestational diabetic women.Methods: This pilot case-control study was conducted at two tertiary care hospitals in Karachi, from January 2017-August 2018. Two hundred and two women at 28 week of gestation with gestational diabetes were recruited and classified into normotensive (n = 80) and hypertensive (n = 122) groups. Their blood samples were genotyped for epidermal growth factor receptor polymorphism rs17337023 using tetra-ARMS polymerase chain reaction. Descriptive analysis was applied on baseline data. Polymorphism data was analyzed for genotype and allele frequency determination using chi-squared statistics. In all cases, a P value of \u3c 0.05 was considered significant.Results: Subjects were age-matched and thus no difference was observed in relation to age of the study subjects (P \u3e0.05). Body fat percentage was significantly higher in hypertensive females as compared to normotensive subjects (35.138 ± 4.29 Case vs 25.01 ± 8.28 Control; P \u3c 0.05). Similarly, systolic and diastolic blood pressures among groups were significantly higher in hypertensive group than the normotensive group (P \u3c 0.05). Overall epidermal growth factor receptor rs17337023 polymorphism genotype frequency was similar in both groups, with the heterozygous AT genotype (56 in Case vs 48 in Control; P = 0. 079) showing predominance in both groups. Furthermore, the odds ratio for A allele was 1.282 (P = 0.219) and for T allele was 0.780 (P = 0.221) in this study.Conclusion: This pilot study indicates that polymorphisms in rs17337023 may not be involved in the pathophysiology of gestational hypertension in gestational diabetes via inflammatory cascade mechanism. Further large-scale studies should explore polymorphism in epidermal growth factor receptor and other genes in this regard

The Eastern and Western amalgamation: a dilemma for Pakistani artists

This research explores the combination of Eastern and Western amalgamation in the artwork of Farhat Ali painter. This East and West cultural diffusion discourses inquiries about cultural identity and its conceivable effect. During academics, curriculum studying, and practising Western art and in the paintings, the painter has to produce the-eastern approach. It was unsuccessful as it made the East and West divisions unspecified because the artist had to do such work, which belonged to the culture. The basic structures within the institutions are copied from the West and mainly affect the local art sector and most of the communication being done, which is a clear effect of post-colonialism. It is apparent from Farhat Ali’s work and his practice entirely that he has shrewdly noticed this conflict. Farhat Ali’s choreographed gestures and their placement make for highly dramatized illustrations. It might incorporate calligraphy, miniature painting techniques, or traditional patterns into a modernist painting or use contemporary materials and colours to create classic images. Ultimately, the researcher will prove the East and West combination is a trauma for Pakistani painters. This study also accentuates sociolect-psychoanalytical cultural conflicts and how to affect the feeling and behaviour of characters